Abstract：
:The pattern of hormone secretion by human pituitary tumours in cell or explant culture has been shown to be of value in establishing the nature of the tissue. There was complete agreement between the diagnosis reached by conventional immunocytochemical techniques and by examining the secretion of hormones in culture. Culture techniques, however, have some advantages over immunocytochemical analysis. In particular, immunocytochemical techniques can only be used to examine a small, possibly unrepresentative, portion of the pituitary tissue, whereas the in vitro culture systems make use of the whole tissue. In addition, in vitro culture is simpler to employ and can be carried out relatively rapidly. Cell and explant culture was therefore used to examine the nature of human pituitary tumours. To determine the incidence of mixed GH-PRL secreting pituitary tumours in acromegaly, the pattern of hormone secretion in vitro by 98 somatotrophic tumours was examined. Thirty-seven per cent were found to be pure somatotrophic tumours and 59.2% secreted both GH and PRL, but no other hormone, indicating that these tumours were of mixed nature. This latter group could be divided into those removed from patients with hyperprolactinaemia (35.7% of all tumours) and those from patients with normal pre-operative serum PRL levels (23.5%). A further small group (3.1%) of tumours secreted only GH in culture, despite elevated pre-operative serum PRL levels, indicating that the hyperprolactinaemia in these patients was due to pituitary stalk compression by the somatotrophic tumour, thereby preventing prolactin release inhibiting factor reaching the lactotrophs and allowing uncontrolled PRL secretion.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Neurosurg Revjournal_title
Neurosurgical reviewauthors
Adams EF,Mashiter Kdoi
10.1007/BF01815438subject
Has Abstractpub_date
1985-01-01 00:00:00pages
135-40issue
3-4eissn
0344-5607issn
1437-2320journal_volume
8pub_type
杂志文章abstract：:It was suggested that D, L-Methadone might improve the clinical course of glioma patients. Owing to massive press coverage, patients demand the prescription of D, L-Methadone, but regarding its adjunctive use in glioma therapy there is no standard medication plan. Furthermore, it is not known which side effects the ad...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-020-01250-1
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abstract：:We present 78 patients with spinal cord injuries. Operation is not indicated in cord contusion, extended bleeding into the spinal canal or severe fracture dislocation. However, it would seem advisable to operate on patients with vertebral fractures, particularly at the lower thoracic and lumbar levels, if intraspinal ...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/BF01790702
更新日期：1989-01-01 00:00:00
abstract：:Forty-four adult acromegalic patients carrying growth hormone-producing pituitary macroadenomas were investigated with neuroradiological and endocrinological techniques. Plasma growth hormone and somatomedin-C levels were repeatedly measured before surgical removal of tumors and during the follow-up period. Twenty-fiv...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/BF01105562
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abstract：:Amyotrophic lateral sclerosis (ALS) is a progressive, degenerative disease of the nervous system. It affects adults in all age groups and leads to death few years after the diagnosis. The etiology is unknown, and there no convincing medical or surgical therapy Some diseases can mimic ALS. If diagnosed early these may ...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/BF01105785
更新日期：1998-01-01 00:00:00
abstract：:200 stereotactic biopsies were evaluated. The validity of the intraoperative histopathological results were compared with the final diagnosis using conventional embedding and staining techniques. Further comparison between the histology of the biopsy and the post mortem or open operative findings were possible in 41 c...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/BF00309989
更新日期：1994-01-01 00:00:00
abstract：:Clinical practice guidelines (CPGs) play an important role in healthcare. The guideline development process should be precise and rigorous to ensure that the results are reproducible and not vague. To determine the quality of guidelines, the Appraisal of Guidelines and Research and Evaluation (AGREE) instrument was de...
journal_title：Neurosurgical review
pub_type： 杂志文章,评审
doi：10.1007/s10143-014-0569-z
更新日期：2015-01-01 00:00:00
abstract：:Surgery is the only therapeutic option for cerebral cavernous malformations (CCM) and is proposed, whenever possible, after haemorrhagic events, neurological symptoms, or epilepsy, radiosurgery being a controversial alternative in some cases. However, there is no treatment for non-accessible lesions, such as brainstem...
journal_title：Neurosurgical review
pub_type： 杂志文章,评审
doi：10.1007/s10143-018-01074-0
更新日期：2019-06-01 00:00:00
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journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-017-0873-5
更新日期：2018-04-01 00:00:00
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journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-016-0747-2
更新日期：2017-01-01 00:00:00
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journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-017-0877-1
更新日期：2018-04-01 00:00:00
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journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/BF00345936
更新日期：1992-01-01 00:00:00
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journal_title：Neurosurgical review
pub_type： 杂志文章,评审
doi：10.1007/s10143-004-0366-1
更新日期：2005-04-01 00:00:00
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journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-018-1011-8
更新日期：2019-12-01 00:00:00
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journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-010-0251-z
更新日期：2010-07-01 00:00:00
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journal_title：Neurosurgical review
pub_type： 杂志文章,评审
doi：10.1007/s10143-020-01292-5
更新日期：2020-04-21 00:00:00
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journal_title：Neurosurgical review
pub_type： 杂志文章,评审
doi：10.1007/s10143-010-0294-1
更新日期：2011-01-01 00:00:00
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journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-017-0842-z
更新日期：2018-01-01 00:00:00
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journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-003-0315-4
更新日期：2004-04-01 00:00:00
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journal_title：Neurosurgical review
pub_type： 杂志文章
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journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/BF01787121
更新日期：1989-01-01 00:00:00
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journal_title：Neurosurgical review
pub_type： 杂志文章,评审
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journal_title：Neurosurgical review
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更新日期：1987-01-01 00:00:00
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journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/BF00416478
更新日期：1995-01-01 00:00:00
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journal_title：Neurosurgical review
pub_type： 杂志文章
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更新日期：2007-04-01 00:00:00
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journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/BF01790694
更新日期：1989-01-01 00:00:00
abstract：:Preoperative prediction of molecular information of lower-grade gliomas (LrGGs) helps to determine the overall treatment strategy as well as the initial surgical strategy. This study aimed to detect magnetic resonance imaging (MRI) texture parameters to predict the molecular signature of LrGGs using a commercially ava...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-019-01157-6
更新日期：2020-08-01 00:00:00
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journal_title：Neurosurgical review
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更新日期：2020-02-01 00:00:00
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journal_title：Neurosurgical review
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更新日期：2019-12-01 00:00:00
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journal_title：Neurosurgical review
pub_type： 杂志文章,meta分析,评审
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更新日期：2009-01-01 00:00:00
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journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-003-0257-x
更新日期：2003-07-01 00:00:00
