Abstract:
:This study sought to describe and evaluate any relationship between D-dimer values and progressive hemorrhagic injury (PHI) after traumatic brain injury (TBI). In patients with TBI, plasma D-dimer was measured while a computed tomography (CT) scan was conducted as soon as the patient was admitted to the emergency department. A series of other clinical and laboratory parameters were also measured and recorded. A logistic multiple regression analysis was used to identify risk factors for PHI. A cohort of 194 patients with TBI was evaluated in this clinical study. Eighty-one (41.8%) patients suffered PHI as determined by a second CT scan. The plasma D-dimer level was higher in patients who demonstrated PHI compared with those who did not (P < 0.001. Using a receiver-operator characteristic curve to predict the possibility by measuring the D-dimer level, a value of 5.00 mg/L was considered the cutoff point, with a sensitivity of 72.8% and a specificity of 78.8%. Eight-four patients had D-dimer levels higher than the cut point value (5.0 mg/L); PHI was seen in 71.4% of these patients and in 19.1% of the other patients (P < 0.01). Factors with P < 0.2 on bivariate analysis were included in a stepwise logistic regression analysis to identify independent risk factors for TBI coagulopathy. Logistic regression analysis showed that the D-dimer value was a predictor of PHI, and the odds ratio (OR) was 1.341 with per milligram per liter (P = 0.020). The stepwise logistic regression also identified that time from injury to the first CT shorter than 2 h (OR = 2.118, P = 0.047), PLT counts lesser than 100 x 109/L (OR = 7.853, P = 0.018), and Fg lower than 2.0 g/L (OR = 3.001, P = 0.012) were risk factors for the development of PHI. When D-dimer values were dichotomized at 5 mg/L, time from injury to the first CT scan was no longer a risk factor statistically while the OR value of D-dimer to the occurrence of PHI elevated to 11.850(P < 0.001). The level of plasma D-dimer after TBI can be a useful prognostic factor for PHI and should be considered in the clinical management of patients in combination with neuroimaging and other data.
journal_name
Neurosurg Revjournal_title
Neurosurgical reviewauthors
Tian HL,Chen H,Wu BS,Cao HL,Xu T,Hu J,Wang G,Gao WW,Lin ZK,Chen SWdoi
10.1007/s10143-010-0251-zsubject
Has Abstractpub_date
2010-07-01 00:00:00pages
359-65; discussion 365-6issue
3eissn
0344-5607issn
1437-2320journal_volume
33pub_type
杂志文章abstract::A primary xanthomatous tumor is very rare in the central nervous system (CNS). Here we report the case of a fibroxanthoma arising from the dura mater of the cerebrum that demonstrated no systemic disease or metabolic abnormalities. A 19-month-old, otherwise healthy boy was found to have an enlarged head. Magnetic reso...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s101430050019
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abstract::Cerebral infarction (CI) associated with clipping of unruptured intracranial aneurysms (UIAs) has not been completely studied. The role of individual and operative characteristics is not known, and the risk of silent CI has not been well described. To determine the incidence, risk factors, and clinical outcome of post...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-017-0913-1
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journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF00417662
更新日期:1995-01-01 00:00:00
abstract::Teflon is utilized in neurosurgery as well as in plastic, vascular and heart surgery. Although the effect of Teflon on different types of cells and tissues has been previously studied, we are not aware of any study in which the effect of Teflon was tested on cells of the central nervous system. We have therefore exami...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF00346368
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abstract::Intraoperative magnetic resonance imaging (iopMRI) actually has an important role in the surgery of brain tumors, especially gliomas and pituitary adenomas. The aim of our work was to describe the advantages and drawbacks of this tool for the surgical treatment of cervical intramedullary gliomas. We describe two expli...
journal_title:Neurosurgical review
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journal_title:Neurosurgical review
pub_type: 杂志文章
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journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF01743105
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pub_type: 临床试验,杂志文章
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journal_title:Neurosurgical review
pub_type: 杂志文章
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更新日期:2017-10-01 00:00:00
abstract::The unruptured intracranial aneurysm treatment score (UIATS) was published in April 2015 as a multidisciplinary consensus regarding treatment of unruptured intracranial aneurysms (UIA). As a tertiary center with focus on vascular neurosurgery, we aimed to investigate whether our treatment decision-making in patients w...
journal_title:Neurosurgical review
pub_type: 杂志文章
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journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF01105775
更新日期:1998-01-01 00:00:00
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journal_title:Neurosurgical review
pub_type: 杂志文章
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journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF01781950
更新日期:1987-01-01 00:00:00
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journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-003-0257-x
更新日期:2003-07-01 00:00:00
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journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-019-01226-w
更新日期:2019-12-24 00:00:00
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journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-020-01320-4
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journal_title:Neurosurgical review
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Neurosurgical review
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pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-012-0408-z
更新日期:2013-01-01 00:00:00
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journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF01138194
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doi:10.1007/s10143-007-0084-6
更新日期:2007-07-01 00:00:00
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pub_type: 杂志文章,评审
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