Abstract:
:Cytoplasts derived from senescent and quiescent human diploid cells inhibit DNA synthesis initiation when fused with cells capable of proliferation. When the cytoplasts were subjected to a variety of conditions (trypsin and cycloheximide treatment and growth on fibronectin), this inhibitory activity was lost, suggesting that the inhibitors involved were proteins associated with the surface membranes of the cells. We have studied the quiescent cell inhibitor in greater detail and determined that surface membrane-enriched preparations isolated from quiescent cells and proteins extracted from these membrane preparations have DNA synthesis-inhibitory activity.
journal_name
Exp Cell Resjournal_title
Experimental cell researchauthors
Pereira-Smith OM,Fisher SF,Smith JRdoi
10.1016/0014-4827(85)90177-6subject
Has Abstractpub_date
1985-10-01 00:00:00pages
297-306issue
2eissn
0014-4827issn
1090-2422journal_volume
160pub_type
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