Acetohydroxy acid synthase I is required for isoleucine and valine biosynthesis by Salmonella typhimurium LT2 during growth on acetate or long-chain fatty acids.

Abstract:

:Salmonella typhimurium LT2 normally expresses two acetohydroxy acid synthases (AHAS I and AHAS II). The function of AHAS I in this organism was unclear, since AHAS I-deficient (ilvBN) mutants of LT2 grew well on glucose or succinate minimal media, whereas AHAS II-deficient (ilvGM) mutants requried isoleucine for normal growth on glucose minimal media. We report that AHAS I-deficient mutants of S. typhimurium required isoleucine and valine for growth on acetate or oleate minimal media, whereas AHAS II-deficient mutants were able to grow on these media without isoleucine supplementation.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Dailey FE,Cronan JE Jr,Maloy SR

doi

10.1128/jb.169.2.917-919.1987

subject

Has Abstract

pub_date

1987-02-01 00:00:00

pages

917-9

issue

2

eissn

0021-9193

issn

1098-5530

journal_volume

169

pub_type

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