Regulation of arginase activity by intermediates of the arginine biosynthetic pathway in Neurospora crassa.

Abstract:

:It has been found that, in Neurospora crassa, arginine synthesized from exogenous citrulline was not as effectively hydrolyzed as exogenous arginine. This was explained by the observed inhibition of arginase in vitro and in vivo by citrulline. The high arginine pool formed from exogenous citrulline feedback inhibits the arginine pathway. These two factors allow exogenous citrulline to be used adventitiously and efficiently as an arginine source. Finally, it was found that ornithine was a strong inhibitor of arginase. This suggests that the characteristically high ornithine pool of minimal cultures of Neurospora may act to control a potentially wasteful catabolism of endogenous arginine by arginase.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Mora J,Salceda R,Sanchez S

doi

10.1128/JB.110.3.870-877.1972

subject

Has Abstract

pub_date

1972-06-01 00:00:00

pages

870-7

issue

3

eissn

0021-9193

issn

1098-5530

journal_volume

110

pub_type

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