Abstract:
:Converging evidence from electrophysiological recording and lesion studies suggests an essential role for the cerebellum in classical conditioning of the nictitating membrane response in the rabbit. The present study begins to delineate within this structure neurotransmitter systems that appear critical for the expression of this form of simple associative learning. Experiments reported here demonstrate that microinfusion of gamma-aminobutyric acid (GABA) antagonists (either bicuculline methiodide or picrotoxin) into specific areas of the medial dentate/lateral interpositus nuclei or into the cerebellar cortex of lobule HVI can selectively and reversibly abolish conditioned responding, while leaving the unconditioned reflex response intact. The results are consistent with the suggestion that GABAergic synapses play an essential role in the circuitry that mediates the conditioned response.
journal_name
Proc Natl Acad Sci U S Aauthors
Mamounas LA,Thompson RF,Madden J 4thdoi
10.1073/pnas.84.7.2101subject
Has Abstractpub_date
1987-04-01 00:00:00pages
2101-5issue
7eissn
0027-8424issn
1091-6490journal_volume
84pub_type
杂志文章abstract::A form of two-dimensional (2D) vibrational spectroscopy, which uses two ultrafast IR laser pulses, is used to examine the structure of a cyclic penta-peptide in solution. Spectrally resolved cross peaks occur in the off-diagonal region of the 2D IR spectrum of the amide I region, analogous to those in 2D NMR spectrosc...
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更新日期:2016-01-05 00:00:00