Interactions between internal forces, body stiffness, and fluid environment in a neuromechanical model of lamprey swimming.

abstract：:O(6)-methylguanine (O(6)meG) and related modifications of guanine in double-stranded DNA are functionally severe lesions that can be produced by many alkylating agents, including N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), a potent carcinogen. O(6)meG is repaired through its demethylation by the O(6)-alkylguanine-DNA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hwang CS,Shemorry A,Varshavsky A

更新日期：2009-02-17 00:00:00

abstract：:Switching from repressed to active status in chromatin regulation is part of the critical responses that plants deploy to survive in an ever-changing environment. We previously reported that HOS15, a WD40-repeat protein, is involved in histone deacetylation and cold tolerance in Arabidopsis However, it remained unknow...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park J,Lim CJ,Shen M,Park HJ,Cha JY,Iniesto E,Rubio V,Mengiste T,Zhu JK,Bressan RA,Lee SY,Lee BH,Jin JB,Pardo JM,Kim WY,Yun DJ

更新日期：2018-06-05 00:00:00

abstract：:Fast-atom bombardment mass spectrometry was used to follow the time course of disulfide bond formation during in vitro refolding of recombinant human macrophage-colony-stimulating factor. The content of iodoacetamide-alkylated half-cystines in proteolytic peptides of trapped refolding intermediates collected at 0, 6, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Glocker MO,Arbogast B,Milley R,Cowgill C,Deinzer ML

更新日期：1994-06-21 00:00:00

abstract：:Historically, rate constants were determined in vitro and it was unknown whether they were valid for in vivo biological processes. Here, we bridge this gap by measuring binding dynamics between a pair of proteins in living HeLa cells. Binding of a β-lactamase to its protein inhibitor was initiated by microinjection an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Phillip Y,Kiss V,Schreiber G

更新日期：2012-01-31 00:00:00

abstract：:Photochemical oxidation of aromatic hydrocarbons leads to tropospheric ozone and secondary organic aerosol (SOA) formation, with profound implications for air quality, human health, and climate. Toluene is the most abundant aromatic compound under urban environments, but its detailed chemical oxidation mechanism remai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ji Y,Zhao J,Terazono H,Misawa K,Levitt NP,Li Y,Lin Y,Peng J,Wang Y,Duan L,Pan B,Zhang F,Feng X,An T,Marrero-Ortiz W,Secrest J,Zhang AL,Shibuya K,Molina MJ,Zhang R

更新日期：2017-08-01 00:00:00

abstract：:Soluble, glutathione-stimulated delta 5-3-ketosteroid isomerase (EC 5.3.3.A) activity of human and rat liver resides in very basic proteins with molecular weights of about 45,000 which are present in high concentrations in these tissues. Physiochemical and immunological evidence is presented for the identity of the pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benson AM,Talalay P,Keen JH,Jakoby WB

更新日期：1977-01-01 00:00:00

abstract：:Amplitude-modulated phosphorescence/microwave double-resonance (AM-PMDR) spectra are reported for complexes of methylmercury(II) cation, designated CH3Hg(II), with tryptophan and glyceraldehyde-3-phosphate dehydrogenase (GPDHase; from rabbit muscle). Wavelength shifts are observed in the AM-PMDR spectra of CH3Hg(II)-t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davis JM,Maki AH

更新日期：1982-07-01 00:00:00

abstract：:We have investigated the regulation of the expression of two growth factors found in vascular smooth muscle, transforming growth factor alpha (TGF alpha) and basic fibroblast growth factor (bFGF). Cells cultured in medium containing 30 mM glucose exhibited a 2-fold increase in TGF alpha mRNA and a 3-fold increase in b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McClain DA,Paterson AJ,Roos MD,Wei X,Kudlow JE

更新日期：1992-09-01 00:00:00

abstract：:AvrXa7 is a member of the avrBs3 avirulence gene family, which encodes proteins targeted to plant cells by a type III secretion apparatus. AvrXa7, the product of avrXa7, is also a virulence factor in strain PXO86 of Xanthomonas oryzae pv. oryzae. Avirulence and virulence specificities are associated with the central r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang B,Zhu W,Johnson LB,White FF

更新日期：2000-08-15 00:00:00

abstract：:In the cell, proteins are synthesized from N to C terminus and begin to fold during translation. Cotranslational folding mechanisms are therefore linked to elongation rate, which varies as a function of synonymous codon usage. However, synonymous codon substitutions can affect many distinct cellular processes, which h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Walsh IM,Bowman MA,Soto Santarriaga IF,Rodriguez A,Clark PL

更新日期：2020-02-18 00:00:00

abstract：:Induction of longstanding immunologic tolerance is essential for survival of transplanted organs and tissues. Despite recent advances in immunosuppression protocols, allograft damage inflicted by antibody specific for donor organs continues to represent a major obstacle to graft survival. Here we report that activatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Choi JY,Eskandari SK,Cai S,Sulkaj I,Assaker JP,Allos H,AlHaddad J,Muhsin SA,Alhussain E,Mansouri A,Yeung MY,Seelen MAJ,Kim HJ,Cantor H,Azzi JR

更新日期：2020-03-17 00:00:00

abstract：:The eyes of some aquatic animals form images through reflective optics. Shrimp, lobsters, crayfish, and prawns possess reflecting superposition compound eyes, composed of thousands of square-faceted eye units (ommatidia). Mirrors in the upper part of the eye (the distal mirror) reflect light collected from many ommati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Palmer BA,Hirsch A,Brumfeld V,Aflalo ED,Pinkas I,Sagi A,Rosenne S,Oron D,Leiserowitz L,Kronik L,Weiner S,Addadi L

更新日期：2018-03-06 00:00:00

abstract：:Waves and patterns in living systems are often driven by biochemical reactions with enzymes as catalysts and regulators. We present a reaction-diffusion system catalyzed by the enzyme glucose oxidase that exhibits traveling wave patterns in a spatially extended medium. Fronts and pulses propagate as a result of the co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Míguez DG,Vanag VK,Epstein IR

更新日期：2007-04-24 00:00:00

abstract：:An improved mammalian two-hybrid system designed for interaction trap screening is described in this paper. CV-1/EBNA-1 monkey kidney epithelial cells expressing Epstein-Barr virus nuclear antigen 1 (EBNA-1) were stably transfected with a reporter plasmid for GAL4-dependent expression of the green fluorescent protein ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shioda T,Andriole S,Yahata T,Isselbacher KJ

更新日期：2000-05-09 00:00:00

abstract：:Results on the subcellular localization of the mineralocorticoid receptor (MR) have been controversial. To determine the subcellular distribution and trafficking of the MR in living cells after binding of agonists and antagonists, we expressed a MR-green fluorescent protein (GFP) chimera in mammalian cells lacking end...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fejes-Tóth G,Pearce D,Náray-Fejes-Tóth A

更新日期：1998-03-17 00:00:00

abstract：:The mature gag and pol proteins of human immunodeficiency virus (HIV) and all retroviruses derive from large gag and gag-pol polyprotein precursors by posttranslational cleavage. A highly specific, virally encoded protease is required for this essential proteolytic processing. In this study, the HIV protease gene prod...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Debouck C,Gorniak JG,Strickler JE,Meek TD,Metcalf BW,Rosenberg M

更新日期：1987-12-01 00:00:00

abstract：:We analyze the effects of an externally applied electric field on thermal fluctuations for a binary electrolyte fluid. We show that the fluctuating Poisson-Nernst-Planck (PNP) equations for charged multispecies diffusion coupled with the fluctuating fluid momentum equation result in enhanced charge transport via a mec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Péraud JP,Nonaka AJ,Bell JB,Donev A,Garcia AL

更新日期：2017-10-10 00:00:00

abstract：:Large-scale analysis of the GC-content distribution at the gene level reveals both common features and basic differences in genomes of different groups of species. Sharp changes in GC content are detected at the transcription boundaries for all species analyzed, including human, mouse, rat, chicken, fruit fly, and wor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang L,Kasif S,Cantor CR,Broude NE

更新日期：2004-11-30 00:00:00

abstract：:Forests and their soils contain the majority of the earth's terrestrial carbon stocks. Changes in patterns of tree growth can have a huge impact on atmospheric cycles, biogeochemical cycles, climate change, and biodiversity. Recent studies have shown increases in biomass across many forest types. This increase has bee...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McMahon SM,Parker GG,Miller DR

更新日期：2010-02-23 00:00:00

abstract：:Because synaptic vesicle exocytosis is a nano-mechanical process, it should be influenced by the mechanical properties of the cell membrane to which the vesicle fuses. By dissolving surfactants at various concentrations in the neuronal membrane, we have perturbed mechanical properties of the membrane and have found th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhu Y,Stevens CF

更新日期：2008-11-18 00:00:00

abstract：:This paper describes a variety of statistical methods for obtaining precise quantitative estimates of the similarities and differences in the structures of semantic domains in different languages. The methods include comparing mean correlations within and between groups, principal components analysis of interspeaker c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Romney AK,Moore CC,Batchelder WH,Hsia TL

更新日期：2000-01-04 00:00:00

abstract：:Relatively low concentrations of methylxanthines increase spontaneous twitching in cultured muscle fibers; they also cause a second activity, escalation, which is the initiation and undiminished propagation of visible waves. The effect on twitching is abolished by depolarizing concentrations of K(+) or by tetrodotoxin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coleman AW,Coleman JR,Griffin JD,Weltman JK,Chapman KM

更新日期：1972-03-01 00:00:00

abstract：:The identities between homogeneous expressions in rank 1 vectors and rank n - 1 covectors in a Grassmann-Cayley algebra of rank n, in which one set occurs multilinearly, are shown to represent a set of dimension-independent identities. The theorem yields an infinite set of nontrivial geometric identities from a given ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hawrylycz M

更新日期：1995-03-14 00:00:00

abstract：:Oncogenic mutations in the small GTPase KRAS are frequently found in human cancers, and, currently, there are no effective targeted therapies for these tumors. Using a combinatorial siRNA approach, we analyzed a panel of KRAS mutant colorectal and pancreatic cancer cell lines for their dependency on 28 gene nodes that...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee CS,Lee LC,Yuan TL,Chakka S,Fellmann C,Lowe SW,Caplen NJ,McCormick F,Luo J

更新日期：2019-03-05 00:00:00

abstract：:In addition to their roles in desensitization and signaling of seven-membrane-spanning receptors, beta-arrestins have been more recently implicated in regulating non-seven-membrane-spanning receptor pathways. By using a yeast two-hybrid screen, we identified the inhibitor of NF-kappaB, IkappaBalpha, as a binding partn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Witherow DS,Garrison TR,Miller WE,Lefkowitz RJ

更新日期：2004-06-08 00:00:00

abstract：:The cellulose synthesizing terminal complex consisting of subunits A, B, C, and D in Acetobacter xylinum spans the outer and inner cell membranes to synthesize and extrude glucan chains, which are assembled into subelementary fibrils and further into a ribbon. We determined the structures of subunit D (AxCeSD/AxBcsD) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hu SQ,Gao YG,Tajima K,Sunagawa N,Zhou Y,Kawano S,Fujiwara T,Yoda T,Shimura D,Satoh Y,Munekata M,Tanaka I,Yao M

更新日期：2010-10-19 00:00:00

abstract：:Hot methane spectra are important in environments ranging from flames to the atmospheres of cool stars and exoplanets. A new spectroscopic line list, 10to10, for (12)CH4 containing almost 10 billion transitions is presented. This comprehensive line list covers a broad spectroscopic range and is applicable for temperat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yurchenko SN,Tennyson J,Bailey J,Hollis MD,Tinetti G

更新日期：2014-07-01 00:00:00

abstract：:Cultures were prepared of embryonic cells from Drosophila melanogaster. Neurons and myocytes differentiated in vitro from their respective stem cells. Electron microscopy showed that neuromuscular junctions formed where axons contacted myocytes. Electrical stimuli were applied to axons and these caused contractions of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seecof RL,Teplitz RL,Gerson I,Ikeda K,Donady J

更新日期：1972-03-01 00:00:00

abstract：:The 1987 Montreal Protocol on Substances that Deplete the Ozone Layer is a landmark agreement that has successfully reduced the global production, consumption, and emissions of ozone-depleting substances (ODSs). ODSs are also greenhouse gases that contribute to the radiative forcing of climate change. Using historical...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Velders GJ,Andersen SO,Daniel JS,Fahey DW,McFarland M

更新日期：2007-03-20 00:00:00

abstract：:This article addresses the need for new data on indirect effects of natural and anthropogenic aerosol particles on atmospheric ice clouds. Simultaneous measurements of the concentration and composition of tropospheric aerosol particles capable of initiating ice in cold (cirrus) clouds are reported. Measurements suppor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： DeMott PJ,Cziczo DJ,Prenni AJ,Murphy DM,Kreidenweis SM,Thomson DS,Borys R,Rogers DC

更新日期：2003-12-09 00:00:00