Abstract:
:The results obtained during the investigation on the excretion of nine urinary antigens originating in the kidney and characterized by monoclonal antibodies and of the brush-border marker-enzyme alanine aminopeptidase in the urine of 12 volunteers before and during the administration of therapeutic doses of ciprofloxacin on seven consecutive days gave no indication that this drug exerts tubulo-toxic side effects. The mean excretion curves showed no significant increases during ciprofloxacin treatment for any of the nine kidney-derived antigens. The measured antigen-excretion courses correlated with the curve of the excretion of AAP, which was measured as a marker for the brush border of the proximal tubule, and also with the course of the fluid elimination. There was no indication of selective damage to the distal section of the tubular apparatus resulting from possible crystalluria. These results, as well as the fact that all the other laboratory parameters were within the normal range, indicate that the kidney function of the volunteers was normal during the observation period and that ciprofloxacin is tolerated by the kidney.
journal_name
Infectionjournal_title
Infectionauthors
Falkenberg FW,Mondorf AWdoi
10.1007/BF01650513subject
Has Abstractpub_date
1988-01-01 00:00:00pages
S69-75eissn
0300-8126issn
1439-0973journal_volume
16 Suppl 1pub_type
杂志文章相关文献
INFECTION文献大全abstract::Cefotaxime is an effective antibiotic in lower respiratory tract infection caused by streptococci and staphylococci. There is a limited tendency to superinfections with Pseudomonas aeruginosa (1.5%) and there is a low incidence of side-effects. It is questionable whether there is really an urgent need for cefotaxime i...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01644213
更新日期:1985-01-01 00:00:00
abstract::The purpose of this study was to determine the effectiveness and tolerability of norfloxacin, cinoxacin and oxolinic acid in the treatment of urinary tract infections (UTI) in comparison to nalidixic acid. 125 patients were given the drugs in the appropriate doses for 10-14 days and 30 patients were treated for six we...
journal_title:Infection
pub_type: 临床试验,杂志文章
doi:10.1007/BF01645218
更新日期:1984-11-01 00:00:00
abstract:OBJECTIVES:Current guidelines provide limited evidence as to which patients with urinary tract infection (UTI) require hospitalisation. We evaluated the currently used triage routine and tested whether a set of criteria including biomarkers like proadrenomedullin (proADM) and urea have the potential to improve triage d...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-013-0423-1
更新日期:2013-08-01 00:00:00
abstract::The original version of this article unfortunately contained a mistake. The given name and family name of Filippo Parretti was transposed in the original publication. The correct name is as shown above. ...
journal_title:Infection
pub_type: 杂志文章,已发布勘误
doi:10.1007/s15010-019-01283-9
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:In a study involving 200 patients, we previously found that 17.5% of patients developed viridans streptococcal (VS) bacteremia following autologous peripheral blood stem cell transplantation (aPBSCT) when ciprofloxacin or ciprofloxacin plus ampicillin was used for prophylaxis. PATIENTS AND METHODS:A retrosp...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-001-1028-7
更新日期:2001-08-01 00:00:00
abstract::A case of appendicitis followed by reactive arthritis in an HLA B27-positive, 29-year-old man after infection with Yersinia enterocolitica is reported. Infection with Y. enterocolitica was diagnosed by determination of serotype specific antibodies and antibodies to Yersinia outer membrane proteins. Bacteriological cul...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01720409
更新日期:1997-09-01 00:00:00
abstract::The detection of cryptococcal polysaccharides in the serum is diagnostic of cryptococcosis in the absence of rheumatoid factor. The significance of the continued detection of this antigen in the serum during antifungal therapy is not known. Prolonged antigenemia might indicate ongoing active infection, delayed clearan...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01641291
更新日期:1983-05-01 00:00:00
abstract::Three parameters--urinary symptoms, pyuria, and bacteriuria--can be used independently or in combination to define the presence of urinary tract infection. Using these parameters, several approaches to defining urinary infection in various clinical contexts are discussed. Similarly, approaches to the definition and cl...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01704358
更新日期:1992-01-01 00:00:00
abstract::Circulatory secretory non-pancreatic phospholipase A2 (snp-PLA2) was measured prospectively at the onset (day 0) of severe sepsis in 52 patients as well as on day 1 and 2 in 25 patients, in order to answer two questions: 1) does the snp-PLA2 plasma concentration differ according to the type and severity of infection? ...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01713312
更新日期:1996-03-01 00:00:00
abstract::Interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor alpha (TNF) are important mediators of fever and inflammation, and are involved in the pathogenesis of sepsis. There is only limited data on serum concentrations of these proinflammatory cytokines in patients with feve...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01716695
更新日期:1994-05-01 00:00:00
abstract::High serum levels of procalcitonin (PCT) are observed in patients with sepsis or severe infection. In a prospective study of 122 hospitalised adult medical patients with sepsis, serum PCT was determined on admission and for 9 days thereafter. Patients with no alteration in their immune system showed high PCT values up...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01713044
更新日期:1996-11-01 00:00:00
abstract::A guinea pig model of experimental Pseudomonas aeruginosa pneumonia was used to evaluate factors affecting the efficacy of passive immune therapy with Psomaglobin N, a hyperimmune P. aeruginosa globulin. Animals treated 2 h after infection with a single intravenous infusion of Psomaglobin N, 500 mg/kg, demonstrated 33...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01644192
更新日期:1987-01-01 00:00:00
abstract::The cephalosporins differ in the substituents attached at the 3 and/or 7 positions of the molecule. Very schematically, substitution at C3 mainly modifies the overall pharmacokinetic properties whereas substitution at position 7 influences the antibacterial characteristics. When using the more common "generation" syst...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/BF01645535
更新日期:1991-01-01 00:00:00
abstract::After briefly reviewing the earlier methods used to monitor the microbial load of returned lunar material, the author reports the more accurate research on the ability of terrestrial organisms to grow under simulated Martian environments. The possible importance of anaerobic microbiology can readily be seen because of...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01639903
更新日期:1980-01-01 00:00:00
abstract:PURPOSE:To describe the demographic, clinical, and microbiological profile of native vertebral osteomyelitis (NVO) in aged patients as compared to that of younger patients, to identify differences that could motivate changes in clinical management. METHODS:Retrospective, observational cohort study (1990-2015) includin...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-018-1177-6
更新日期:2018-10-01 00:00:00
abstract:PURPOSE:To assess incidence rate, risk factors and susceptibility patterns associated with extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli or Klebsiella pneumoniae in community-acquired urinary tract infections (CA-UTIs). METHODS:A prospective, case-control study was conducted at a tertiary teaching...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-018-1148-y
更新日期:2018-08-01 00:00:00
abstract:PURPOSE:In January 2015, we noticed by rectal swab analyses that seven of 23 patients at an early rehabilitation ward had been colonized with carbapenem-resistant Klebsiella pneumoniae (CKP). Here, we describe risk factors for CKP acquisition. METHODS:In the present study, the outbreak is described and risk factors fo...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-017-1103-3
更新日期:2018-02-01 00:00:00
abstract::Cefodizime was evaluated for its effect on a number of parameters of leukocyte function in humans. Four healthy volunteers received 2 g i.v. b.i.d. for seven days. Leukocyte activity was measured before, during and after treatment. Using opsonized zymosan as a stimulant, no effect on the respiratory burst of granulocy...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01709952
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Viral hepatitis is characterized by special clinical, biochemical and serological findings. This study was planned to determine the seroprevalence, epidemiological characteristics and clinical and biochemical findings of hepatitis A virus (HAV) and hepatitis E virus (HEV) infections during an outbreak of jau...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-002-2123-0
更新日期:2002-12-01 00:00:00
abstract::The original version of this article unfortunately contained a mistake. ...
journal_title:Infection
pub_type: 已发布勘误
doi:10.1007/s15010-020-01463-y
更新日期:2020-08-01 00:00:00
abstract::We describe two splenectomized patients admitted with pneumonia. The course in one was complicated by overwhelming multiorgan failure when the only indicative laboratory result was seropositivity for Legionella hackeliae and Legionella longbeachae. He was initially treated with ceftriaxone and roxithromycin, followed ...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-004-3005-4
更新日期:2004-06-01 00:00:00
abstract::Ten patients about to undergo a colorectal operation lasting an average of three hours received 500 mg each of imipenem and cilastatin i.v. preoperatively. During the operation blood and tissue samples were taken in order to determine the serum kinetics of the substances as well as the levels of imipenem in the cutis,...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01646409
更新日期:1990-11-01 00:00:00
abstract::A case of meningitis due to an unusual organism, Haemophilus aphrophilus in an adult is described. In spite of rapid clearance of the organism from the cerebrospinal fluid with intravenous cefotaxime, fever persisted over 8 days of therapy and infection was complicated by hydrocephalus. H. aphrophilus meningitis is un...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF02770846
更新日期:1998-11-01 00:00:00
abstract::Mycobacterium kansasii infection is a recognized complication of AIDS and a broad spectrum of extrapulmonary manifestations has been reported. However, AIDS-related M. kansasii pericarditis is an extremely rare disease. We report the first European case of this infection, that presented some different clinical finding...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-001-0061-x
更新日期:2001-01-01 00:00:00
abstract::In 40 intensive care patients, tissue oxygen partial pressure distribution within skeletal muscle was measured in order to estimate peripheral oxygen availability. In septic patients with multiple organ failure (n = 20) mean skeletal muscle pO2 was abnormally high (48.8 +/- 8.5 mmHg, p less than 0.001) in contrast to ...
journal_title:Infection
pub_type: 临床试验,杂志文章
doi:10.1007/BF01645355
更新日期:1991-09-01 00:00:00
abstract::The clinical tolrance of 350 mg pivampicillin tablets was evaluated in 470 hospitalized patients in Denmark, Norway and Iceland. The tablets were given to 229 fasting patients and to 241 non-fasting patients at mealtime. Side-effects were reported in 44 patients (9.4%). Upper gastro intestinal disturbances occurred in...
journal_title:Infection
pub_type: 临床试验,杂志文章
doi:10.1007/BF01639105
更新日期:1977-01-01 00:00:00
abstract::Fusobacterium nucleatum is an anaerobic Gram-negative bacillus commensal to the human oropharynx and gastrointestinal tract which causes an array of human infection, yet it has never been associated with infection of prosthetic joints. We report the first case of prosthetic hip infection caused by F. nucleatum in a ma...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-011-0197-2
更新日期:2012-06-01 00:00:00
abstract::A microbiological analysis of 102 patients suffering from cystic fibrosis was conducted over a 22 month period. 20 microbial species with the following incidence were identified: Pseudomonas aeruginosa: 83.4%; Candida albicans: 29.4%; Staphylococcus aureus: 24.5%; Staphylococcus epidermidis: 11.8%; Haemophilus influen...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01644137
更新日期:1987-07-01 00:00:00
abstract:BACKGROUND:Current data on the risk of transmission of 2009 H1N1 Influenza in public transportation systems (e.g., public trains, busses, airplanes) are conflicting. The main transmission route of this virus is thought to be via droplets, but airborne transmission has not been completely ruled out. METHODS:This is a c...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-011-0084-x
更新日期:2011-04-01 00:00:00
abstract::A rare case of spontaneous spondylodiscitis caused by Klebsiella pneumoniae in a 55-year-old man who presented with thoracolumbar pain is described. Increased erythrocyte sedimentation rate and C-reactive protein level were pertinent laboratory findings. Computed tomography revealed a paravertebral mass and destructio...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s150100050046
更新日期:1999-11-01 00:00:00