当前位置： SCI文献检索 > Nature Communications期刊下所有文献 > circNDUFB2 inhibits non-small cell lung cancer progression via destabilizing IGF2BPs and activating anti-tumor immunity.

circNDUFB2 inhibits non-small cell lung cancer progression via destabilizing IGF2BPs and activating anti-tumor immunity.

Abstract：

:Circular RNAs (circRNA) are a class of covalently closed single-stranded RNAs that have been implicated in cancer progression. Here we identify circNDUFB2 to be downregulated in non-small cell lung cancer (NSCLC) tissues, and to negatively correlate with NSCLC malignant features. Elevated circNDUFB2 inhibits growth and metastasis of NSCLC cells. Mechanistically, circNDUFB2 functions as a scaffold to enhance the interaction between TRIM25 and IGF2BPs, a positive regulator of tumor progression and metastasis. This TRIM25/circNDUFB2/IGF2BPs ternary complex facilitates ubiquitination and degradation of IGF2BPs, with this effect enhanced by N6-methyladenosine (m6A) modification of circNDUFB2. Moreover, circNDUFB2 is also recognized by RIG-I to activate RIG-I-MAVS signaling cascades and recruit immune cells into the tumor microenvironment (TME). Our data thus provide evidences that circNDUFB2 participates in the degradation of IGF2BPs and activation of anti-tumor immunity during NSCLC progression via the modulation of both protein ubiquitination and degradation, as well as cellular immune responses.

journal_name

Nat Commun

journal_title

Nature communications

authors

Li B,Zhu L,Lu C,Wang C,Wang H,Jin H,Ma X,Cheng Z,Yu C,Wang S,Zuo Q,Zhou Y,Wang J,Yang C,Lv Y,Jiang L,Qin W

doi

10.1038/s41467-020-20527-z

subject

Has Abstract

pub_date

2021-01-12 00:00:00

pages

295

issue

1

issn

2041-1723

pii

10.1038/s41467-020-20527-z

journal_volume

12

pub_type

杂志文章

相关文献

Nature Communications文献大全
  • Non defect-stabilized thermally stable single-atom catalyst.

    abstract：:Surface-supported isolated atoms in single-atom catalysts (SACs) are usually stabilized by diverse defects. The fabrication of high-metal-loading and thermally stable SACs remains a formidable challenge due to the difficulty of creating high densities of underpinning stable defects. Here we report that isolated Pt ato...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-08136-3

    authors： Lang R,Xi W,Liu JC,Cui YT,Li T,Lee AF,Chen F,Chen Y,Li L,Li L,Lin J,Miao S,Liu X,Wang AQ,Wang X,Luo J,Qiao B,Li J,Zhang T

    更新日期：2019-01-16 00:00:00

  • High-power lithium-selenium batteries enabled by atomic cobalt electrocatalyst in hollow carbon cathode.

    abstract：:Selenium cathodes have attracted considerable attention due to high electronic conductivity and volumetric capacity comparable to sulphur cathodes. However, practical development of lithium-selenium batteries has been hindered by the low selenium reaction activity with lithium, high volume changes and rapid capacity f...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-18820-y

    authors： Tian H,Tian H,Wang S,Chen S,Zhang F,Song L,Liu H,Liu J,Wang G

    更新日期：2020-10-06 00:00:00

  • Vertical eddy iron fluxes support primary production in the open Southern Ocean.

    abstract：:The primary productivity of the Southern Ocean ecosystem is limited by iron availability. Away from benthic and aeolian sources, iron reaches phytoplankton primarily when iron-rich subsurface waters enter the euphotic zone. Here, eddy-resolving physical/biogeochemical simulations of a seasonally-forced, open-Southern-...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-14955-0

    authors： Uchida T,Balwada D,P Abernathey R,A McKinley G,K Smith S,Lévy M

    更新日期：2020-02-28 00:00:00

  • Coil-globule transitions drive discontinuous volume conserving deformation in locally restrained gels.

    abstract：:The equilibrium volume of a thermoresponsive polymer gel changes dramatically across a temperature due to the coil-globule transitions of the polymers. When cofacially oriented nanosheets are embedded in such a gel, the composite gel deforms at the temperature, without changing the volume, and the response time is con...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-04533-w

    authors： Yamamoto T,Masubuchi Y,Doi M

    更新日期：2018-05-25 00:00:00

  • Electron paramagnetic resonance microscopy using spins in diamond under ambient conditions.

    abstract：:Magnetic resonance spectroscopy is one of the most important tools in chemical and bio-medical research. However, sensitivity limitations typically restrict imaging resolution to ~ 10 µm. Here we bring quantum control to the detection of chemical systems to demonstrate high-resolution electron spin imaging using the q...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-00466-y

    authors： Simpson DA,Ryan RG,Hall LT,Panchenko E,Drew SC,Petrou S,Donnelly PS,Mulvaney P,Hollenberg LCL

    更新日期：2017-09-06 00:00:00

  • Hierarchical composition of reliable recombinase logic devices.

    abstract：:A major goal of synthetic biology is to reprogram living organisms to solve pressing challenges in manufacturing, environmental remediation, and healthcare. Recombinase devices can efficiently encode complex logic in many species, yet current designs are performed on a case-by-case basis, limiting their scalability an...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-08391-y

    authors： Guiziou S,Mayonove P,Bonnet J

    更新日期：2019-01-28 00:00:00

  • Low-buoyancy thermochemical plumes resolve controversy of classical mantle plume concept.

    abstract：:The Earth's biggest magmatic events are believed to originate from massive melting when hot mantle plumes rising from the lowermost mantle reach the base of the lithosphere. Classical models predict large plume heads that cause kilometre-scale surface uplift, and narrow (100 km radius) plume tails that remain in the m...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms7960

    authors： Dannberg J,Sobolev SV

    更新日期：2015-04-24 00:00:00

  • Terminal uranium(V)-nitride hydrogenations involving direct addition or Frustrated Lewis Pair mechanisms.

    abstract：:Despite their importance as mechanistic models for heterogeneous Haber Bosch ammonia synthesis from dinitrogen and dihydrogen, homogeneous molecular terminal metal-nitrides are notoriously unreactive towards dihydrogen, and only a few electron-rich, low-coordinate variants demonstrate any hydrogenolysis chemistry. Her...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-14221-y

    authors： Chatelain L,Louyriac E,Douair I,Lu E,Tuna F,Wooles AJ,Gardner BM,Maron L,Liddle ST

    更新日期：2020-01-17 00:00:00

  • Stimulus dependent transformations between synaptic and spiking receptive fields in auditory cortex.

    abstract：:Auditory cortex neurons nonlinearly integrate synaptic inputs from the thalamus and cortex, and generate spiking outputs for simple and complex sounds. Directly comparing synaptic and spiking activity can determine whether this input-output transformation is stimulus-dependent. We employ in vivo whole-cell recordings ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-14835-7

    authors： Kim KX,Atencio CA,Schreiner CE

    更新日期：2020-02-27 00:00:00

  • Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan.

    abstract：:Lifespan is a trait of enormous personal interest. Research into the biological basis of human lifespan, however, is hampered by the long time to death. Using a novel approach of regressing (272,081) parental lifespans beyond age 40 years on participant genotype in a new large data set (UK Biobank), we here show that ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms11174

    authors： Joshi PK,Fischer K,Schraut KE,Campbell H,Esko T,Wilson JF

    更新日期：2016-03-31 00:00:00

  • Direct cellular delivery of human proteasomes to delay tau aggregation.

    abstract：:The 26S proteasome is the primary machinery that degrades ubiquitin (Ub)-conjugated proteins, including many proteotoxic proteins implicated in neurodegeneraton. It has been suggested that the elevation of proteasomal activity is tolerable to cells and may be beneficial to prevent the accumulation of protein aggregate...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms6633

    authors： Han DH,Na HK,Choi WH,Lee JH,Kim YK,Won C,Lee SH,Kim KP,Kuret J,Min DH,Lee MJ

    更新日期：2014-12-05 00:00:00

  • Blood substitution therapy rescues the brain of mice from ischemic damage.

    abstract：:Acute stroke causes complex, pathological, and systemic responses that have not been treatable by any single medication. In this study, using a murine transient middle cerebral artery occlusion stroke model, a novel therapeutic strategy is proposed, where blood replacement (BR) robustly reduces infarctions and improve...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-17930-x

    authors： Ren X,Hu H,Farooqi I,Simpkins JW

    更新日期：2020-08-25 00:00:00

  • Immunoregulation of macrophages by dynamic ligand presentation via ligand-cation coordination.

    abstract：:Macrophages regulate host responses to implants through their dynamic adhesion, release, and activation. Herein, we employ bisphosphonate (BP)-coated gold nanoparticle template (BNP) to direct the swift and convertible formation of Mg2+-functional Mg2+-BP nanoparticle (NP) on the BP-AuNP surface via reversible Mg2+-BP...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-09733-6

    authors： Kang H,Yang B,Zhang K,Pan Q,Yuan W,Li G,Bian L

    更新日期：2019-04-12 00:00:00

  • Crystal structure of human tyrosylprotein sulfotransferase-2 reveals the mechanism of protein tyrosine sulfation reaction.

    abstract：:Post-translational protein modification by tyrosine sulfation has an important role in extracellular protein-protein interactions. The protein tyrosine sulfation reaction is catalysed by the Golgi enzyme called the tyrosylprotein sulfotransferase. To date, no crystal structure is available for tyrosylprotein sulfotran...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms2593

    authors： Teramoto T,Fujikawa Y,Kawaguchi Y,Kurogi K,Soejima M,Adachi R,Nakanishi Y,Mishiro-Sato E,Liu MC,Sakakibara Y,Suiko M,Kimura M,Kakuta Y

    更新日期：2013-01-01 00:00:00

  • Accurate, scalable and integrative haplotype estimation.

    abstract：:The number of human genomes being genotyped or sequenced increases exponentially and efficient haplotype estimation methods able to handle this amount of data are now required. Here we present a method, SHAPEIT4, which substantially improves upon other methods to process large genotype and high coverage sequencing dat...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-13225-y

    authors： Delaneau O,Zagury JF,Robinson MR,Marchini JL,Dermitzakis ET

    更新日期：2019-11-28 00:00:00

  • Signature of quantum Griffiths singularity state in a layered quasi-one-dimensional superconductor.

    abstract：:Quantum Griffiths singularity was theoretically proposed to interpret the phenomenon of divergent dynamical exponent in quantum phase transitions. It has been discovered experimentally in three-dimensional (3D) magnetic metal systems and two-dimensional (2D) superconductors. But, whether this state exists in lower dim...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-07123-y

    authors： Zhang E,Zhi J,Zou YC,Ye Z,Ai L,Shi J,Huang C,Liu S,Lin Z,Zheng X,Kang N,Xu H,Wang W,He L,Zou J,Liu J,Mao Z,Xiu F

    更新日期：2018-11-07 00:00:00

  • Two-electron transfer stabilized by excited-state aromatization.

    abstract：:The scientific significance of excited-state aromaticity concerns with the elucidation of processes and properties in the excited states. Here, we focus on TMTQ, an oligomer composed of a central 1,6-methano[10]annulene and 5-dicyanomethyl-thiophene peripheries (acceptor-donor-acceptor system), and investigate a two-e...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-12986-w

    authors： Kim J,Oh J,Park S,Zafra JL,DeFrancisco JR,Casanova D,Lim M,Tovar JD,Casado J,Kim D

    更新日期：2019-11-01 00:00:00

  • Broadband on-chip single-photon spectrometer.

    abstract：:Single-photon counters are single-pixel binary devices that click upon the absorption of a photon but obscure its spectral information, whereas resolving the color of detected photons has been in critical demand for frontier astronomical observation, spectroscopic imaging and wavelength division multiplexed quantum co...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-12149-x

    authors： Cheng R,Zou CL,Guo X,Wang S,Han X,Tang HX

    更新日期：2019-09-10 00:00:00

  • Structural basis of epilepsy-related ligand-receptor complex LGI1-ADAM22.

    abstract：:Epilepsy is a common brain disorder throughout history. Epilepsy-related ligand-receptor complex, LGI1-ADAM22, regulates synaptic transmission and has emerged as a determinant of brain excitability, as their mutations and acquired LGI1 autoantibodies cause epileptic disorders in human. Here, we report the crystal stru...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-03947-w

    authors： Yamagata A,Miyazaki Y,Yokoi N,Shigematsu H,Sato Y,Goto-Ito S,Maeda A,Goto T,Sanbo M,Hirabayashi M,Shirouzu M,Fukata Y,Fukata M,Fukai S

    更新日期：2018-04-18 00:00:00

  • A variant NuRD complex containing PWWP2A/B excludes MBD2/3 to regulate transcription at active genes.

    abstract：:Transcriptional regulation by chromatin is a highly dynamic process directed through the recruitment and coordinated action of epigenetic modifiers and readers of these modifications. Using an unbiased proteomic approach to find interactors of H3K36me3, a modification enriched on active chromatin, here we identify PWW...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-06235-9

    authors： Zhang T,Wei G,Millard CJ,Fischer R,Konietzny R,Kessler BM,Schwabe JWR,Brockdorff N

    更新日期：2018-09-18 00:00:00

  • DHX36 prevents the accumulation of translationally inactive mRNAs with G4-structures in untranslated regions.

    abstract：:Translation efficiency can be affected by mRNA stability and secondary structures, including G-quadruplex structures (G4s). The highly conserved DEAH-box helicase DHX36/RHAU resolves G4s on DNA and RNA in vitro, however a systems-wide analysis of DHX36 targets and function is lacking. We map globally DHX36 binding to ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-10432-5

    authors： Sauer M,Juranek SA,Marks J,De Magis A,Kazemier HG,Hilbig D,Benhalevy D,Wang X,Hafner M,Paeschke K

    更新日期：2019-06-03 00:00:00

  • Heterologous biosynthesis and characterization of a glycocin from a thermophilic bacterium.

    abstract：:The genome of the thermophilic bacterium, Aeribacillus pallidus 8, encodes the bacteriocin pallidocin. It belongs to the small class of glycocins and is posttranslationally modified, containing an S-linked glucose on a specific Cys residue. In this study, the pallidocin biosynthetic machinery is cloned and expressed i...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-09065-5

    authors： Kaunietis A,Buivydas A,Čitavičius DJ,Kuipers OP

    更新日期：2019-03-07 00:00:00

  • Interconnect-free parallel logic circuits in a single mechanical resonator.

    abstract：:In conventional computers, wiring between transistors is required to enable the execution of Boolean logic functions. This has resulted in processors in which billions of transistors are physically interconnected, which limits integration densities, gives rise to huge power consumption and restricts processing speeds....

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms1201

    authors： Mahboob I,Flurin E,Nishiguchi K,Fujiwara A,Yamaguchi H

    更新日期：2011-02-15 00:00:00

  • Entropy production rate is maximized in non-contractile actomyosin.

    abstract：:The actin cytoskeleton is an active semi-flexible polymer network whose non-equilibrium properties coordinate both stable and contractile behaviors to maintain or change cell shape. While myosin motors drive the actin cytoskeleton out-of-equilibrium, the role of myosin-driven active stresses in the accumulation and di...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-07413-5

    authors： Seara DS,Yadav V,Linsmeier I,Tabatabai AP,Oakes PW,Tabei SMA,Banerjee S,Murrell MP

    更新日期：2018-11-23 00:00:00

  • Optical control of NMDA receptors with a diffusible photoswitch.

    abstract：:N-methyl-D-aspartate receptors (NMDARs) play a central role in synaptic plasticity, learning and memory, and are implicated in various neuronal disorders. We synthesized a diffusible photochromic glutamate analogue, azobenzene-triazole-glutamate (ATG), which is specific for NMDARs and functions as a photoswitchable ag...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms9076

    authors： Laprell L,Repak E,Franckevicius V,Hartrampf F,Terhag J,Hollmann M,Sumser M,Rebola N,DiGregorio DA,Trauner D

    更新日期：2015-08-27 00:00:00

  • Nanoscale assembly processes revealed in the nacroprismatic transition zone of Pinna nobilis mollusc shells.

    abstract：:Intricate biomineralization processes in molluscs engineer hierarchical structures with meso-, nano- and atomic architectures that give the final composite material exceptional mechanical strength and optical iridescence on the macroscale. This multiscale biological assembly inspires new synthetic routes to complex ma...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms10097

    authors： Hovden R,Wolf SE,Holtz ME,Marin F,Muller DA,Estroff LA

    更新日期：2015-12-03 00:00:00

  • PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development.

    abstract：:The precise molecular mechanism underlying the regulation of early B cell lymphopoiesis is unclear. The PLCγ signaling pathway is critical for antigen receptor-mediated lymphocyte activation, but its function in cytokine signaling is unknown. Here we show that PLCγ1/PLCγ2 double deficiency in mice blocks early B cell ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-01388-5

    authors： Yu M,Chen Y,Zeng H,Zheng Y,Fu G,Zhu W,Broeckel U,Aggarwal P,Turner A,Neale G,Guy C,Zhu N,Chi H,Wen R,Wang D

    更新日期：2017-11-13 00:00:00

  • RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency.

    abstract：:Zinc-finger nuclease, transcription activator-like effector nuclease and CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 (CRISPR-associated protein 9) are becoming major tools for genome editing. Importantly, knock-in in several non-rodent species has been finally achieved thanks to these custo...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms10548

    authors： Song J,Yang D,Xu J,Zhu T,Chen YE,Zhang J

    更新日期：2016-01-28 00:00:00

  • An unforeseen polymorph of coronene by the application of magnetic fields during crystal growth.

    abstract：:The continued development of novel drugs, proteins, and advanced materials strongly rely on our ability to self-assemble molecules in solids with the most suitable structure (polymorph) in order to exhibit desired functionalities. The search for new polymorphs remains a scientific challenge, that is at the core of cry...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms11555

    authors： Potticary J,Terry LR,Bell C,Papanikolopoulos AN,Christianen PC,Engelkamp H,Collins AM,Fontanesi C,Kociok-Köhn G,Crampin S,Da Como E,Hall SR

    更新日期：2016-05-10 00:00:00

  • CRISPR/Cas9-mediated glycolate oxidase disruption is an efficacious and safe treatment for primary hyperoxaluria type I.

    abstract：:CRISPR/Cas9 technology offers novel approaches for the development of new therapies for many unmet clinical needs, including a significant number of inherited monogenic diseases. However, in vivo correction of disease-causing genes is still inefficient, especially for those diseases without selective advantage for cor...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-07827-1

    authors： Zabaleta N,Barberia M,Martin-Higueras C,Zapata-Linares N,Betancor I,Rodriguez S,Martinez-Turrillas R,Torella L,Vales A,Olagüe C,Vilas-Zornoza A,Castro-Labrador L,Lara-Astiaso D,Prosper F,Salido E,Gonzalez-Aseguinolaza G,R

    更新日期：2018-12-21 00:00:00