Abstract:
:The actin cytoskeleton is an active semi-flexible polymer network whose non-equilibrium properties coordinate both stable and contractile behaviors to maintain or change cell shape. While myosin motors drive the actin cytoskeleton out-of-equilibrium, the role of myosin-driven active stresses in the accumulation and dissipation of mechanical energy is unclear. To investigate this, we synthesize an actomyosin material in vitro whose active stress content can tune the network from stable to contractile. Each increment in activity determines a characteristic spectrum of actin filament fluctuations which is used to calculate the total mechanical work and the production of entropy in the material. We find that the balance of work and entropy does not increase monotonically and the entropy production rate is maximized in the non-contractile, stable state of actomyosin. Our study provides evidence that the origins of entropy production and activity-dependent dissipation relate to disorder in the molecular interactions between actin and myosin.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Seara DS,Yadav V,Linsmeier I,Tabatabai AP,Oakes PW,Tabei SMA,Banerjee S,Murrell MPdoi
10.1038/s41467-018-07413-5subject
Has Abstractpub_date
2018-11-23 00:00:00pages
4948issue
1issn
2041-1723pii
10.1038/s41467-018-07413-5journal_volume
9pub_type
杂志文章abstract::Lifespan is a trait of enormous personal interest. Research into the biological basis of human lifespan, however, is hampered by the long time to death. Using a novel approach of regressing (272,081) parental lifespans beyond age 40 years on participant genotype in a new large data set (UK Biobank), we here show that ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11174
更新日期:2016-03-31 00:00:00
abstract::The interplay between superconductivity and charge-density wave (CDW) in 2H-NbSe2 is not fully understood despite decades of study. Artificially introduced disorder can tip the delicate balance between two competing long-range orders, and reveal the underlying interactions that give rise to them. Here we introduce dis...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05153-0
更新日期:2018-07-18 00:00:00
abstract::The genome of the thermophilic bacterium, Aeribacillus pallidus 8, encodes the bacteriocin pallidocin. It belongs to the small class of glycocins and is posttranslationally modified, containing an S-linked glucose on a specific Cys residue. In this study, the pallidocin biosynthetic machinery is cloned and expressed i...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09065-5
更新日期:2019-03-07 00:00:00
abstract::Metal halide perovskite semiconductors possess outstanding characteristics for optoelectronic applications including but not limited to photovoltaics. Low-dimensional and nanostructured motifs impart added functionality which can be exploited further. Moreover, wider cation composition tunability and tunable surface l...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10856-z
更新日期:2019-06-28 00:00:00
abstract::The mid-Pliocene Warm Period (mPWP) offers an opportunity to understand a warmer-than-present world and assess the predictive ability of numerical climate models. Environmental reconstruction and climate modelling are crucial for understanding the mPWP, and the synergy of these two, often disparate, fields has proven ...
journal_title:Nature communications
pub_type: 杂志文章,评审
doi:10.1038/ncomms10646
更新日期:2016-02-16 00:00:00
abstract::Amongst the rare-earth perovskite nickelates, LaNiO3 (LNO) is an exception. While the former have insulating and antiferromagnetic ground states, LNO remains metallic and non-magnetic down to the lowest temperatures. It is believed that LNO is a strange metal, on the verge of an antiferromagnetic instability. Our work...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15143-w
更新日期:2020-03-16 00:00:00
abstract::Topological insulators represent a new quantum state of matter that are insulating in the bulk but metallic on the edge or surface. In the Dirac surface state, it is well-established that the electron spin is locked with the crystal momentum. Here we report a new phenomenon of the spin texture locking with the orbital...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4382
更新日期:2014-02-28 00:00:00
abstract::The cytosolic antibody receptor TRIM21 possesses unique ubiquitination activity that drives broad-spectrum anti-pathogen targeting and underpins the protein depletion technology Trim-Away. This activity is dependent on formation of self-anchored, K63-linked ubiquitin chains by the heterodimeric E2 enzyme Ube2N/Ube2V2....
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12388-y
更新日期:2019-10-03 00:00:00
abstract::The ribosome stalls on translation of polyproline sequences due to inefficient peptide bond formation between consecutive prolines. The translation factor EF-P is able to alleviate this stalling by accelerating Pro-Pro formation. However, the mechanism by which EF-P recognizes the stalled complexes and accelerates pep...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11657
更新日期:2016-05-24 00:00:00
abstract::Sphingomyelin phosphodiesterase acid-like 3b (SMPDL3b) is a lipid raft enzyme that regulates plasma membrane (PM) fluidity. Here we report that SMPDL3b excess, as observed in podocytes in diabetic kidney disease (DKD), impairs insulin receptor isoform B-dependent pro-survival insulin signaling by interfering with insu...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10584-4
更新日期:2019-06-19 00:00:00
abstract::Chemotherapy remains a mainstay of cancer treatment but its use is often limited by the development of adverse reactions. Severe loss of body weight (cachexia) is a frequent cause of death in cancer patients and is exacerbated by chemotherapy. We show that genetic inactivation of vascular endothelial growth factor (VE...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12528
更新日期:2016-08-19 00:00:00
abstract::The dynamics of an order parameter's amplitude and phase determines the collective behaviour of novel states emerging in complex materials. Time- and momentum-resolved pump-probe spectroscopy, by virtue of measuring material properties at atomic and electronic time scales out of equilibrium, can decouple entangled deg...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1837
更新日期:2012-05-15 00:00:00
abstract::Multiferroic bismuth ferrite, BiFeO3, offers a vast landscape to study the interplay between different ferrroic orders. Another aspect which is equally exciting, and yet underutilized, is the possibility of large-scale ordering of domains. Along with symmetry-driven bulk photovoltaic effect, BiFeO3 presents opportunit...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20446-z
更新日期:2021-01-12 00:00:00
abstract::Textiles that are capable of harvesting biomechanical energy via triboelectric effects are of interest for self-powered wearable electronics. Fabrication of conformable and durable textiles with high triboelectric outputs remains challenging. Here we propose a washable skin-touch-actuated textile-based triboelectric n...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06759-0
更新日期:2018-10-15 00:00:00
abstract::The low-energy electronic excitations in graphene are described by massless Dirac fermions that have a linear dispersion relation. Taking advantage of this 'optics-like' electron dynamics, generic optical elements like lenses and wave guides have been proposed for electrons in graphene. Tuning of these elements relies...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3342
更新日期:2013-01-01 00:00:00
abstract::There are established associations between advanced paternal age and offspring risk for psychiatric and developmental disorders. These are commonly attributed to genetic mutations, especially de novo single nucleotide variants (dnSNVs), that accumulate with increasing paternal age. However, the actual magnitude of ris...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11039-6
更新日期:2019-07-10 00:00:00
abstract::Various promising qubit concepts have been put forward recently based on engineered superconductor subgap states like Andreev bound states, Majorana zero modes or the Yu-Shiba-Rusinov (Shiba) states. The coupling of these subgap states via a superconductor strongly depends on their spatial extension and is an essentia...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15322-9
更新日期:2020-04-14 00:00:00
abstract::SCRaMbLE (Synthetic Chromosome Rearrangement and Modification by LoxP-mediated Evolution) is a genome restructuring technique that can be used in synthetic genomes such as that of Sc2.0, the synthetic yeast genome, which contains hundreds to thousands of strategically positioned loxPsym sites. SCRaMbLE has been used t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04157-0
更新日期:2018-05-22 00:00:00
abstract::One prominent hallmark of topological semimetals is the existence of unusual topological surface states known as Fermi arcs. Nevertheless, the Fermi-arc superconductivity remains elusive. Here, we report the critical current oscillations from surface Fermi arcs in Nb-Dirac semimetal Cd3As2-Nb Josephson junctions. The ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15010-8
更新日期:2020-03-02 00:00:00
abstract::Human height is a representative phenotype to elucidate genetic architecture. However, the majority of large studies have been performed in European population. To investigate the rare and low-frequency variants associated with height, we construct a reference panel (N = 3,541) for genotype imputation by integrating t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12276-5
更新日期:2019-09-27 00:00:00
abstract::Modelling of non-adiabatic dynamics in extended molecular systems and solids is a next frontier of atomistic electronic structure theory. The underlying numerical algorithms should operate only with a few quantities (that can be efficiently obtained from quantum chemistry), provide a controlled approximation (which ca...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3144
更新日期:2013-01-01 00:00:00
abstract::Plasma and tumor caveolin-1 (Cav-1) are linked with disease progression in prostate cancer. Here we report that metabolomic profiling of longitudinal plasmas from a prospective cohort of 491 active surveillance (AS) participants indicates prominent elevations in plasma sphingolipids in AS progressors that, together wi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17645-z
更新日期:2020-08-27 00:00:00
abstract::Perisomatic inhibition of pyramidal neurons is established by fast-spiking, parvalbumin-expressing interneurons (PV cells). Failure to assemble adequate perisomatic inhibition is thought to underlie the aetiology of neurological dysfunction in seizures, autism spectrum disorders and schizophrenia. Here we show that in...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12829
更新日期:2016-09-09 00:00:00
abstract::Solar-driven photocatalysis has attracted significant attention in water splitting, CO2 reduction and organic synthesis. The syntheses of valuable azo- and azoxyaromatic dyes via selective photoreduction of nitroaromatic compounds have been realised using supported plasmonic metal nanoparticles at elevated temperature...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02527-8
更新日期:2018-01-04 00:00:00
abstract::Chiral metal complexes show promise as asymmetric catalysts and optical materials. Chiral-at-metal complexes composed of achiral ligands have expanded the versatility and applicability of chiral metal complexes, especially for octahedral and half-sandwich complexes. However, Werner-type tetrahedral complexes with a st...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20074-7
更新日期:2020-12-09 00:00:00
abstract::Complex behaviours may be viewed as sequences of modular actions, each elicited by specific sensory cues in their characteristic timescales. From this perspective, we can construct models in which unitary behavioural modules are hierarchically placed in context of related actions. Here, we analyse antennal positioning...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13595-3
更新日期:2019-12-06 00:00:00
abstract::Elucidating the factors governing the functional compatibility of horizontally transferred genes is important to understand bacterial evolution, including the emergence and spread of antibiotic resistance, and to successfully engineer biological systems. In silico efforts and work using single-gene libraries have sugg...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-02944-3
更新日期:2018-02-06 00:00:00
abstract::Genomic alterations occurring during melanoma progression and the resulting genomic heterogeneity between metastatic deposits remain incompletely understood. Analyzing 86 metastatic melanoma deposits from 53 patients with whole-exome sequencing (WES), we show a low branch to trunk mutation ratio and little intermetast...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05063-1
更新日期:2018-07-10 00:00:00
abstract::How rapidly natural selection sorts genome-wide standing genetic variation during adaptation remains largely unstudied experimentally. Here, we present a genomic release-recapture experiment using paired threespine stickleback fish populations adapted to selectively different lake and stream habitats. First, we use po...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15657-3
更新日期:2020-04-21 00:00:00
abstract::There is a multi-billion dollar global industry dedicated to feeding wild birds in residential gardens. This extraordinary boost to food resources is almost certainly reshaping entire bird communities, yet the large-scale, long-term impacts on community ecology remain unknown. Here we reveal a 40-year transformation o...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10111-5
更新日期:2019-05-21 00:00:00