Abstract:
BACKGROUND:On February 2, 2017, the surgical team of ten board-certified hand specialists of W Hospital in Korea successfully performed the nation's first hand transplantation at Yeungnam University Medical Center (YUMC). This paper reports on the legal, financial, and cultural hurdles that were overcome to open the way for hand transplantation and its functional outcomes at 36 months after the operation. METHODS:W Hospital formed a memorandum of understanding with Daegu city and YUMC to comply with government regulations regarding hand transplantation. Campaigns were initiated in the media to increase public awareness and understanding. With the city's financial and legal support and the university's medical cooperation, a surgical team performed a left distal forearm hand transplantation from a brain-dead 48-year-old man to a 35-year-old left-handed man. RESULTS:With this successful allotransplantation, the Korean Act on Organ Transplantation has now been amended to include hand transplantation. Korean national health insurance has also begun covering hand transplantation. Functional outcome at 36 months after the operation showed satisfactory progress in both motor and sensory functions. The disabilities of the arm, shoulder, and hand score were 23. The final Hand Transplantation Score was 90 points. Functional brain magnetic resonance imaging shows significant cortical reorganization of the corticospinal tract, and reinnervation of intrinsic muscle is observed. CONCLUSIONS:Hand transplantation at the distal forearm shows very satisfactory outcomes in functional, aesthetical, and psychological aspects. Legal and financial barriers against hand transplantation have long been the most burdensome issues. Despite this momentous success, there have been no other clinical applications of vascularized composite allotransplantation due to the limited acceptance by Korean doctors and people. Further public education campaigns for vascularized composite allotransplantation are needed to increase awareness and acceptance.
journal_name
J Korean Med Scijournal_title
Journal of Korean medical scienceauthors
Woo SH,Kim YW,Cheon HJ,Jang S,Do JY,Choi JH,Kang DH,Nam HJ,Yoo MJ,Lee YS,Choi JHdoi
10.3346/jkms.2021.36.e6subject
Has Abstractpub_date
2021-01-11 00:00:00pages
e6issue
2eissn
1011-8934issn
1598-6357pii
36.e6journal_volume
36pub_type
杂志文章abstract::1) A beta agonist stimulated Na+ transport and decreased the intracellular Cl concentration ([Cl]c) associated with cell shrinkage via an increase in cytosolic cAMP level by activating adenylate cyclase in rat fetal distal lung epithelial (FDLE) cells. 2) Lowering [Cl-]c activated a 28-pS nonselective cation (NSC) cha...
journal_title:Journal of Korean medical science
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doi:10.3346/jkms.2000.15.S.S42
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abstract:BACKGROUND:The purpose of this study was to identify the characteristics of injuries of school-aged children transported via emergency medical services (EMS) that occurred in schools by comparing with injuries that occurred outside of school. METHODS:Data from the 119 EMS from 2012 to 2014 were analyzed. School and no...
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abstract::Middle East respiratory syndrome (MERS) is a lethal respiratory disease - caused by MERS-coronavirus (MERS-CoV) which was first identified in 2012. Especially, pregnant women can be expected as highly vulnerable candidates for this viral infection. In May 2015, this virus was spread in Korea and a pregnant woman was c...
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journal_title:Journal of Korean medical science
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journal_title:Journal of Korean medical science
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doi:10.3346/jkms.2002.17.3.360
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journal_title:Journal of Korean medical science
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doi:10.3346/jkms.2011.26.6.753
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journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2005.20.4.655
更新日期:2005-08-01 00:00:00
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journal_title:Journal of Korean medical science
pub_type: 杂志文章
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journal_title:Journal of Korean medical science
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journal_title:Journal of Korean medical science
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更新日期:1996-10-01 00:00:00
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journal_title:Journal of Korean medical science
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