Abstract：
:Current and primary treatment modality in overactive bladder includes the administration of anticholinergics. The demand for new agents has been rising since anticholinergics have proven to come with many side effects. This study was designed to investigate the effects of ylang-ylang essential oil (YYEO) on the relaxation of urinary bladder muscle in vitro and in vivo. Effects of YYEO were assessed on resting tension, and electrical field stimulation- and various drug-induced contraction in vitro by checking the isometric tension changes of muscle strips and same procedures were repeated in the presence of methylene blue, Nw-Nitro-L-arginine methyl ester hydrochloride (L-NAME), or N-ethylmaleimide, and in vivo. YYEO decreased significantly the contractility of strips. There was no statistically significant difference between the treated group only with YYEO and the pretreated group with YYEO and methylene blue or L-NAME. When N-ethylmaleimide was employed, there was a statistically significant decrease in the rate of contraction. In vivo studies showed the same results compared with in vitro study. The results of this study indicate that YYEO has a relaxing effect on the bladder, and such mechanism is thought to be brought about by a pathway mediated by c-AMP.
journal_name
J Korean Med Scijournal_title
Journal of Korean medical scienceauthors
Kim HJ,Yang HM,Kim DH,Kim HG,Jang WC,Lee YRdoi
10.3346/jkms.2003.18.3.409keywords:
subject
Has Abstractpub_date
2003-06-01 00:00:00pages
409-14issue
3eissn
1011-8934issn
1598-6357pii
200306409journal_volume
18pub_type
杂志文章abstract：:We aimed to elucidate whether the eNOS T-786C mutant allele is implicated in subarachnoid hemorrhage (SAH) susceptibility or vasospasm after SAH, and whether the mutant allele is differentially expressed in those with small and large ruptured aneurysms in Korean population. 136 consecutive patients diagnosed with aneu...
journal_title：Journal of Korean medical science
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doi：10.3346/jkms.2006.21.5.922
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journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.1995.10.3.216
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journal_title：Journal of Korean medical science
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abstract：:Leptospirosis, a zoonotic disease that is caused by many serovars which are more than 200 in the world, is an emerging worldwide disease. Accurate and rapid diagnostic tests for leptospirosis are a critical step to diagnose the disease. There are some commercial kits available for diagnosis of leptospirosis, but the o...
journal_title：Journal of Korean medical science
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doi：10.3346/jkms.2016.31.2.183
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abstract：:Thoracic endovascular aortic repair (TEVAR) shows limitations in cases in which the aortic pathology involves the aortic arch. The study aims were to test a fenestrated aortic arch stent graft (FASG) with a preloaded catheter for the supraaortic arch vessels and to perform a preclinical study in swine to evaluate the ...
journal_title：Journal of Korean medical science
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journal_title：Journal of Korean medical science
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doi：10.3346/jkms.1998.13.3.234
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journal_title：Journal of Korean medical science
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doi：10.3346/jkms.2010.25.4.630
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journal_title：Journal of Korean medical science
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journal_title：Journal of Korean medical science
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doi：10.3346/jkms.2010.25.3.342
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journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.1999.14.6.629
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journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2002.17.2.279
更新日期：2002-04-01 00:00:00
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journal_title：Journal of Korean medical science
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doi：10.3346/jkms.2007.22.2.235
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doi：10.3346/jkms.2009.24.5.837
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journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2010.25.6.824
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journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2005.20.5.841
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doi：10.3346/jkms.1992.7.1.85
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journal_title：Journal of Korean medical science
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journal_title：Journal of Korean medical science
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journal_title：Journal of Korean medical science
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journal_title：Journal of Korean medical science
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doi：10.3346/jkms.2017.32.3.393
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journal_title：Journal of Korean medical science
pub_type： 杂志文章
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更新日期：1996-10-01 00:00:00
abstract：:The objective of this study was to investigate the national trends in rotator cuff surgery in Korea and analyze hospital type-specific trends. We analyzed a nationwide database acquired from the Korean Health Insurance Review and Assessment Service (HIRA) from 2007 to 2015. International Classification of Diseases, 10...
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