Abstract：
:Telomere shortening and telomerase activation occur frequently in cases of colorectal carcinoma. In this study, we correlated the clinicopathological parameters with the telomere length in colorectal carcinomas, colonic polyps, and normal colonic tissues. We also investigated whether the telomere length changes reflect the biologic behavior of tumors and different modes of tumor development. Telomere length was determined by terminal restriction fragment Southern blot analysis in 20 invasive colorectal carcinomas and normal mucosa from the same patients. We also examined 20 colonic polyps and associated normal mucosa. Telomere shortening was detected in 16/20 (80%), and telomere elongation in 2/20 (10%) cases of colorectal carcinoma, and no changes in 2 subjects. In the colonic polyp patients, shortening was detected in 4/20 (20%), elongation in 6/20 (30%), and no change in 10/20 (50%). The frequency of telomere shortening was significantly different between colorectal carcinoma and polyp groups. Decreased telomere length was noted in 92.9% (13/14) of Dukes' C and 50% (3/6) of Dukes' B. The difference between these two sub-groups was statistically significant. This study suggests that the telomere length in colorectal carcinomas is decreased upon the development of malignancy. A significant difference in telomere length between polyps and invasive colorectal carcinomas may reflect a different biologic behavior of colorectal carcinomas.
journal_name
J Korean Med Scijournal_title
Journal of Korean medical scienceauthors
Kim HR,Kim YJ,Kim HJ,Kim SK,Lee JHdoi
10.3346/jkms.2002.17.3.360keywords:
subject
Has Abstractpub_date
2002-06-01 00:00:00pages
360-5issue
3eissn
1011-8934issn
1598-6357pii
200206360journal_volume
17pub_type
杂志文章abstract：:We conducted this study to investigate the synergistic effect of human urine-derived stem cells (USCs) and surface modified composite scaffold for bladder reconstruction in a rat model. The composite scaffold (Polycaprolactone/Pluronic F127/3 wt% bladder submucosa matrix) was fabricated using an immersion precipitatio...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2015.30.12.1754
更新日期：2015-12-01 00:00:00
abstract：:This study was undertaken to evaluate the incidence and risk factors associated with relative adrenal insufficiency (RAI) in Korean critically-ill patients. All patients who were admitted to the Medical Intensive Care Unit (MICU) of Samsung Medical Center between January 1, 2006 and April 30, 2007 were prospectively e...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2009.24.4.668
更新日期：2009-08-01 00:00:00
abstract：:Protein C is the central component of a major anti-thrombotic regulatory system and individuals with hereditary protein C deficiency (PCD) tend to have an increased risk of thromboembolism. During the last several years, mutations causing PCD have been identified in Western countries and in Japanese. In the present st...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.1998.13.2.186
更新日期：1998-04-01 00:00:00
abstract：:We aimed to elucidate the effect of bilirubin on dyslipidemia and nephropathy in a diabetes mellitus (DM) type I animal model. Sprague-Dawley rats were separated into control, DM, and bilirubin-treated DM (Bil) groups. The Bil group was injected intraperitoneally with 60 mg/kg bilirubin 3 times per week and hepatoma c...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2014.29.S2.S155
更新日期：2014-09-01 00:00:00
abstract：:Increased epithelial cell proliferation is associated with an increased risk of gastric carcinoma. Helicobacter pylori infection is an established risk factor for gastric cancer and the organism has recently been classified as a group I carcinogen by an IARC working group. In this study, we describe differences in gas...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.1997.12.5.421
更新日期：1997-10-01 00:00:00
abstract：:Japanese hop (Hop J) pollen has been considered as one of the major causative pollen allergens in the autumn season. We developed a new Hop J immunotherapy extract in collaboration with Allergopharma (Reinbeck, Germany) and investigated immunologic mechanisms during 3 yr immunotherapy. Twenty patients (13 asthma with ...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2006.21.5.805
更新日期：2006-10-01 00:00:00
abstract：:Lyme disease is a vector-borne infection, primarily transmitted by Ixodes ticks, and caused by Borrelia burgdorferi. It has a wide distribution in the northern hemisphere. In Korea, however, only one human case has been reported, although B. burgdorferi was isolated from the vector tick I. persulcatus in the region. A...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.1999.14.1.85
更新日期：1999-02-01 00:00:00
abstract：:Tumor-to-tumor metastasis is rare. We report a case of metastatic renal cell carcinoma in meningioma. A 67-year-old woman presented a two-week history of motor dysphagia and decreased short-term memory. She had undergone a left radical nephrectomy for a renal cell carcinoma 7 years ago, and had not received any adjuva...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2000.15.5.593
更新日期：2000-10-01 00:00:00
abstract：:This study was performed to determine the incidence and serogroups of meningococcal disease in the Korean Army. From August 2000 to July 2001, we identified prospective cases in the Korean Army. Meningococcal disease was confirmed by isolation of Neisseria meningitidis or detection of its antigen by latex agglutinatio...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2003.18.2.163
更新日期：2003-04-01 00:00:00
abstract：:[This corrects the article e66 in vol. 34, PMID: 30833883.]. ...
journal_title：Journal of Korean medical science
pub_type： 已发布勘误
doi：10.3346/jkms.2019.34.e79
更新日期：2019-03-06 00:00:00
abstract：:Fracture of femur without evidence of severe osteoporosis rarely occurs as a result of minor external force such as a gentle passive or an active range of motion exercises. We report two cases of femoral shaft fracture occurred at the tip of heterotopic ossification of femur by a minor external force, in which the inv...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.1998.13.4.431
更新日期：1998-08-01 00:00:00
abstract：:A case of aneurysmal ("angiomatoid") fibrous histiocytoma (AFH) in a 12-year-old girl is presented with its unusual clinicopathologic features. The lesion had the full microscopic characteristics of AFH described in prior reports, but it also had some features that differed from the original description of the disorde...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.1989.4.4.159
更新日期：1989-12-01 00:00:00
abstract：BACKGROUND:Invasive bacterial infections in apparently immunocompetent children were retrospectively analyzed to figure causative bacterial organisms in Korea. METHODS:A total of 947 cases from 25 university hospitals were identified from 2006 to 2010 as a continuance of a previous 10-year period study from 1996 to 20...
journal_title：Journal of Korean medical science
pub_type： 杂志文章,多中心研究
doi：10.3346/jkms.2018.33.e45
更新日期：2018-02-05 00:00:00
abstract：:We provided a curve-fit equation to predict the normal heart weight (g) in Koreans by examining 422 autopsies (215 males and 207 females, from newborn to age 77 yr) who were relatively in good general condition. Heart weight was well correlated with body surface area (m2), body weight (kg), and body height (cm) but po...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2000.15.6.641
更新日期：2000-12-01 00:00:00
abstract：Background:We described a novel multi-step retinal fundus image reading system for providing high-quality large data for machine learning algorithms, and assessed the grader variability in the large-scale dataset generated with this system. Methods:A 5-step retinal fundus image reading tool was developed that rates im...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2018.33.e239
更新日期：2018-08-08 00:00:00
abstract：:Although the prevalence of interracial marriages in Korea is increasing, little is known regarding the pregnancy outcomes of interracial couples. The aim of this study was to investigate the differences in pregnancy outcomes between Korean and interracial Korean-foreign couples. Data for infants born in 2011 and 2012 ...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2017.32.10.1657
更新日期：2017-10-01 00:00:00
abstract：:Recent clinical trials showed that bortezomib, a novel proteasome inhibitor, had therapeutic activity in multiple myeloma. However, there was no data about the feasibility of bortezomib in Korean patients. We performed a pilot study of bortezomib in patients with relapsed or refractory myeloma (1.3 mg/m2 twice weekly ...
journal_title：Journal of Korean medical science
pub_type： 临床试验,杂志文章
doi：10.3346/jkms.2005.20.4.598
更新日期：2005-08-01 00:00:00
abstract：:We experienced two unusual cases of tumor-like polypoid lesions involving the rectosigmoid colon. They could not be readily classified into any well known polypoid tumors of the rectosigmoid colon, but appeared to have some similarities to the previously documented "eroded polypoid hyperplasia (EPH)". A collective rev...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.1994.9.4.319
更新日期：1994-08-01 00:00:00
abstract：:Human metapneumovirus (HMPV) shares clinical and epidemiological characteristics with well-known respiratory syncytial virus (RSV). The aim of this study was to investigate the clinical and epidemiological differences between HMPV- and RSV-induced wheezing illnesses. A total of 1,008 nasopharyngeal aspirate specimens ...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2010.25.3.342
更新日期：2010-03-01 00:00:00
abstract：:Atherosclerotic renal artery stenosis (RAS) usually involves the ostium and the proximal one-third of the renal artery main branch. Percutaneous renal artery angioplasty with stent placement is a well recognized treatment for atherosclerotic RAS. Occasionally, atherosclerotic RAS involves renal artery bifurcations. Ho...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2011.26.11.1512
更新日期：2011-11-01 00:00:00
abstract：:Pulmonary hypoplasia(PH) commonly occurs in association with oligohydramnios and other congenital anomalies, especially congenital diaphragmatic hernia (CDH). Pulmonary hypoplasia is an important factor, as persistent pulmonary hypertension, in the prognosis of CDH. In some reports, there is a decrement of pulmonary s...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.1996.11.3.265
更新日期：1996-06-01 00:00:00
abstract：:We aimed to investigate the clinical value of persistent but downgraded vesicoureteral reflux (VUR) after dextranomer/hyaluronic acid (Dx/HA) injection in children. The medical records of 128 children (195 ureters) who underwent Dx/HA injections for VUR were reviewed. The incidences of pre- and post-operative febrile ...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2013.28.7.1060
更新日期：2013-07-01 00:00:00
abstract：:Although little attention has been paid to the less common rheumatoid involvement of the thoracic and lumbar regions, some studies have shown that rheumatoid synovitis with erosive changes can develop in these diarthrodial joints. We report a patient with seropositive rheumatoid arthritis (RA) involving the thoracic a...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2010.25.3.472
更新日期：2010-03-01 00:00:00
abstract：:A 32-yr-old man developed progressive exertional dyspnea 4 yr after blunt chest trauma due to an automobile accident. Two-dimensional echocardiography and computed-tomographic coronary angiography demonstrated a large pseudoaneurysm of the left ventricle and severe tricuspid regurgitation. The patient underwent succes...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2012.27.4.443
更新日期：2012-04-01 00:00:00
abstract：:A 25-yr-old woman presented with a right pleural effusion. Destruction of 9th through 12th ribs, adjacent vertebral bodies, and transverse processes was noted on plain radiograph and a large low-attenuated, irregular shaped mass lesion with peripheral rim enhancement, destroying vertebral body and transverse process, ...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2002.17.6.826
更新日期：2002-12-01 00:00:00
abstract：BACKGROUND:Routine blood pressure (BP) measurement is recommended to begin at 3 years of age, but there are no national BP reference values for Korean children less than 7 years of age. Therefore, we developed sex-, age-, and height-specific BP reference values for non-overweight children aged 3-9 years. METHODS:We an...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2020.35.e91
更新日期：2020-03-30 00:00:00
abstract：:The aim of this study was to assess the effectiveness of active intervention with antenatal maternal corticosteroid and antibiotics therapy in infants delivered between 24 and 28 weeks of gestation after premature rupture of membrane. This retrospective study included pregnant women complicated by preterm delivery at ...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2005.20.1.88
更新日期：2005-02-01 00:00:00
abstract：:A collision tumor is defined by the presence of two separate masses in one organ, which are pathologically distinct. We described a 70-yr-old patient who complained of abnormal vaginal bleeding with a collision tumor of the uterine corpus. The patient received total hysterectomy, bilateral salphingo-oophorectomy, bila...
journal_title：Journal of Korean medical science
pub_type： 杂志文章,评审
doi：10.3346/jkms.2012.27.1.89
更新日期：2012-01-01 00:00:00
abstract：:The purpose of this study was to determine the feasibility of identifying the sentinel lymph nodes (SNs) as well as to evaluate factors that might influence the SN detection rate in patients with cervical cancer of the uterus. Eighty nine patients underwent intracervical injection of 1% isosulfan blue dye at the time ...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2007.22.1.105
更新日期：2007-02-01 00:00:00
abstract：:The aim of this study was to determine candidemia incidence among patients in a medical intensive-care unit (MICU) and the associated mortality rate and to identify risk factors associated with candidemia. We retrospectively performed a 1:3 matched case-control study of MICU patients with candidemia. Controls were mat...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2010.25.5.671
更新日期：2010-05-01 00:00:00
