Beta agonist regulation of sodium transport in fetal lung epithelium: roles of cell volume, cytosolic chloride and protein tyrosine kinase.

Abstract:

:1) A beta agonist stimulated Na+ transport and decreased the intracellular Cl concentration ([Cl]c) associated with cell shrinkage via an increase in cytosolic cAMP level by activating adenylate cyclase in rat fetal distal lung epithelial (FDLE) cells. 2) Lowering [Cl-]c activated a 28-pS nonselective cation (NSC) channel by elongating the open time of the channel. 3) cAMP signals were converted to a protein tyrosine kinase (PTK)-mediated signal. 4) The PTK-mediated signal was involved in the cAMP-stimulated Na+ transport in rat FDLE cells.

journal_name

J Korean Med Sci

authors

Marunaka Y,Niisato N,Ito Y

doi

10.3346/jkms.2000.15.S.S42

keywords:

subject

Has Abstract

pub_date

2000-08-01 00:00:00

pages

S42-3

eissn

1011-8934

issn

1598-6357

journal_volume

15 Suppl

pub_type

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