Abstract:
:The packaging of the eukaryotic genome into chromatin regulates the storage of genetic information, including the access of the cell's DNA metabolism machinery. Indeed, since the processes of DNA replication, translation, and repair require access to the underlying DNA, several mechanisms, both active and passive, have evolved by which chromatin structure can be regulated and modified. One mechanism relies upon the function of chromatin remodeling enzymes which couple the free energy obtained from the binding and hydrolysis of ATP to the mechanical work of repositioning and rearranging nucleosomes. Here, we review recent work on the nucleosome mobilization activity of this essential family of molecular machines.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Morgan A,LeGresley S,Fischer Cdoi
10.3390/ijms22010076subject
Has Abstractpub_date
2020-12-23 00:00:00issue
1issn
1422-0067pii
ijms22010076journal_volume
22pub_type
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journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
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