Abstract:
:Molecular dissection of hepatocellular adenomas has brought forward a diversity of well-defined entities. Their distinction is important for routine practice, since prognosis is tightly related to the individual subgroup. Very recent activity has generated new details on the molecular background of hepatocellular adenoma, which this article aims to integrate into the current concepts of taxonomy.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Goltz D,Fischer HPdoi
10.3390/ijms160920994subject
Has Abstractpub_date
2015-09-02 00:00:00pages
20994-1007issue
9issn
1422-0067pii
ijms160920994journal_volume
16pub_type
杂志文章,评审abstract::The cell membrane is a complex and highly regulated system that is composed of lipid bilayer and proteins. One of the main functions of the cell membrane is the regulation of cell entry. Cell-penetrating peptides (CPPs) are defined as peptides that can cross the plasma membrane and deliver their cargo inside the cell....
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21134719
更新日期:2020-07-02 00:00:00
abstract::Mucopolysaccharidosis IVA (MPS IVA) is caused by a deficiency of the lysosomal enzyme N-acetylgalactosamine-6-sulfate sulfatase (GALNS). Conventional enzyme replacement therapy (ERT) is approved for MPS IVA. However, the fact that the infused enzyme cannot penetrate avascular lesions in cartilage leads to minimal impa...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20174139
更新日期:2019-08-24 00:00:00
abstract::The present study aimed to elucidate how Atlantic salmon adipocytes pre-enriched with palmitic (16:0, PA), oleic (18:1n-9, OA), or eicosapentaenoic (20:5n-3, EPA) acid respond to a fasting condition mimicked by nutrient deprivation and glucagon. All experimental groups were supplemented with radiolabeled PA to trace s...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21072332
更新日期:2020-03-27 00:00:00
abstract::Distal-less homeobox 5 (Dlx5) is a negative regulator of adipogenesis. Dlx5 expression is decreased by adipogenic stimuli, but the mechanisms of Dlx5 downregulation by adipogenic stimuli have not yet been determined. Here, we tested the impact of cAMP/PKA (protein kinase A) signaling induced by 3-isobutyl-1 methyl xan...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19103161
更新日期:2018-10-14 00:00:00
abstract::The d-galactose (d-gal)-injected animal model, which is typically established by administering consecutive subcutaneous d-gal injections to animals for approximately six or eight weeks, has been frequently used for aging research. In addition, this animal model has been demonstrated to accelerate aging in the brain, k...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms17010098
更新日期:2016-01-13 00:00:00
abstract::Psoralea corylifolia L., (P. corylifolia), which is used for treating vitiligo in clinic, shows inhibitory and activating effects on tyrosinase, a rate-limiting enzyme of melanogenesis. This study aimed to determine the active ingredients in the ethenal extracts of P. corylifolia on tyrosinase activity. The spectrum-e...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19113439
更新日期:2018-11-02 00:00:00
abstract::Obesity results from an imbalance between energy intake and energy expenditure, in which excess fat is stored as triglycerides (TGs) in white adipocytes. Recent studies have explored the anti-obesity effects of certain edible phytochemicals, which suppress TG accumulation and stimulate a brown adipocyte-like phenotype...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21062153
更新日期:2020-03-20 00:00:00
abstract::Acipenseriformes are composed of 25 sturgeon species and two paddlefish species distributed exclusively in the northern hemisphere. The Danube River and the Black Sea were originally inhabited by six sturgeon species but two are extinct and only four are still reproducing currently in the Lower Danube: Huso huso, Acip...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms12106796
更新日期:2011-01-01 00:00:00
abstract::Prostate cancer (PCa), an epithelial malignant tumor, is the second common cause of cancer death among males in western countries. Thus, the development of new strategies is urgently needed. Tanshinones isolated from Salvia miltiorrhiza and its synthetic analogs show various biological activities including anticancer ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20184459
更新日期:2019-09-10 00:00:00
abstract::Metastatic melanoma is the most deadly type of skin cancer. Despite the success of immunotherapy and targeted agents, the majority of patients experience disease recurrence upon treatment and die due to their disease. Long non-coding RNAs (lncRNAs) are a new subclass of non-protein coding RNAs involved in (epigenetic)...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms18040715
更新日期:2017-03-28 00:00:00
abstract::The plant hormone auxin plays pivotal roles in many aspects of plant growth and development. The auxin/indole-3-acetic acid (Aux/IAA) gene family encodes short-lived nuclear proteins acting on auxin perception and signaling, but the evolutionary history of this gene family remains to be elucidated. In this study, the ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18102107
更新日期:2017-10-08 00:00:00
abstract::The role of dynamic processes on self-assembled structures of 4'-([2,2':6', 2''-terpyridin]-4'-yl)-[1,1'-biphenyl]-4-carboxylic acid (l) molecules on Au(III) has been studied by scanning tunneling microscopy. The as-deposited monolayer is closed-packed and periodic in a short-range due to dipole forces. A thermal anne...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms14035686
更新日期:2013-03-11 00:00:00
abstract::Cutaneous squamous cell carcinoma (CSCC) is the second most frequent cancer in humans and it can be locally invasive and metastatic to distant sites. MicroRNAs (miRNAs or miRs) are endogenous, small, non-coding RNAs of 19-25 nucleotides in length, that are involved in regulating gene expression at a post-transcription...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20092181
更新日期:2019-05-02 00:00:00
abstract::Barley (Hordeum vulgare L.) is an important cereal crop grown for both the feed and malting industries. The allelic dwarfing gene sdw1/denso has been used throughout the world to develop commercial barley varieties. Proteomic analysis offers a new approach to identify a broad spectrum of genes that are expressed in th...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms130810410
更新日期:2012-01-01 00:00:00
abstract::The synthesis of Mobil Composition of Matter 41 (MCM-41) mesoporous silica nanoparticles (MSNs) of controlled sizes and porous structure has been performed at laboratory and pilot plant scales. Firstly, the effects of the main operating conditions (TEOS -Tetraethyl ortosilicate- addition rate, nanoparticle maturation ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21217899
更新日期:2020-10-24 00:00:00
abstract::Membrane regulators such as sterols and hopanoids play a major role in the physiological and physicochemical adaptation of the different plasmic membranes in Eukarya and Bacteria. They are key to the functionalization and the spatialization of the membrane, and therefore indispensable for the cell cycle. No archaeon h...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20184434
更新日期:2019-09-09 00:00:00
abstract::Tumor necrosis factor alpha (TNF-α) is a pro-inflammatory cytokine involved in the promotion and progression of cancer, including triple negative breast cancer cells. Thus, there is significant interest in understanding the molecular signaling pathways that connect TNF-α with the survival of tumor cells. In our experi...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms14010411
更新日期:2012-12-24 00:00:00
abstract::Melanin is an important phenolic skin pigment found throughout the animal kingdom. Tyrosine and its hydroxylated product dopa provide the starting material for melanin biosynthesis in all animals. Through a set of well-established reactions, they are converted to 5,6-dihydroxyindole (DHI) and DHI-2-carboxylic acid (DH...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21197321
更新日期:2020-10-03 00:00:00
abstract::Ionic liquids (ILs), entirely composed of cations and anions, are liquid solvents at room temperature. They are interesting due to their low vapor pressure, high polarity and thermostability, and also for the possibility to fine-tune their physicochemical properties through modification of the chemical structures of t...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms150712196
更新日期:2014-07-09 00:00:00
abstract::Under acidic conditions and at high ionic strength, the zinc cation is removed from its metal complex with 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrin (TPPS4) thus leading to the diacid free porphyrin, that subsequently self-organize into J-aggregates. The kinetics of the demetallation step and the successive supr...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21114001
更新日期:2020-06-03 00:00:00
abstract::The rapid development of new generation sequencing technology has deepened the understanding of genomes and functional products. RNA-sequencing studies in mammals show that approximately 85% of the DNA sequences have RNA products, for which the length greater than 200 nucleotides (nt) is called long non-coding RNAs (l...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms18122659
更新日期:2017-12-08 00:00:00
abstract::Nitric oxide (NO/cyclic guanosine monophosphate (cGMP)-regulated cellular mechanisms are involved in a variety of (patho-) physiological processes. One of the main effector molecules in this system, proteinkinase G (PKG), serves as a molecular switch by phosphorylating different target proteins and thereby turning the...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19041180
更新日期:2018-04-12 00:00:00
abstract::Vascular calcification, which involves the deposition of calcifying particles within the arterial wall, is mediated by atherosclerosis, vascular smooth muscle cell osteoblastic changes, adventitial mesenchymal stem cell osteoblastic differentiation, and insufficiency of the calcification inhibitors. Recent observation...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21072466
更新日期:2020-04-02 00:00:00
abstract::The engineering of T cells through expression of chimeric antigen receptors (CARs) against tumor-associated antigens (TAAs) has shown significant potential for use as an anti-cancer therapeutic. The development of strategies for flexible and modular CAR T systems is accelerating, allowing for multiple antigen targetin...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21197222
更新日期:2020-09-30 00:00:00
abstract::Epithelial cell adhesion molecule (EpCAM) is overexpressed in 55%-75% of ovarian carcinomas (OC). EpCAM might be used as a target for a treatment of disseminated OC. Designed ankyrin repeats protein (DARPin) Ec1 is a small (18 kDa) protein, which binds to EpCAM with subnanomolar affinity. We tested a hypothesis that E...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21093310
更新日期:2020-05-07 00:00:00
abstract::The basal forebrain is home to the largest population of cholinergic neurons in the brain. These neurons are involved in a number of cognitive functions including attention, learning and memory. Basal forebrain cholinergic neurons (BFCNs) are particularly vulnerable in a number of neurological diseases with the most n...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms17122122
更新日期:2016-12-17 00:00:00
abstract::The dimension of the plants largest organelle-the vacuole-plays a major role in defining cellular elongation rates. The morphology of the vacuole is controlled by the actin cytoskeleton, but molecular players remain largely unknown. Recently, the Networked (NET) family of membrane-associated, actin-binding proteins ha...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20194752
更新日期:2019-09-25 00:00:00
abstract::In this paper, we used a Genotyping-by-Sequencing (GBS) approach to find and genotype more than 4000 genome-wide SNPs (Single Nucleotide Polymorphisms) from striped killifish exposed to a variety of polychlorinated biphenyls (PCBs) and other aromatic pollutants in New Bedford Harbor (NBH, Massachusetts, USA). The aims...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20051129
更新日期:2019-03-05 00:00:00
abstract::Immunotherapy in cancer patients is a very promising treatment and the development of new protocols and the study of the mechanisms of regression is imperative. The objective of this study was to evaluate the production of cytokines in helper T (CD4+) lymphocytes during immunotherapy with pegylated IFN-α in patients w...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms16035497
更新日期:2015-03-10 00:00:00
abstract::DNA topoisomerase II (TOP2) activity involves a normally transient double-strand break intermediate in which the enzyme is coupled to DNA via a 5'-phosphotyrosyl bond. However, etoposide and other topoisomerase drugs poison the enzyme by stabilising this enzyme-bridged break, resulting in the accumulation of TOP2-DNA ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19072056
更新日期:2018-07-14 00:00:00