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Immunopathology, host-virus genome interactions, and effective vaccine development in SARS-CoV-2.

Abstract：

:Coronaviruses are a group of enveloped RNA viruses that are diversely found in humans and now declared a global pandemic by the World Health Organization in March 2020. The population's susceptibility to these highly pathogenic coronaviruses has contributed to large outbreaks, evolved into public health events, and rapidly transmitted globally. Thus, there is an urgent need to develop effective therapies and vaccines against this disease. In the primary stage of severe acute respiratory syndrome coronavirus (SARS-COV-2) infection, the signs and symptoms are nonspecific, and many more cases have been observed than initially expected. Genome sequencing is performed regularly to identify genetic changes to SARS-COV-2, and vaccine development is focused on manufacture, production, and based on specific problems, and very few are available on recent developments in the prevention of outbreaks. The aim of this review article to explore recent updates on SARS-COV-2 in the context of pathogenesis during disease progression, and innate acquired mechanisms of defense, This includes advances in diagnostics, susceptibility, and severity of host-virus genome interactions, modes of transmission, active compounds being used in pre-clinical and clinical trials for the treatment of patients, vaccine developments, and the effectiveness of SARS-COV-2 prevention and control measures. We have summarized the importance of pathophysiology immune response, Diagnostics, vaccine development currently approaches explored for SARS-COV-2.

journal_name

Comput Struct Biotechnol J

journal_title

Computational and structural biotechnology journal

authors

Singh DD,Han I,Choi EH,Yadav DK

doi

10.1016/j.csbj.2020.11.011

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

3774-3787

issn

2001-0370

pii

S2001-0370(20)30478-5

journal_volume

18

pub_type

杂志文章,评审

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