听力与言语-语言病理学

行为科学

医学伦理学

你正在浏览Computational and Structural Biotechnology Journal期刊下所有文献
  • Managing children with brain tumors during the COVID-19 era: Don't stop the care!

    abstract::The COVID-19 pandemic has substantially stressed health care systems globally, subsequently reducing cancer care services and delaying treatments. Pediatric populations infected by COVID-19 have shown mild clinical symptoms compared to adults, perhaps due to decreased susceptibility. Several scientific societies and g...

    journal_title:Computational and structural biotechnology journal

    pub_type: 杂志文章,评审

    doi:10.1016/j.csbj.2021.01.005

    authors: Capozza MA,Triarico S,Attinà G,Romano A,Mastrangelo S,Maurizi P,Frassanito P,Bianchi F,Verdolotti T,Gessi M,Balducci M,Massimi L,Tamburrini G,Ruggiero A,Gemelli Pediatric Neuro-Oncology Tumor Board.

    更新日期:2021-01-12 00:00:00

  • Identification and characterisation of putative drug binding sites in human ATP-binding cassette B5 (ABCB5) transporter.

    abstract::The human ATP-binding cassette B5 (ABCB5) transporter, a member of the ABC transporter superfamily, is linked to chemoresistance in tumour cells by drug effluxion. However, little is known about its structure and drug-binding sites. In this study, we generated an atomistic model of the full-length human ABCB5 transpor...

    journal_title:Computational and structural biotechnology journal

    pub_type: 杂志文章

    doi:10.1016/j.csbj.2020.12.042

    authors: Tangella LP,Arooj M,Deplazes E,Gray ES,Mancera RL

    更新日期:2020-12-30 00:00:00

  • Virulence factor-related gut microbiota genes and immunoglobulin A levels as novel markers for machine learning-based classification of autism spectrum disorder.

    abstract::Autism spectrum disorder (ASD) is a neurodevelopmental condition for which early identification and intervention is crucial for optimum prognosis. Our previous work showed gut Immunoglobulin A (IgA) to be significantly elevated in the gut lumen of children with ASD compared to typically developing (TD) children. Gut m...

    journal_title:Computational and structural biotechnology journal

    pub_type: 杂志文章

    doi:10.1016/j.csbj.2020.12.012

    authors: Wang M,Doenyas C,Wan J,Zeng S,Cai C,Zhou J,Liu Y,Yin Z,Zhou W

    更新日期:2020-12-29 00:00:00

  • Nasal microbiome research in ANCA-associated vasculitis: Strengths, limitations, and future directions.

    abstract::The human nasal microbiome is characterized by biodiversity and undergoes changes during the span of life. In granulomatosis with polyangiitis (GPA), the persistent nasal colonization by Staphylococcus aureus (S. aureus) assessed by culture-based detection methods has been associated with increased relapse frequency. ...

    journal_title:Computational and structural biotechnology journal

    pub_type: 杂志文章,评审

    doi:10.1016/j.csbj.2020.12.031

    authors: Kronbichler A,Harrison EM,Wagner J

    更新日期:2020-12-27 00:00:00

  • Alternative splicing: Human disease and quantitative analysis from high-throughput sequencing.

    abstract::Alternative splicing contributes to the majority of protein diversity in higher eukaryotes by allowing one gene to generate multiple distinct protein isoforms. It adds another regulation layer of gene expression. Up to 95% of human multi-exon genes undergo alternative splicing to encode proteins with different functio...

    journal_title:Computational and structural biotechnology journal

    pub_type: 杂志文章,评审

    doi:10.1016/j.csbj.2020.12.009

    authors: Jiang W,Chen L

    更新日期:2020-12-24 00:00:00

  • The impact of Gag non-cleavage site mutations on HIV-1 viral fitness from integrative modelling and simulations.

    abstract::The high mutation rate in retroviruses is one of the leading causes of drug resistance. In human immunodeficiency virus type-1 (HIV-1), synergistic mutations in its protease and the protease substrate - the Group-specific antigen (Gag) polyprotein - work together to confer drug resistance against protease inhibitors a...

    journal_title:Computational and structural biotechnology journal

    pub_type: 杂志文章

    doi:10.1016/j.csbj.2020.12.022

    authors: Samsudin F,Gan SK,Bond PJ

    更新日期:2020-12-23 00:00:00

  • FangNet: Mining herb hidden knowledge from TCM clinical effective formulas using structure network algorithm.

    abstract::The use of herbs to treat various human diseases has been recorded for thousands of years. In Asia's current medical system, numerous herbal formulas have been repeatedly verified to confirm their effectiveness in different periods, which is a great resource for drug innovation and discovery. Through the mining of the...

    journal_title:Computational and structural biotechnology journal

    pub_type: 杂志文章

    doi:10.1016/j.csbj.2020.11.036

    authors: Bu D,Xia Y,Zhang J,Cao W,Huo P,Wang Z,He Z,Ding L,Wu Y,Zhang S,Gao K,Yu H,Liu T,Ding X,Gu X,Zhao Y

    更新日期:2020-12-04 00:00:00

  • Combining Ramachandran plot and molecular dynamics simulation for structural-based variant classification: Using TP53 variants as model.

    abstract::The wide application of new DNA sequencing technologies is generating vast quantities of genetic variation data at unprecedented speed. Developing methodologies to decode the pathogenicity of the variants is imperatively demanding. We hypothesized that as deleterious variants may function through disturbing structural...

    journal_title:Computational and structural biotechnology journal

    pub_type: 杂志文章

    doi:10.1016/j.csbj.2020.11.041

    authors: Tam B,Sinha S,Wang SM

    更新日期:2020-12-02 00:00:00

  • Structure-based discovery of neoandrographolide as a novel inhibitor of Rab5 to suppress cancer growth.

    abstract::Rab5 is a small GTPase that plays a crucial role in oncogenic signal transduction, which was considered as an attractive target for cancer therapy. Rapid GDP/GTP exchange in the packet of Rab5 sustains its high activity for promoting cancer progression. However, Rab5 currently remains undruggable due to the lack of sp...

    journal_title:Computational and structural biotechnology journal

    pub_type: 杂志文章

    doi:10.1016/j.csbj.2020.11.033

    authors: Zhang J,Sun Y,Zhong LY,Yu NN,Ouyang L,Fang RD,Wang Y,He QY

    更新日期:2020-11-30 00:00:00

  • Fungi.guru: Comparative genomic and transcriptomic resource for the fungi kingdom.

    abstract::The fungi kingdom is composed of eukaryotic heterotrophs, which are responsible for balancing the ecosystem and play a major role as decomposers. They also produce a vast diversity of secondary metabolites, which have antibiotic or pharmacological properties. However, our lack of knowledge of gene function in fungi pr...

    journal_title:Computational and structural biotechnology journal

    pub_type: 杂志文章

    doi:10.1016/j.csbj.2020.11.019

    authors: Lim JJJ,Koh J,Moo JR,Villanueva EMF,Putri DA,Lim YS,Seetoh WS,Mulupuri S,Ng JWZ,Nguyen NLU,Reji R,Foo H,Zhao MX,Chan TL,Rodrigues EE,Kairon RS,Hee KM,Chee NC,Low AD,Chen ZHX,Lim SC,Lunardi V,Fong TC,Chua CX

    更新日期:2020-11-20 00:00:00

  • Ancestral zinc-finger bearing protein MucR in alpha-proteobacteria: A novel xenogeneic silencer?

    abstract::The MucR/Ros family protein is conserved in alpha-proteobacteria and characterized by its zinc-finger motif that has been proposed as the ancestral domain from which the eukaryotic C2H2 zinc-finger structure evolved. In the past decades, accumulated evidences have revealed MucR as a pleiotropic transcriptional regulat...

    journal_title:Computational and structural biotechnology journal

    pub_type: 杂志文章,评审

    doi:10.1016/j.csbj.2020.11.028

    authors: Jiao J,Tian CF

    更新日期:2020-11-19 00:00:00

  • Homology modeling in the time of collective and artificial intelligence.

    abstract::Homology modeling is a method for building protein 3D structures using protein primary sequence and utilizing prior knowledge gained from structural similarities with other proteins. The homology modeling process is done in sequential steps where sequence/structure alignment is optimized, then a backbone is built and ...

    journal_title:Computational and structural biotechnology journal

    pub_type: 杂志文章,评审

    doi:10.1016/j.csbj.2020.11.007

    authors: Hameduh T,Haddad Y,Adam V,Heger Z

    更新日期:2020-11-14 00:00:00

  • Allosteric inhibition explained through conformational ensembles sampling distinct "mixed" states.

    abstract::Allosteric modulation provides an effective avenue for selective and potent enzyme inhibition. Here, we summarize and critically discuss recent advances on the mechanisms of allosteric partial agonists for three representative signalling enzymes activated by cyclic nucleotides: the cAMP-dependent protein kinase (PKA),...

    journal_title:Computational and structural biotechnology journal

    pub_type: 杂志文章,评审

    doi:10.1016/j.csbj.2020.10.026

    authors: Byun JA,VanSchouwen B,Akimoto M,Melacini G

    更新日期:2020-11-11 00:00:00

  • The ecogenomics of dsDNA bacteriophages in feces of stabled and feral horses.

    abstract::The viromes of the mammalian lower gut were shown to be heavily dominated by bacteriophages; however, only for humans were the composition and intervariability of the bacteriophage communities studied in depth. Here we present an ecogenomics survey of dsDNA bacteriophage diversity in the feces of horses (Equus caballu...

    journal_title:Computational and structural biotechnology journal

    pub_type: 杂志文章

    doi:10.1016/j.csbj.2020.10.036

    authors: Babenko VV,Millard A,Kulikov EE,Spasskaya NN,Letarova MA,Konanov DN,Belalov IS,Letarov AV

    更新日期:2020-11-10 00:00:00

  • Reactive oxygen species: A generalist in regulating development and pathogenicity of phytopathogenic fungi.

    abstract::Reactive oxygen species (ROS) are small molecules with high oxidative activity, and are usually produced as byproducts of metabolic processes in organisms. ROS play an important role during the interaction between plant hosts and pathogenic fungi. Phytopathogenic fungi have evolved sophisticated ROS producing and scav...

    journal_title:Computational and structural biotechnology journal

    pub_type: 杂志文章,评审

    doi:10.1016/j.csbj.2020.10.024

    authors: Zhang Z,Chen Y,Li B,Chen T,Tian S

    更新日期:2020-11-04 00:00:00

  • The era of big data: Genome-scale modelling meets machine learning.

    abstract::With omics data being generated at an unprecedented rate, genome-scale modelling has become pivotal in its organisation and analysis. However, machine learning methods have been gaining ground in cases where knowledge is insufficient to represent the mechanisms underlying such data or as a means for data curation prio...

    journal_title:Computational and structural biotechnology journal

    pub_type: 杂志文章,评审

    doi:10.1016/j.csbj.2020.10.011

    authors: Antonakoudis A,Barbosa R,Kotidis P,Kontoravdi C

    更新日期:2020-10-16 00:00:00

  • Dynamic exchange of two types of stator units in Bacillus subtilis flagellar motor in response to environmental changes.

    abstract::Bacteria can migrate towards more suitable environments by rotating flagella that are under the control of sensory signal transduction networks. The bacterial flagellum is composed of the long helical filament functioning as a propeller, the flexible hook as a universal joint and the basal body as a rotary motor power...

    journal_title:Computational and structural biotechnology journal

    pub_type: 杂志文章,评审

    doi:10.1016/j.csbj.2020.10.009

    authors: Terahara N,Namba K,Minamino T

    更新日期:2020-10-15 00:00:00

  • Experimental determination and data-driven prediction of homotypic transmembrane domain interfaces.

    abstract::Interactions between their transmembrane domains (TMDs) frequently support the assembly of single-pass membrane proteins to non-covalent complexes. Yet, the TMD-TMD interactome remains largely uncharted. With a view to predicting homotypic TMD-TMD interfaces from primary structure, we performed a systematic analysis o...

    journal_title:Computational and structural biotechnology journal

    pub_type: 杂志文章

    doi:10.1016/j.csbj.2020.09.035

    authors: Xiao Y,Zeng B,Berner N,Frishman D,Langosch D,George Teese M

    更新日期:2020-10-07 00:00:00

  • Experimental and computational analysis of biased agonism on full-length and a C-terminally truncated adenosine A2A receptor.

    abstract::Biased agonism, the ability of agonists to differentially activate downstream signaling pathways by stabilizing specific receptor conformations, is a key issue for G protein-coupled receptor (GPCR) signaling. The C-terminal domain might influence this functional selectivity of GPCRs as it engages G proteins, GPCR kina...

    journal_title:Computational and structural biotechnology journal

    pub_type: 杂志文章

    doi:10.1016/j.csbj.2020.09.028

    authors: Navarro G,Gonzalez A,Campanacci S,Rivas-Santisteban R,Reyes-Resina I,Casajuana-Martin N,Cordomí A,Pardo L,Franco R

    更新日期:2020-09-24 00:00:00

  • A metagenome-wide association study of gut microbiome and visceral fat accumulation.

    abstract:Purpose:Visceral fat is an independent risk factor for metabolic and cardiovascular disease. The study aimed to investigate the associations between gut microbiome and visceral fat. Methods:We recruited 32 obese adults and 30 healthy controls at baseline. Among the obese subjects, 14 subjects underwent laparoscopic sl...

    journal_title:Computational and structural biotechnology journal

    pub_type: 杂志文章

    doi:10.1016/j.csbj.2020.09.026

    authors: Nie X,Chen J,Ma X,Ni Y,Shen Y,Yu H,Panagiotou G,Bao Y

    更新日期:2020-09-20 00:00:00

  • Multi-population cohort meta-analysis of human intestinal microbiota in early life reveals the existence of infant community state types (ICSTs).

    abstract::Appropriate development of the intestinal microbiota during infancy is known to be important for human health. In fact, aberrant alterations of the microbial composition during childhood may cause short- and/or long-term negative health effects. Many factors influence the initial assembly and subsequent progression of...

    journal_title:Computational and structural biotechnology journal

    pub_type: 杂志文章

    doi:10.1016/j.csbj.2020.08.028

    authors: Mancabelli L,Tarracchini C,Milani C,Lugli GA,Fontana F,Turroni F,van Sinderen D,Ventura M

    更新日期:2020-09-15 00:00:00

  • UMI-Gen: A UMI-based read simulator for variant calling evaluation in paired-end sequencing NGS libraries.

    abstract:Motivation:With Next Generation Sequencing becoming more affordable every year, NGS technologies asserted themselves as the fastest and most reliable way to detect Single Nucleotide Variants (SNV) and Copy Number Variations (CNV) in cancer patients. These technologies can be used to sequence DNA at very high depths thu...

    journal_title:Computational and structural biotechnology journal

    pub_type: 杂志文章

    doi:10.1016/j.csbj.2020.08.011

    authors: Sater V,Viailly PJ,Lecroq T,Ruminy P,Bérard C,Prieur-Gaston É,Jardin F

    更新日期:2020-08-27 00:00:00

  • A bird's-eye view of deep learning in bioimage analysis.

    abstract::Deep learning of artificial neural networks has become the de facto standard approach to solving data analysis problems in virtually all fields of science and engineering. Also in biology and medicine, deep learning technologies are fundamentally transforming how we acquire, process, analyze, and interpret data, with ...

    journal_title:Computational and structural biotechnology journal

    pub_type: 杂志文章,评审

    doi:10.1016/j.csbj.2020.08.003

    authors: Meijering E

    更新日期:2020-08-07 00:00:00

  • A molecular device: A DNA molecular lock driven by the nicking enzymes.

    abstract::As people are placing more and more importance on information security, how to realize the protection of information has become a hotspot of current research. As a security device, DNA molecular locks have great potential to realize information protection at the molecular level. However, building a highly secure molec...

    journal_title:Computational and structural biotechnology journal

    pub_type: 杂志文章

    doi:10.1016/j.csbj.2020.08.004

    authors: Zhang X,Zhang Q,Liu Y,Wang B,Zhou S

    更新日期:2020-08-06 00:00:00

  • Transcriptome and proteome analyses reveal the regulatory networks and metabolite biosynthesis pathways during the development of Tolypocladium guangdongense.

    abstract::Tolypocladium guangdongense has a similar metabolite profile to Ophiocordyceps sinensis, a highly regarded fungus used for traditional Chinese medicine with high nutritional and medicinal value. Although the genome sequence of T. guangdongense has been reported, relatively little is known about the regulatory networks...

    journal_title:Computational and structural biotechnology journal

    pub_type: 杂志文章

    doi:10.1016/j.csbj.2020.07.014

    authors: Wang G,Li M,Zhang C,Cheng H,Gao Y,Deng W,Li T

    更新日期:2020-07-25 00:00:00

  • AUDACITY: A comprehensive approach for the detection and classification of Runs of Homozygosity in medical and population genomics.

    abstract::Runs of Homozygosity (RoHs) are popular among geneticists as the footprint of demographic processes, evolutionary forces and inbreeding in shaping our genome, and are known to confer risk of Mendelian and complex diseases. Notwithstanding growing interest in their study, there is unmet need for reliable and rapid meth...

    journal_title:Computational and structural biotechnology journal

    pub_type: 杂志文章

    doi:10.1016/j.csbj.2020.07.003

    authors: Magi A,Giangregorio T,Semeraro R,Carangelo G,Palombo F,Romeo G,Seri M,Pippucci T

    更新日期:2020-07-14 00:00:00

  • Protein electrostatics: From computational and structural analysis to discovery of functional fingerprints and biotechnological design.

    abstract::Computationally driven engineering of proteins aims to allow them to withstand an extended range of conditions and to mediate modified or novel functions. Therefore, it is crucial to the biotechnological industry, to biomedicine and to afford new challenges in environmental sciences, such as biocatalysis for green che...

    journal_title:Computational and structural biotechnology journal

    pub_type: 杂志文章,评审

    doi:10.1016/j.csbj.2020.06.029

    authors: Vascon F,Gasparotto M,Giacomello M,Cendron L,Bergantino E,Filippini F,Righetto I

    更新日期:2020-06-30 00:00:00

  • Assessment of vector-host-pathogen relationships using data mining and machine learning.

    abstract::Infectious diseases, including vector-borne diseases transmitted by arthropods, are a leading cause of morbidity and mortality worldwide. In the era of big data, addressing broad-scale, fundamental questions regarding the complex dynamics of these diseases will increasingly require the integration of diverse datasets ...

    journal_title:Computational and structural biotechnology journal

    pub_type: 杂志文章,评审

    doi:10.1016/j.csbj.2020.06.031

    authors: Agany DDM,Pietri JE,Gnimpieba EZ

    更新日期:2020-06-25 00:00:00

  • Bioinformatics approaches for deciphering the epitranscriptome: Recent progress and emerging topics.

    abstract::Post-transcriptional RNA modification occurs on all types of RNA and plays a vital role in regulating every aspect of RNA function. Thanks to the development of high-throughput sequencing technologies, transcriptome-wide profiling of RNA modifications has been made possible. With the accumulation of a large number of ...

    journal_title:Computational and structural biotechnology journal

    pub_type: 杂志文章,评审

    doi:10.1016/j.csbj.2020.06.010

    authors: Liu L,Song B,Ma J,Song Y,Zhang SY,Tang Y,Wu X,Wei Z,Chen K,Su J,Rong R,Lu Z,de Magalhães JP,Rigden DJ,Zhang L,Zhang SW,Huang Y,Lei X,Liu H,Meng J

    更新日期:2020-06-13 00:00:00

  • HiPR: High-throughput probabilistic RNA structure inference.

    abstract::Recent high-throughput structure-sensitive genome-wide sequencing-based assays have enabled large-scale studies of RNA structure, and robust transcriptome-wide computational prediction of individual RNA structures across RNA classes from these assays has potential to further improve the prediction accuracy. Here, we d...

    journal_title:Computational and structural biotechnology journal

    pub_type: 杂志文章

    doi:10.1016/j.csbj.2020.06.004

    authors: Kuksa PP,Li F,Kannan S,Gregory BD,Leung YY,Wang LS

    更新日期:2020-06-08 00:00:00

  • Constructing knowledge graphs and their biomedical applications.

    abstract::Knowledge graphs can support many biomedical applications. These graphs represent biomedical concepts and relationships in the form of nodes and edges. In this review, we discuss how these graphs are constructed and applied with a particular focus on how machine learning approaches are changing these processes. Biomed...

    journal_title:Computational and structural biotechnology journal

    pub_type: 杂志文章,评审

    doi:10.1016/j.csbj.2020.05.017

    authors: Nicholson DN,Greene CS

    更新日期:2020-06-02 00:00:00

  • Deep learning predicts microbial interactions from self-organized spatiotemporal patterns.

    abstract::Microbial communities organize into spatial patterns that are largely governed by interspecies interactions. This phenomenon is an important metric for understanding community functional dynamics, yet the use of spatial patterns for predicting microbial interactions is currently lacking. Here we propose supervised dee...

    journal_title:Computational and structural biotechnology journal

    pub_type: 杂志文章

    doi:10.1016/j.csbj.2020.05.023

    authors: Lee JY,Sadler NC,Egbert RG,Anderton CR,Hofmockel KS,Jansson JK,Song HS

    更新日期:2020-05-29 00:00:00

  • Rewired functional regulatory networks among miRNA isoforms (isomiRs) from let-7 and miR-10 gene families in cancer.

    abstract::Classical microRNA (miRNA) has been so far believed as a single sequence, but it indeed contains multiple miRNA isoforms (isomiR) with various sequences and expression patterns. It is not clear whether these diverse isomiRs have potential relationships and whether they contribute to miRNA:mRNA interactions. Here, we a...

    journal_title:Computational and structural biotechnology journal

    pub_type: 杂志文章

    doi:10.1016/j.csbj.2020.05.001

    authors: Liang T,Han L,Guo L

    更新日期:2020-05-13 00:00:00

  • Microvesicles from indoxyl sulfate-treated endothelial cells induce vascular calcification in vitro.

    abstract::Vascular calcification (VC), an unpredictable pathophysiological process and critical event in patients with cardiovascular diseases (CVDs), is the leading cause of morbi-mortality and disability in chronic kidney disease (CKD) patients worldwide. Currently, no diagnostic method is available for identifying patients a...

    journal_title:Computational and structural biotechnology journal

    pub_type: 杂志文章

    doi:10.1016/j.csbj.2020.04.006

    authors: Alique M,Bodega G,Corchete E,García-Menéndez E,de Sequera P,Luque R,Rodríguez-Padrón D,Marqués M,Portolés J,Carracedo J,Ramírez R

    更新日期:2020-04-09 00:00:00

  • CirRNAPL: A web server for the identification of circRNA based on extreme learning machine.

    abstract::Circular RNA (circRNA) plays an important role in the development of diseases, and it provides a novel idea for drug development. Accurate identification of circRNAs is important for a deeper understanding of their functions. In this study, we developed a new classifier, CirRNAPL, which extracts the features of nuclei...

    journal_title:Computational and structural biotechnology journal

    pub_type: 杂志文章

    doi:10.1016/j.csbj.2020.03.028

    authors: Niu M,Zhang J,Li Y,Wang C,Liu Z,Ding H,Zou Q,Ma Q

    更新日期:2020-04-02 00:00:00

  • Both intra and inter-domain interactions define the intrinsic dynamics and allosteric mechanism in DNMT1s.

    abstract::DNA methyltransferase 1 (DNMT1), a large multidomain enzyme, is believed to be involved in the passive transmission of genomic methylation patterns via methylation maintenance. Yet, the molecular mechanism of interaction networks underlying DNMT1 structures, dynamics, and its biological significance has yet to be full...

    journal_title:Computational and structural biotechnology journal

    pub_type: 杂志文章

    doi:10.1016/j.csbj.2020.03.016

    authors: Liang Z,Zhu Y,Long J,Ye F,Hu G

    更新日期:2020-03-23 00:00:00

  • Ethical issues related to research on genome editing in human embryos.

    abstract::Although the potential advantages of clinical germline genome editing (GGE) over currently available methods are limited, the implementation of GGE in the clinic has been proposed and discussed. Ethical issues related to such an application have been extensively debated, meanwhile, seemingly less attention has been pa...

    journal_title:Computational and structural biotechnology journal

    pub_type: 杂志文章,评审

    doi:10.1016/j.csbj.2020.03.014

    authors: Niemiec E,Howard HC

    更新日期:2020-03-21 00:00:00

  • PreMSIm: An R package for predicting microsatellite instability from the expression profiling of a gene panel in cancer.

    abstract::Microsatellite instability (MSI) is a genomic property of the cancers with defective DNA mismatch repair and is a useful marker for cancer diagnosis and treatment in diverse cancer types. In particular, MSI has been associated with the active immune checkpoint blockade therapy response in cancer. Most of computational...

    journal_title:Computational and structural biotechnology journal

    pub_type: 杂志文章

    doi:10.1016/j.csbj.2020.03.007

    authors: Li L,Feng Q,Wang X

    更新日期:2020-03-19 00:00:00

  • On fusion methods for knowledge discovery from multi-omics datasets.

    abstract::Recent years have witnessed the tendency of measuring a biological sample on multiple omics scales for a comprehensive understanding of how biological activities on varying levels are perturbed by genetic variants, environments, and their interactions. This new trend raises substantial challenges to data integration a...

    journal_title:Computational and structural biotechnology journal

    pub_type: 杂志文章,评审

    doi:10.1016/j.csbj.2020.02.011

    authors: Baldwin E,Han J,Luo W,Zhou J,An L,Liu J,Zhang HH,Li H

    更新日期:2020-03-05 00:00:00

  • Prediction of the miRNA interactome - Established methods and upcoming perspectives.

    abstract::MicroRNAs (miRNAs) are well-studied small noncoding RNAs involved in post-transcriptional gene regulation in a wide range of organisms, including mammals. Their function is mediated by base pairing with their target RNAs. Although many features required for miRNA-mediated repression have been described, the identifica...

    journal_title:Computational and structural biotechnology journal

    pub_type: 杂志文章,评审

    doi:10.1016/j.csbj.2020.02.019

    authors: Schäfer M,Ciaudo C

    更新日期:2020-03-05 00:00:00

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