Abstract:
:Biomedical research and clinical decision depend increasingly on scientific evidence realized by a number of authoritative databases, mostly public and continually enriched via peer scientific contributions. Given the dynamic nature of biomedical evidence data and their usage in the sensitive domain of biomedical science, it is important to ensure retrieved data integrity and non-repudiation. In this work, we present a blockchain-based notarization service that uses smart digital contracts to seal a biomedical database query and the respective results. The goal is to ensure that retrieved data cannot be modified after retrieval and that the database cannot validly deny that the particular data has been provided as a result of a specific query. Biomedical evidence data versioning is also supported. The feasibility of the proposed notarization approach is demonstrated using a real blockchain infrastructure and is tested on two different biomedical evidence databases: a publicly available medical risk factor reference repository and on the PubMed database of biomedical literature references and abstracts.
journal_name
Comput Struct Biotechnol Jjournal_title
Computational and structural biotechnology journalauthors
Kleinaki AS,Mytis-Gkometh P,Drosatos G,Efraimidis PS,Kaldoudi Edoi
10.1016/j.csbj.2018.08.002subject
Has Abstractpub_date
2018-08-17 00:00:00pages
288-297issn
2001-0370pii
S2001-0370(18)30040-0journal_volume
16pub_type
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journal_title:Computational and structural biotechnology journal
pub_type: 杂志文章,评审
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journal_title:Computational and structural biotechnology journal
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journal_title:Computational and structural biotechnology journal
pub_type: 杂志文章,评审
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journal_title:Computational and structural biotechnology journal
pub_type: 杂志文章,评审
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journal_title:Computational and structural biotechnology journal
pub_type: 杂志文章,评审
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journal_title:Computational and structural biotechnology journal
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journal_title:Computational and structural biotechnology journal
pub_type: 杂志文章
doi:10.1016/j.csbj.2020.02.007
更新日期:2020-02-20 00:00:00
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journal_title:Computational and structural biotechnology journal
pub_type: 杂志文章
doi:10.1016/j.csbj.2020.05.001
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journal_title:Computational and structural biotechnology journal
pub_type: 杂志文章,评审
doi:10.1016/j.csbj.2020.12.009
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journal_title:Computational and structural biotechnology journal
pub_type: 杂志文章
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journal_title:Computational and structural biotechnology journal
pub_type: 杂志文章,评审
doi:10.1016/j.csbj.2014.08.008
更新日期:2014-09-03 00:00:00
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journal_title:Computational and structural biotechnology journal
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journal_title:Computational and structural biotechnology journal
pub_type: 杂志文章
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journal_title:Computational and structural biotechnology journal
pub_type: 杂志文章,评审
doi:10.1016/j.csbj.2019.08.008
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doi:10.1016/j.csbj.2020.10.026
更新日期:2020-11-11 00:00:00
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journal_title:Computational and structural biotechnology journal
pub_type: 杂志文章
doi:10.1016/j.csbj.2018.10.008
更新日期:2018-10-18 00:00:00
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journal_title:Computational and structural biotechnology journal
pub_type: 杂志文章,评审
doi:10.5936/csbj.201209009
更新日期:2012-10-23 00:00:00
abstract:Motivation:With Next Generation Sequencing becoming more affordable every year, NGS technologies asserted themselves as the fastest and most reliable way to detect Single Nucleotide Variants (SNV) and Copy Number Variations (CNV) in cancer patients. These technologies can be used to sequence DNA at very high depths thu...
journal_title:Computational and structural biotechnology journal
pub_type: 杂志文章
doi:10.1016/j.csbj.2020.08.011
更新日期:2020-08-27 00:00:00
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journal_title:Computational and structural biotechnology journal
pub_type: 杂志文章
doi:10.1016/j.csbj.2014.07.002
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journal_title:Computational and structural biotechnology journal
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doi:10.1016/j.csbj.2020.12.042
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journal_title:Computational and structural biotechnology journal
pub_type: 杂志文章
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更新日期:2019-06-11 00:00:00
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journal_title:Computational and structural biotechnology journal
pub_type: 杂志文章,评审
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journal_title:Computational and structural biotechnology journal
pub_type: 杂志文章
doi:10.1016/j.csbj.2019.08.001
更新日期:2019-08-07 00:00:00
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journal_title:Computational and structural biotechnology journal
pub_type: 杂志文章,评审
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更新日期:2020-03-05 00:00:00
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journal_title:Computational and structural biotechnology journal
pub_type: 杂志文章,评审
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journal_title:Computational and structural biotechnology journal
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journal_title:Computational and structural biotechnology journal
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更新日期:2020-12-23 00:00:00
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journal_title:Computational and structural biotechnology journal
pub_type: 杂志文章,评审
doi:10.1016/j.csbj.2020.08.003
更新日期:2020-08-07 00:00:00