Abstract:
:Traditional Chinese Medicine (TCM) has a long history of widespread clinical applications, especially in East Asia, and is becoming frequently used in Western countries. However, owing to extreme complicacy in both chemical ingredients and mechanism of action, a deep understanding of TCM is still difficult. To accelerate the modernization and popularization of TCM, a single comprehensive database is required, containing a wealth of TCM-related information and equipped with complete analytical tools. Here we present YaTCM (Yet another Traditional Chinese Medicine database), a free web-based toolkit, which provides comprehensive TCM information and is furnished with analysis tools. YaTCM allows a user to (1) identify the potential ingredients that are crucial to TCM herbs through similarity search and substructure search, (2) investigate the mechanism of action for TCM or prescription through pathway analysis and network pharmacology analysis, (3) predict potential targets for TCM molecules by multi-voting chemical similarity ensemble approach, and (4) explore functionally similar herb pairs. All these functions can lead to one systematic network for visualization of TCM recipes, herbs, ingredients, definite or putative protein targets, pathways, and diseases. This web service would help in uncovering the mechanism of action of TCM, revealing the essence of TCM theory and then promoting the drug discovery process. YaTCM is freely available at http://cadd.pharmacy.nankai.edu.cn/yatcm/home.
journal_name
Comput Struct Biotechnol Jjournal_title
Computational and structural biotechnology journalauthors
Li B,Ma C,Zhao X,Hu Z,Du T,Xu X,Wang Z,Lin Jdoi
10.1016/j.csbj.2018.11.002subject
Has Abstractpub_date
2018-11-23 00:00:00pages
600-610issn
2001-0370pii
S2001-0370(18)30082-5journal_volume
16pub_type
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journal_title:Computational and structural biotechnology journal
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journal_title:Computational and structural biotechnology journal
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journal_title:Computational and structural biotechnology journal
pub_type: 杂志文章,评审
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更新日期:2012-10-23 00:00:00
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journal_title:Computational and structural biotechnology journal
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pub_type: 杂志文章,评审
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journal_title:Computational and structural biotechnology journal
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pub_type: 杂志文章,评审
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journal_title:Computational and structural biotechnology journal
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pub_type: 杂志文章,评审
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