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Recent progress in experimental and human disease-associated multi-species biofilms.

Abstract：

:Human bodies are colonized by trillions of microorganisms, which are often referred to as human microbiota and play important roles in human health. Next generation sequencing studies have established links between the genetic content of human microbiota and various human diseases. However, it remains largely unknown about the spatial organizations and interspecies interactions of individual species within the human microbiota. Bacterial cells tend to form surface-attached biofilms in many natural environments, which enable intercellular communications and interactions in a microbial ecosystem. In this review, we summarize the recent progresses on the experimental and human disease-associated multi-species biofilm studies. We hypothesize that engineering biofilm structures and interspecies interactions might provide a tool for manipulating the composition and function of human microbiota.

journal_name

Comput Struct Biotechnol J

journal_title

Computational and structural biotechnology journal

authors

Bai F,Cai Z,Yang L

doi

10.1016/j.csbj.2019.09.010

subject

Has Abstract

pub_date

2019-10-25 00:00:00

pages

1234-1244

issn

2001-0370

pii

S2001-0370(19)30244-2

journal_volume

17

pub_type

杂志文章,评审

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