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The ecogenomics of dsDNA bacteriophages in feces of stabled and feral horses.

Abstract：

:The viromes of the mammalian lower gut were shown to be heavily dominated by bacteriophages; however, only for humans were the composition and intervariability of the bacteriophage communities studied in depth. Here we present an ecogenomics survey of dsDNA bacteriophage diversity in the feces of horses (Equus caballus), comparing two groups of stabled horses, and a further group of feral horses that were isolated on an island. Our results indicate that the dsDNA viromes of the horse feces feature higher richness than in human viromes, with more even distribution of genotypes. No over-represented phage genotypes, such as CrAssphage-related viruses found in humans, were identified. Additionally, many bacteriophage genus-level clusters were found to be present in all three geographically isolated populations. The diversity of the horse intestinal bacteriophages is severely undersampled, and so consequently only a minor fraction of the phage contigs could be linked with the bacteriophage genomes. Our study indicates that bacteriophage ecological parameters in the intestinal ecosystems in horses and humans differ significantly, leading them to shape their corresponding viromes in different ways. Therefore, the diversity and structure of the intestinal virome in different animal species needs to be experimentally studied.

journal_name

Comput Struct Biotechnol J

journal_title

Computational and structural biotechnology journal

authors

Babenko VV,Millard A,Kulikov EE,Spasskaya NN,Letarova MA,Konanov DN,Belalov IS,Letarov AV

doi

10.1016/j.csbj.2020.10.036

subject

Has Abstract

pub_date

2020-11-10 00:00:00

pages

3457-3467

issn

2001-0370

pii

S2001-0370(20)30458-X

journal_volume

18

pub_type

杂志文章

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