当前位置： SCI文献检索 > Computational and Structural Biotechnology Journal期刊下所有文献 > Treatment According to Molecular Profiling in Relapsed/Refractory Cancer Patients: A Review Focusing on Latest Profiling Studies.

Treatment According to Molecular Profiling in Relapsed/Refractory Cancer Patients: A Review Focusing on Latest Profiling Studies.

Abstract：

:In this review we aim to summarize studies investigating the impact of a molecular profiling (MP)-guided treatment approach in heavily pretreated cancer patients. In summary, many independent single- and multicenter studies showed a significant benefit of MP-guided treatment regarding response rates and survival. However, in the only randomized trial conducted so far, no benefit of MP-guided targeted therapy was observed. Notably, various profiling approaches were conducted in the respective studies: some studies used a single analytic approach (i.e. next-generation sequencing), others applied multiple analytic methods to perform comprehensive molecular profiling. It seems that multiplatform profiling analyses, detected an increased number of druggable molecular targets or signaling pathway alterations and that a higher proportion of patients was treated according to the molecular cancer profile. Even though no randomized study has shown a benefit of molecular profiling so far, many studies indicate that MP-guided treatment can be beneficial in patients with relapsed and/or refractory cancer. Currently ongoing large randomized trials (i.e. NCI-MATCH, TAPUR) will add evidence to the role of profiling-guided cancer treatment.

journal_name

Comput Struct Biotechnol J

journal_title

Computational and structural biotechnology journal

authors

Zimmer K,Kocher F,Spizzo G,Salem M,Gastl G,Seeber A

doi

10.1016/j.csbj.2019.03.012

subject

Has Abstract

pub_date

2019-03-26 00:00:00

pages

447-453

issn

2001-0370

pii

S2001-0370(18)30308-8

journal_volume

17

pub_type

杂志文章,评审

相关文献

Computational and Structural Biotechnology Journal文献大全
  • A Blockchain-Based Notarization Service for Biomedical Knowledge Retrieval.

    abstract：:Biomedical research and clinical decision depend increasingly on scientific evidence realized by a number of authoritative databases, mostly public and continually enriched via peer scientific contributions. Given the dynamic nature of biomedical evidence data and their usage in the sensitive domain of biomedical scie...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.1016/j.csbj.2018.08.002

    authors： Kleinaki AS,Mytis-Gkometh P,Drosatos G,Efraimidis PS,Kaldoudi E

    更新日期：2018-08-17 00:00:00

  • Tribology of bio-inspired nanowrinkled films on ultrasoft substrates.

    abstract：:Biomimetic design of new materials uses nature as antetype, learning from billions of years of evolution. This work emphasizes the mechanical and tribological properties of skin, combining both hardness and wear resistance of its surface (the stratum corneum) with high elasticity of the bulk (epidermis, dermis, hypode...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.5936/csbj.201303002

    authors： Lackner JM,Waldhauser W,Major L,Teichert C,Hartmann P

    更新日期：2013-05-08 00:00:00

  • PreMSIm: An R package for predicting microsatellite instability from the expression profiling of a gene panel in cancer.

    abstract：:Microsatellite instability (MSI) is a genomic property of the cancers with defective DNA mismatch repair and is a useful marker for cancer diagnosis and treatment in diverse cancer types. In particular, MSI has been associated with the active immune checkpoint blockade therapy response in cancer. Most of computational...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.1016/j.csbj.2020.03.007

    authors： Li L,Feng Q,Wang X

    更新日期：2020-03-19 00:00:00

  • A molecular device: A DNA molecular lock driven by the nicking enzymes.

    abstract：:As people are placing more and more importance on information security, how to realize the protection of information has become a hotspot of current research. As a security device, DNA molecular locks have great potential to realize information protection at the molecular level. However, building a highly secure molec...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.1016/j.csbj.2020.08.004

    authors： Zhang X,Zhang Q,Liu Y,Wang B,Zhou S

    更新日期：2020-08-06 00:00:00

  • The era of big data: Genome-scale modelling meets machine learning.

    abstract：:With omics data being generated at an unprecedented rate, genome-scale modelling has become pivotal in its organisation and analysis. However, machine learning methods have been gaining ground in cases where knowledge is insufficient to represent the mechanisms underlying such data or as a means for data curation prio...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章,评审

    doi：10.1016/j.csbj.2020.10.011

    authors： Antonakoudis A,Barbosa R,Kotidis P,Kontoravdi C

    更新日期：2020-10-16 00:00:00

  • Causal inference for the effect of environmental chemicals on chronic kidney disease.

    abstract：:The impacts of environmental chemicals on the decline of kidney function have been suggested by a limited number of statistical and animal studies. Thus, those exposures may be modifiable risk factors for chronic kidney disease. Some of the chemicals, such as Perfluoroalkyl acid (PFA), are pervasive throughout our env...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.1016/j.csbj.2019.12.001

    authors： Zhao J,Hinton P,Chen J,Jiang J

    更新日期：2019-12-17 00:00:00

  • Asymmetric Spontaneous Intercalation of Lutein into a Phospholipid Bilayer, a Computational Study.

    abstract：:Lutein, a hydroxylated carotenoid, is a pigment synthesised by plants and bacteria. Animals are unable to synthesise lutein, nevertheless, it is present in animal tissues, where its only source is dietary intake. Both in plants and animals, carotenoids are associated mainly with membranes where they carry out importan...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.1016/j.csbj.2019.04.001

    authors： Makuch K,Markiewicz M,Pasenkiewicz-Gierula M

    更新日期：2019-04-06 00:00:00

  • Multi-population cohort meta-analysis of human intestinal microbiota in early life reveals the existence of infant community state types (ICSTs).

    abstract：:Appropriate development of the intestinal microbiota during infancy is known to be important for human health. In fact, aberrant alterations of the microbial composition during childhood may cause short- and/or long-term negative health effects. Many factors influence the initial assembly and subsequent progression of...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.1016/j.csbj.2020.08.028

    authors： Mancabelli L,Tarracchini C,Milani C,Lugli GA,Fontana F,Turroni F,van Sinderen D,Ventura M

    更新日期：2020-09-15 00:00:00

  • Virulence factor-related gut microbiota genes and immunoglobulin A levels as novel markers for machine learning-based classification of autism spectrum disorder.

    abstract：:Autism spectrum disorder (ASD) is a neurodevelopmental condition for which early identification and intervention is crucial for optimum prognosis. Our previous work showed gut Immunoglobulin A (IgA) to be significantly elevated in the gut lumen of children with ASD compared to typically developing (TD) children. Gut m...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.1016/j.csbj.2020.12.012

    authors： Wang M,Doenyas C,Wan J,Zeng S,Cai C,Zhou J,Liu Y,Yin Z,Zhou W

    更新日期：2020-12-29 00:00:00

  • Discovery of novel helix binding sites at protein-protein interfaces.

    abstract：:Protein-protein interactions (PPIs) play a key role in numerous biological processes. Many efforts have been undertaken to develop PPI modulators for therapeutic applications; however, to date, most of the peptide binders designed to target PPIs are derived from native binding helices or using the native helix binding...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.1016/j.csbj.2019.11.001

    authors： Yang W,Sun X,Zhang C,Lai L

    更新日期：2019-11-11 00:00:00

  • Deep learning predicts microbial interactions from self-organized spatiotemporal patterns.

    abstract：:Microbial communities organize into spatial patterns that are largely governed by interspecies interactions. This phenomenon is an important metric for understanding community functional dynamics, yet the use of spatial patterns for predicting microbial interactions is currently lacking. Here we propose supervised dee...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.1016/j.csbj.2020.05.023

    authors： Lee JY,Sadler NC,Egbert RG,Anderton CR,Hofmockel KS,Jansson JK,Song HS

    更新日期：2020-05-29 00:00:00

  • FangNet: Mining herb hidden knowledge from TCM clinical effective formulas using structure network algorithm.

    abstract：:The use of herbs to treat various human diseases has been recorded for thousands of years. In Asia's current medical system, numerous herbal formulas have been repeatedly verified to confirm their effectiveness in different periods, which is a great resource for drug innovation and discovery. Through the mining of the...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.1016/j.csbj.2020.11.036

    authors： Bu D,Xia Y,Zhang J,Cao W,Huo P,Wang Z,He Z,Ding L,Wu Y,Zhang S,Gao K,Yu H,Liu T,Ding X,Gu X,Zhao Y

    更新日期：2020-12-04 00:00:00

  • Learning distributed representations of RNA and protein sequences and its application for predicting lncRNA-protein interactions.

    abstract：:The long noncoding RNAs (lncRNAs) are ubiquitous in organisms and play crucial role in a variety of biological processes and complex diseases. Emerging evidences suggest that lncRNAs interact with corresponding proteins to perform their regulatory functions. Therefore, identifying interacting lncRNA-protein pairs is t...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.1016/j.csbj.2019.11.004

    authors： Yi HC,You ZH,Cheng L,Zhou X,Jiang TH,Li X,Wang YB

    更新日期：2019-11-30 00:00:00

  • Computational Enzyme Design: Advances, hurdles and possible ways forward.

    abstract：:This mini review addresses recent developments in computational enzyme design. Successful protocols as well as known issues and limitations are discussed from an energetic perspective. It will be argued that improved results can be obtained by including a dynamic treatment in the design protocol. Finally, a molecular ...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章,评审

    doi：10.5936/csbj.201209009

    authors： Linder M

    更新日期：2012-10-23 00:00:00

  • Computational biophysical characterization of the SARS-CoV-2 spike protein binding with the ACE2 receptor and implications for infectivity.

    abstract：:SARS-CoV-2 is a novel highly virulent pathogen which gains entry to human cells by binding with the cell surface receptor - angiotensin converting enzyme (ACE2). We computationally contrasted the binding interactions between human ACE2 and coronavirus spike protein receptor binding domain (RBD) of the 2002 epidemic-ca...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.1016/j.csbj.2020.09.019

    authors： Chowdhury R,Boorla VS,Maranas CD

    更新日期：2020-01-01 00:00:00

  • Dynamic exchange of two types of stator units in Bacillus subtilis flagellar motor in response to environmental changes.

    abstract：:Bacteria can migrate towards more suitable environments by rotating flagella that are under the control of sensory signal transduction networks. The bacterial flagellum is composed of the long helical filament functioning as a propeller, the flexible hook as a universal joint and the basal body as a rotary motor power...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章,评审

    doi：10.1016/j.csbj.2020.10.009

    authors： Terahara N,Namba K,Minamino T

    更新日期：2020-10-15 00:00:00

  • Characterization of ENU-induced Mutations in Red Blood Cell Structural Proteins.

    abstract：:Murine models with modified gene function as a result of N-ethyl-N-nitrosourea (ENU) mutagenesis have been used to study phenotypes resulting from genetic change. This study investigated genetic factors associated with red blood cell (RBC) physiology and structural integrity that may impact on blood component storage ...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.5936/csbj.201303012

    authors： Kildey K,Flower RL,Tran TV,Tunningley R,Harris J,Dean MM

    更新日期：2013-09-23 00:00:00

  • SNP2Structure: A Public and Versatile Resource for Mapping and Three-Dimensional Modeling of Missense SNPs on Human Protein Structures.

    abstract：:One of the long-standing challenges in biology is to understand how non-synonymous single nucleotide polymorphisms (nsSNPs) change protein structure and further affect their function. While it is impractical to solve all the mutated protein structures experimentally, it is quite feasible to model the mutated structure...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.1016/j.csbj.2015.09.002

    authors： Wang D,Song L,Singh V,Rao S,An L,Madhavan S

    更新日期：2015-09-30 00:00:00

  • Classification and substrate head-group specificity of membrane fatty acid desaturases.

    abstract：:Membrane fatty acid desaturases are a diverse superfamily of enzymes that catalyze the introduction of double bonds into fatty acids. They are essential in a range of metabolic processes, such as the production of omega-3 fatty acids. However, our structure-function understanding of this superfamily is still developin...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.1016/j.csbj.2016.08.003

    authors： Li D,Moorman R,Vanhercke T,Petrie J,Singh S,Jackson CJ

    更新日期：2016-09-12 00:00:00

  • Homology modeling in the time of collective and artificial intelligence.

    abstract：:Homology modeling is a method for building protein 3D structures using protein primary sequence and utilizing prior knowledge gained from structural similarities with other proteins. The homology modeling process is done in sequential steps where sequence/structure alignment is optimized, then a backbone is built and ...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章,评审

    doi：10.1016/j.csbj.2020.11.007

    authors： Hameduh T,Haddad Y,Adam V,Heger Z

    更新日期：2020-11-14 00:00:00

  • Immunopathology, host-virus genome interactions, and effective vaccine development in SARS-CoV-2.

    abstract：:Coronaviruses are a group of enveloped RNA viruses that are diversely found in humans and now declared a global pandemic by the World Health Organization in March 2020. The population's susceptibility to these highly pathogenic coronaviruses has contributed to large outbreaks, evolved into public health events, and ra...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章,评审

    doi：10.1016/j.csbj.2020.11.011

    authors： Singh DD,Han I,Choi EH,Yadav DK

    更新日期：2020-01-01 00:00:00

  • Managing children with brain tumors during the COVID-19 era: Don't stop the care!

    abstract：:The COVID-19 pandemic has substantially stressed health care systems globally, subsequently reducing cancer care services and delaying treatments. Pediatric populations infected by COVID-19 have shown mild clinical symptoms compared to adults, perhaps due to decreased susceptibility. Several scientific societies and g...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章,评审

    doi：10.1016/j.csbj.2021.01.005

    authors： Capozza MA,Triarico S,Attinà G,Romano A,Mastrangelo S,Maurizi P,Frassanito P,Bianchi F,Verdolotti T,Gessi M,Balducci M,Massimi L,Tamburrini G,Ruggiero A,Gemelli Pediatric Neuro-Oncology Tumor Board.

    更新日期：2021-01-12 00:00:00

  • An Artificial Neural Network Integrated Pipeline for Biomarker Discovery Using Alzheimer's Disease as a Case Study.

    abstract：:The field of machine learning has allowed researchers to generate and analyse vast amounts of data using a wide variety of methodologies. Artificial Neural Networks (ANN) are some of the most commonly used statistical models and have been successful in biomarker discovery studies in multiple disease types. This review...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章,评审

    doi：10.1016/j.csbj.2018.02.001

    authors： Zafeiris D,Rutella S,Ball GR

    更新日期：2018-02-21 00:00:00

  • In Silico Prediction of Large-Scale Microbial Production Performance: Constraints for Getting Proper Data-Driven Models.

    abstract：:Industrial bioreactors range from 10.000 to 700.000 L and characteristically show different zones of substrate availabilities, dissolved gas concentrations and pH values reflecting physical, technical and economic constraints of scale-up. Microbial producers are fluctuating inside the bioreactors thereby experiencing ...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章,评审

    doi：10.1016/j.csbj.2018.06.002

    authors： Zieringer J,Takors R

    更新日期：2018-07-06 00:00:00

  • A Review on Genomics APIs.

    abstract：:The constant improvement and falling prices of whole human genome Next Generation Sequencing (NGS) has resulted in rapid adoption of genomic information at both clinics and research institutions. Considered together, the complexity of genomics data, due to its large volume and diversity along with the need for genomic...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章,评审

    doi：10.1016/j.csbj.2015.10.004

    authors： Swaminathan R,Huang Y,Moosavinasab S,Buckley R,Bartlett CW,Lin SM

    更新日期：2015-10-31 00:00:00

  • Disease, Models, Variants and Altered Pathways-Journeying RGD Through the Magnifying Glass.

    abstract：:Understanding the pathogenesis of disease is instrumental in delineating its progression mechanisms and for envisioning ways to counteract it. In the process, animal models represent invaluable tools for identifying disease-related loci and their genetic components. Amongst them, the laboratory rat is used extensively...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.1016/j.csbj.2015.11.006

    authors： Petri V,Hayman GT,Tutaj M,Smith JR,Laulederkind S,Wang SJ,Nigam R,De Pons J,Shimoyama M,Dwinell MR

    更新日期：2015-11-26 00:00:00

  • Experimental and computational analysis of biased agonism on full-length and a C-terminally truncated adenosine A2A receptor.

    abstract：:Biased agonism, the ability of agonists to differentially activate downstream signaling pathways by stabilizing specific receptor conformations, is a key issue for G protein-coupled receptor (GPCR) signaling. The C-terminal domain might influence this functional selectivity of GPCRs as it engages G proteins, GPCR kina...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.1016/j.csbj.2020.09.028

    authors： Navarro G,Gonzalez A,Campanacci S,Rivas-Santisteban R,Reyes-Resina I,Casajuana-Martin N,Cordomí A,Pardo L,Franco R

    更新日期：2020-09-24 00:00:00

  • UMI-Gen: A UMI-based read simulator for variant calling evaluation in paired-end sequencing NGS libraries.

    abstract：Motivation:With Next Generation Sequencing becoming more affordable every year, NGS technologies asserted themselves as the fastest and most reliable way to detect Single Nucleotide Variants (SNV) and Copy Number Variations (CNV) in cancer patients. These technologies can be used to sequence DNA at very high depths thu...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.1016/j.csbj.2020.08.011

    authors： Sater V,Viailly PJ,Lecroq T,Ruminy P,Bérard C,Prieur-Gaston É,Jardin F

    更新日期：2020-08-27 00:00:00

  • Protein electrostatics: From computational and structural analysis to discovery of functional fingerprints and biotechnological design.

    abstract：:Computationally driven engineering of proteins aims to allow them to withstand an extended range of conditions and to mediate modified or novel functions. Therefore, it is crucial to the biotechnological industry, to biomedicine and to afford new challenges in environmental sciences, such as biocatalysis for green che...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章,评审

    doi：10.1016/j.csbj.2020.06.029

    authors： Vascon F,Gasparotto M,Giacomello M,Cendron L,Bergantino E,Filippini F,Righetto I

    更新日期：2020-06-30 00:00:00

  • Nasal microbiome research in ANCA-associated vasculitis: Strengths, limitations, and future directions.

    abstract：:The human nasal microbiome is characterized by biodiversity and undergoes changes during the span of life. In granulomatosis with polyangiitis (GPA), the persistent nasal colonization by Staphylococcus aureus (S. aureus) assessed by culture-based detection methods has been associated with increased relapse frequency. ...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章,评审

    doi：10.1016/j.csbj.2020.12.031

    authors： Kronbichler A,Harrison EM,Wagner J

    更新日期：2020-12-27 00:00:00