当前位置： SCI文献检索 > Computational and Structural Biotechnology Journal期刊下所有文献 > Dynamic exchange of two types of stator units in Bacillus subtilis flagellar motor in response to environmental changes.

Dynamic exchange of two types of stator units in Bacillus subtilis flagellar motor in response to environmental changes.

Abstract：

:Bacteria can migrate towards more suitable environments by rotating flagella that are under the control of sensory signal transduction networks. The bacterial flagellum is composed of the long helical filament functioning as a propeller, the flexible hook as a universal joint and the basal body as a rotary motor powered by ion motive force across the cell membrane. The flagellar motor consists of a rotor and multiple stator units, each of which couples the ion flow through its ion channel with force generation. The flagellar building blocks and motor proteins are highly conserved among bacterial species, but structural and functional diversity of flagella has also been revealed. It has been reported that the structure and function of the flagellar motor of a Gram-positive bacterium, Bacillus subtilis, differ from those of Escherichia coli and Salmonella. The flagellar motor of the B. subtilis BR151MA strain possesses two distinct types of stator complexes, H+-type MotAB and Na+-type MotPS, around the rotor. These two types of stator units dynamically assemble to and disassemble from the rotor in response to environmental changes such as viscosity and external Na+ concentrations. In this mini-review article, we describe our recent understanding of the structure and dynamics of the B. subtilis flagellar motor.

journal_name

Comput Struct Biotechnol J

journal_title

Computational and structural biotechnology journal

authors

Terahara N,Namba K,Minamino T

doi

10.1016/j.csbj.2020.10.009

subject

Has Abstract

pub_date

2020-10-15 00:00:00

pages

2897-2907

issn

2001-0370

pii

S2001-0370(20)30431-1

journal_volume

18

pub_type

杂志文章,评审

相关文献

Computational and Structural Biotechnology Journal文献大全
  • Multi-population cohort meta-analysis of human intestinal microbiota in early life reveals the existence of infant community state types (ICSTs).

    abstract：:Appropriate development of the intestinal microbiota during infancy is known to be important for human health. In fact, aberrant alterations of the microbial composition during childhood may cause short- and/or long-term negative health effects. Many factors influence the initial assembly and subsequent progression of...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.1016/j.csbj.2020.08.028

    authors： Mancabelli L,Tarracchini C,Milani C,Lugli GA,Fontana F,Turroni F,van Sinderen D,Ventura M

    更新日期：2020-09-15 00:00:00

  • The era of big data: Genome-scale modelling meets machine learning.

    abstract：:With omics data being generated at an unprecedented rate, genome-scale modelling has become pivotal in its organisation and analysis. However, machine learning methods have been gaining ground in cases where knowledge is insufficient to represent the mechanisms underlying such data or as a means for data curation prio...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章,评审

    doi：10.1016/j.csbj.2020.10.011

    authors： Antonakoudis A,Barbosa R,Kotidis P,Kontoravdi C

    更新日期：2020-10-16 00:00:00

  • Internal Transcribed Spacer 1 (ITS1) based sequence typing reveals phylogenetically distinct Ascaris population.

    abstract：:Taxonomic differentiation among morphologically identical Ascaris species is a debatable scientific issue in the context of Ascariasis epidemiology. To explain the disease epidemiology and also the taxonomic position of different Ascaris species, genome information of infecting strains from endemic areas throughout th...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.1016/j.csbj.2015.08.006

    authors： Das K,Chowdhury P,Ganguly S

    更新日期：2015-09-04 00:00:00

  • From plant genomes to protein families: computational tools.

    abstract：:The development of new high-throughput sequencing technologies has increased dramatically the number of successful genomic projects. Thus, draft genomic sequences of more than 60 plant species are currently available. Suitable bioinformatics tools are being developed to assemble, annotate and analyze the enormous numb...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章,评审

    doi：10.5936/csbj.201307001

    authors： Martinez M

    更新日期：2013-08-14 00:00:00

  • Structural insights into the mechanism of RNA recognition by the N-terminal RNA-binding domain of the SARS-CoV-2 nucleocapsid phosphoprotein.

    abstract：:The emergence of recent SARS-CoV-2 has become a global health issue. This single-stranded positive-sense RNA virus is continuously spreading with increasing morbidities and mortalities. The proteome of this virus contains four structural and sixteen nonstructural proteins that ensure the replication of the virus in th...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.1016/j.csbj.2020.08.006

    authors： Khan A,Tahir Khan M,Saleem S,Junaid M,Ali A,Shujait Ali S,Khan M,Wei DQ

    更新日期：2020-01-01 00:00:00

  • Engineering microbes for plant polyketide biosynthesis.

    abstract：:Polyketides are an important group of secondary metabolites, many of which have important industrial applications in the food and pharmaceutical industries. Polyketides are synthesized from one of three classes of enzymes differentiated by their biochemical features and product structure: type I, type II or type III p...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章,评审

    doi：10.5936/csbj.201210020

    authors： Lussier FX,Colatriano D,Wiltshire Z,Page JE,Martin VJ

    更新日期：2013-02-22 00:00:00

  • On fusion methods for knowledge discovery from multi-omics datasets.

    abstract：:Recent years have witnessed the tendency of measuring a biological sample on multiple omics scales for a comprehensive understanding of how biological activities on varying levels are perturbed by genetic variants, environments, and their interactions. This new trend raises substantial challenges to data integration a...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章,评审

    doi：10.1016/j.csbj.2020.02.011

    authors： Baldwin E,Han J,Luo W,Zhou J,An L,Liu J,Zhang HH,Li H

    更新日期：2020-03-05 00:00:00

  • Homology modeling in the time of collective and artificial intelligence.

    abstract：:Homology modeling is a method for building protein 3D structures using protein primary sequence and utilizing prior knowledge gained from structural similarities with other proteins. The homology modeling process is done in sequential steps where sequence/structure alignment is optimized, then a backbone is built and ...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章,评审

    doi：10.1016/j.csbj.2020.11.007

    authors： Hameduh T,Haddad Y,Adam V,Heger Z

    更新日期：2020-11-14 00:00:00

  • A metagenome-wide association study of gut microbiome and visceral fat accumulation.

    abstract：Purpose:Visceral fat is an independent risk factor for metabolic and cardiovascular disease. The study aimed to investigate the associations between gut microbiome and visceral fat. Methods:We recruited 32 obese adults and 30 healthy controls at baseline. Among the obese subjects, 14 subjects underwent laparoscopic sl...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.1016/j.csbj.2020.09.026

    authors： Nie X,Chen J,Ma X,Ni Y,Shen Y,Yu H,Panagiotou G,Bao Y

    更新日期：2020-09-20 00:00:00

  • Directional Switching Mechanism of the Bacterial Flagellar Motor.

    abstract：:Bacteria sense temporal changes in extracellular stimuli via sensory signal transducers and move by rotating flagella towards into a favorable environment for their survival. Each flagellum is a supramolecular motility machine consisting of a bi-directional rotary motor, a universal joint and a helical propeller. The ...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章,评审

    doi：10.1016/j.csbj.2019.07.020

    authors： Minamino T,Kinoshita M,Namba K

    更新日期：2019-07-31 00:00:00

  • Assessment of automated analyses of cell migration on flat and nanostructured surfaces.

    abstract：:Motility studies of cells often rely on computer software that analyzes time-lapse recorded movies and establishes cell trajectories fully automatically. This raises the question of reproducibility of results, since different programs could yield significantly different results of such automated analysis. The fact tha...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.5936/csbj.201207004

    authors： Grădinaru C,Lopacińska JM,Huth J,Kestler HA,Flyvbjerg H,Mølhave K

    更新日期：2012-11-21 00:00:00

  • Computational Enzyme Design: Advances, hurdles and possible ways forward.

    abstract：:This mini review addresses recent developments in computational enzyme design. Successful protocols as well as known issues and limitations are discussed from an energetic perspective. It will be argued that improved results can be obtained by including a dynamic treatment in the design protocol. Finally, a molecular ...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章,评审

    doi：10.5936/csbj.201209009

    authors： Linder M

    更新日期：2012-10-23 00:00:00

  • In Silico Prediction of Large-Scale Microbial Production Performance: Constraints for Getting Proper Data-Driven Models.

    abstract：:Industrial bioreactors range from 10.000 to 700.000 L and characteristically show different zones of substrate availabilities, dissolved gas concentrations and pH values reflecting physical, technical and economic constraints of scale-up. Microbial producers are fluctuating inside the bioreactors thereby experiencing ...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章,评审

    doi：10.1016/j.csbj.2018.06.002

    authors： Zieringer J,Takors R

    更新日期：2018-07-06 00:00:00

  • Computational biophysical characterization of the SARS-CoV-2 spike protein binding with the ACE2 receptor and implications for infectivity.

    abstract：:SARS-CoV-2 is a novel highly virulent pathogen which gains entry to human cells by binding with the cell surface receptor - angiotensin converting enzyme (ACE2). We computationally contrasted the binding interactions between human ACE2 and coronavirus spike protein receptor binding domain (RBD) of the 2002 epidemic-ca...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.1016/j.csbj.2020.09.019

    authors： Chowdhury R,Boorla VS,Maranas CD

    更新日期：2020-01-01 00:00:00

  • ASJA: A Program for Assembling Splice Junctions Analysis.

    abstract：:RNA splicing may generate different kinds of splice junctions, such as linear, back-splice and fusion junctions. Only a limited number of programs are available for detection and quantification of splice junctions. Here, we present Assembling Splice Junctions Analysis (ASJA), a software package that identifies and cha...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.1016/j.csbj.2019.08.001

    authors： Zhao J,Li Q,Li Y,He X,Zheng Q,Huang S

    更新日期：2019-08-07 00:00:00

  • PreMSIm: An R package for predicting microsatellite instability from the expression profiling of a gene panel in cancer.

    abstract：:Microsatellite instability (MSI) is a genomic property of the cancers with defective DNA mismatch repair and is a useful marker for cancer diagnosis and treatment in diverse cancer types. In particular, MSI has been associated with the active immune checkpoint blockade therapy response in cancer. Most of computational...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.1016/j.csbj.2020.03.007

    authors： Li L,Feng Q,Wang X

    更新日期：2020-03-19 00:00:00

  • Of mice and men: Dissecting the interaction between Listeria monocytogenes Internalin A and E-cadherin.

    abstract：:We report a study of the interaction between internalin A (inlA) and human or murine E-cadherin (Ecad). inlA is used by Listeria monocytogenes to internalize itself into host cell, but the bacterium is unable to invade murine cells, which has been attributed to the difference in sequence between hEcad and mEcad. Using...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.5936/csbj.201303022

    authors： Genheden S,Eriksson LA

    更新日期：2013-12-15 00:00:00

  • IKKα Promotes the Progression and Metastasis of Non-Small Cell Lung Cancer Independently of its Subcellular Localization.

    abstract：:Lung cancer is the leading worldwide cause of cancer mortality, however, neither curative treatments nor substantial prolonged survival has been achieved, highlighting the need for investigating new proteins responsible for its development and progression. IKKα is an essential protein for cell survival and differentia...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.1016/j.csbj.2019.02.003

    authors： Page A,Ortega A,Alameda JP,Navarro M,Paramio JM,Saiz-Pardo M,Almeida EI,Hernández P,Fernández-Aceñero MJ,García-Fernández RA,Casanova ML

    更新日期：2019-02-07 00:00:00

  • Learning distributed representations of RNA and protein sequences and its application for predicting lncRNA-protein interactions.

    abstract：:The long noncoding RNAs (lncRNAs) are ubiquitous in organisms and play crucial role in a variety of biological processes and complex diseases. Emerging evidences suggest that lncRNAs interact with corresponding proteins to perform their regulatory functions. Therefore, identifying interacting lncRNA-protein pairs is t...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.1016/j.csbj.2019.11.004

    authors： Yi HC,You ZH,Cheng L,Zhou X,Jiang TH,Li X,Wang YB

    更新日期：2019-11-30 00:00:00

  • Assessment of vector-host-pathogen relationships using data mining and machine learning.

    abstract：:Infectious diseases, including vector-borne diseases transmitted by arthropods, are a leading cause of morbidity and mortality worldwide. In the era of big data, addressing broad-scale, fundamental questions regarding the complex dynamics of these diseases will increasingly require the integration of diverse datasets ...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章,评审

    doi：10.1016/j.csbj.2020.06.031

    authors： Agany DDM,Pietri JE,Gnimpieba EZ

    更新日期：2020-06-25 00:00:00

  • Purinergic control of inflammation and thrombosis: Role of P2X1 receptors.

    abstract：:Inflammation shifts the hemostatic mechanisms in favor of thrombosis. Upon tissue damage or infection, a sudden increase of extracellular ATP occurs, that might contribute to the crosstalk between inflammation and thrombosis. On platelets, P2X1 receptors act to amplify platelet activation and aggregation induced by ot...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章,评审

    doi：10.1016/j.csbj.2014.11.008

    authors： Oury C,Lecut C,Hego A,Wéra O,Delierneux C

    更新日期：2014-11-28 00:00:00

  • Stage-specific control of stem cell niche architecture in the Drosophila testis by the posterior Hox gene Abd-B.

    abstract：:A fundamental question in biology is how complex structures are maintained after their initial specification. We address this question by reviewing the role of the Hox gene Abd-B in Drosophila testis organogenesis, which proceeds through embryonic, larval and pupal stages to reach maturation in adult stages. The data ...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章,评审

    doi：10.1016/j.csbj.2015.01.001

    authors： Papagiannouli F,Lohmann I

    更新日期：2015-01-21 00:00:00

  • Virulence factor-related gut microbiota genes and immunoglobulin A levels as novel markers for machine learning-based classification of autism spectrum disorder.

    abstract：:Autism spectrum disorder (ASD) is a neurodevelopmental condition for which early identification and intervention is crucial for optimum prognosis. Our previous work showed gut Immunoglobulin A (IgA) to be significantly elevated in the gut lumen of children with ASD compared to typically developing (TD) children. Gut m...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.1016/j.csbj.2020.12.012

    authors： Wang M,Doenyas C,Wan J,Zeng S,Cai C,Zhou J,Liu Y,Yin Z,Zhou W

    更新日期：2020-12-29 00:00:00

  • Treatment According to Molecular Profiling in Relapsed/Refractory Cancer Patients: A Review Focusing on Latest Profiling Studies.

    abstract：:In this review we aim to summarize studies investigating the impact of a molecular profiling (MP)-guided treatment approach in heavily pretreated cancer patients. In summary, many independent single- and multicenter studies showed a significant benefit of MP-guided treatment regarding response rates and survival. Howe...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章,评审

    doi：10.1016/j.csbj.2019.03.012

    authors： Zimmer K,Kocher F,Spizzo G,Salem M,Gastl G,Seeber A

    更新日期：2019-03-26 00:00:00

  • A bird's-eye view of deep learning in bioimage analysis.

    abstract：:Deep learning of artificial neural networks has become the de facto standard approach to solving data analysis problems in virtually all fields of science and engineering. Also in biology and medicine, deep learning technologies are fundamentally transforming how we acquire, process, analyze, and interpret data, with ...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章,评审

    doi：10.1016/j.csbj.2020.08.003

    authors： Meijering E

    更新日期：2020-08-07 00:00:00

  • An Artificial Neural Network Integrated Pipeline for Biomarker Discovery Using Alzheimer's Disease as a Case Study.

    abstract：:The field of machine learning has allowed researchers to generate and analyse vast amounts of data using a wide variety of methodologies. Artificial Neural Networks (ANN) are some of the most commonly used statistical models and have been successful in biomarker discovery studies in multiple disease types. This review...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章,评审

    doi：10.1016/j.csbj.2018.02.001

    authors： Zafeiris D,Rutella S,Ball GR

    更新日期：2018-02-21 00:00:00

  • FangNet: Mining herb hidden knowledge from TCM clinical effective formulas using structure network algorithm.

    abstract：:The use of herbs to treat various human diseases has been recorded for thousands of years. In Asia's current medical system, numerous herbal formulas have been repeatedly verified to confirm their effectiveness in different periods, which is a great resource for drug innovation and discovery. Through the mining of the...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.1016/j.csbj.2020.11.036

    authors： Bu D,Xia Y,Zhang J,Cao W,Huo P,Wang Z,He Z,Ding L,Wu Y,Zhang S,Gao K,Yu H,Liu T,Ding X,Gu X,Zhao Y

    更新日期：2020-12-04 00:00:00

  • Identity, Structure and Compositional Analysis of Aluminum Phosphate Adsorbed Pediatric Quadrivalent and Pentavalent Vaccines.

    abstract：Purpose:The goal of this study is to set an empirical baseline to map the structure-function relation of the antigens from the commercialized vaccine products. Methods:To study the structural changes of protein antigens after adsorption several analytical tools including DLS, FTIR, Fluorescence, LD, and SEM have been ...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.1016/j.csbj.2018.11.006

    authors： Kalbfleisch K,Deshmukh S,Mei C,Ore M,Williams W,Durowoju I,Duprez J,Morin S,Carpick B,Kirkitadze M

    更新日期：2018-11-29 00:00:00

  • The role of protein interaction networks in systems biomedicine.

    abstract：:The challenging task of studying and modeling complex dynamics of biological systems in order to describe various human diseases has gathered great interest in recent years. Major biological processes are mediated through protein interactions, hence there is a need to understand the chaotic network that forms these pr...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章,评审

    doi：10.1016/j.csbj.2014.08.008

    authors： Sevimoglu T,Arga KY

    更新日期：2014-09-03 00:00:00

  • Disease, Models, Variants and Altered Pathways-Journeying RGD Through the Magnifying Glass.

    abstract：:Understanding the pathogenesis of disease is instrumental in delineating its progression mechanisms and for envisioning ways to counteract it. In the process, animal models represent invaluable tools for identifying disease-related loci and their genetic components. Amongst them, the laboratory rat is used extensively...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.1016/j.csbj.2015.11.006

    authors： Petri V,Hayman GT,Tutaj M,Smith JR,Laulederkind S,Wang SJ,Nigam R,De Pons J,Shimoyama M,Dwinell MR

    更新日期：2015-11-26 00:00:00