当前位置： SCI文献检索 > Computational and Structural Biotechnology Journal期刊下所有文献 > Directional Switching Mechanism of the Bacterial Flagellar Motor.

Directional Switching Mechanism of the Bacterial Flagellar Motor.

Abstract：

:Bacteria sense temporal changes in extracellular stimuli via sensory signal transducers and move by rotating flagella towards into a favorable environment for their survival. Each flagellum is a supramolecular motility machine consisting of a bi-directional rotary motor, a universal joint and a helical propeller. The signal transducers transmit environmental signals to the flagellar motor through a cytoplasmic chemotactic signaling pathway. The flagellar motor is composed of a rotor and multiple stator units, each of which acts as a transmembrane proton channel to conduct protons and exert force on the rotor. FliG, FliM and FliN form the C ring on the cytoplasmic face of the basal body MS ring made of the transmembrane protein FliF and act as the rotor. The C ring also serves as a switching device that enables the motor to spin in both counterclockwise (CCW) and clockwise (CW) directions. The phosphorylated form of the chemotactic signaling protein CheY binds to FliM and FliN to induce conformational changes of the C ring responsible for switching the direction of flagellar motor rotation from CCW to CW. In this mini-review, we will describe current understanding of the switching mechanism of the bacterial flagellar motor.

journal_name

Comput Struct Biotechnol J

journal_title

Computational and structural biotechnology journal

authors

Minamino T,Kinoshita M,Namba K

doi

10.1016/j.csbj.2019.07.020

subject

Has Abstract

pub_date

2019-07-31 00:00:00

pages

1075-1081

issn

2001-0370

pii

S2001-0370(19)30233-8

journal_volume

17

pub_type

杂志文章,评审

相关文献

Computational and Structural Biotechnology Journal文献大全
  • From plant genomes to protein families: computational tools.

    abstract：:The development of new high-throughput sequencing technologies has increased dramatically the number of successful genomic projects. Thus, draft genomic sequences of more than 60 plant species are currently available. Suitable bioinformatics tools are being developed to assemble, annotate and analyze the enormous numb...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章,评审

    doi：10.5936/csbj.201307001

    authors： Martinez M

    更新日期：2013-08-14 00:00:00

  • AUDACITY: A comprehensive approach for the detection and classification of Runs of Homozygosity in medical and population genomics.

    abstract：:Runs of Homozygosity (RoHs) are popular among geneticists as the footprint of demographic processes, evolutionary forces and inbreeding in shaping our genome, and are known to confer risk of Mendelian and complex diseases. Notwithstanding growing interest in their study, there is unmet need for reliable and rapid meth...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.1016/j.csbj.2020.07.003

    authors： Magi A,Giangregorio T,Semeraro R,Carangelo G,Palombo F,Romeo G,Seri M,Pippucci T

    更新日期：2020-07-14 00:00:00

  • Virulence factor-related gut microbiota genes and immunoglobulin A levels as novel markers for machine learning-based classification of autism spectrum disorder.

    abstract：:Autism spectrum disorder (ASD) is a neurodevelopmental condition for which early identification and intervention is crucial for optimum prognosis. Our previous work showed gut Immunoglobulin A (IgA) to be significantly elevated in the gut lumen of children with ASD compared to typically developing (TD) children. Gut m...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.1016/j.csbj.2020.12.012

    authors： Wang M,Doenyas C,Wan J,Zeng S,Cai C,Zhou J,Liu Y,Yin Z,Zhou W

    更新日期：2020-12-29 00:00:00

  • A guide to the identification of metabolites in NMR-based metabonomics/metabolomics experiments.

    abstract：:Metabonomics/metabolomics is an important science for the understanding of biological systems and the prediction of their behaviour, through the profiling of metabolites. Two technologies are routinely used in order to analyse metabolite profiles in biological fluids: nuclear magnetic resonance (NMR) spectroscopy and ...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.1016/j.csbj.2016.02.005

    authors： Dona AC,Kyriakides M,Scott F,Shephard EA,Varshavi D,Veselkov K,Everett JR

    更新日期：2016-03-09 00:00:00

  • Immunopathology, host-virus genome interactions, and effective vaccine development in SARS-CoV-2.

    abstract：:Coronaviruses are a group of enveloped RNA viruses that are diversely found in humans and now declared a global pandemic by the World Health Organization in March 2020. The population's susceptibility to these highly pathogenic coronaviruses has contributed to large outbreaks, evolved into public health events, and ra...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章,评审

    doi：10.1016/j.csbj.2020.11.011

    authors： Singh DD,Han I,Choi EH,Yadav DK

    更新日期：2020-01-01 00:00:00

  • Quantitative comparison of ABC membrane protein type I exporter structures in a standardized way.

    abstract：:An increasing number of ABC membrane protein structures are determined by cryo-electron microscopy and X-ray crystallography, consequently identifying differences between their conformations has become an arising issue. Therefore, we propose to define standardized measures for ABC Type I exporter structure characteriz...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.1016/j.csbj.2018.10.008

    authors： Csizmadia G,Farkas B,Spagina Z,Tordai H,Hegedűs T

    更新日期：2018-10-18 00:00:00

  • A Review on Genomics APIs.

    abstract：:The constant improvement and falling prices of whole human genome Next Generation Sequencing (NGS) has resulted in rapid adoption of genomic information at both clinics and research institutions. Considered together, the complexity of genomics data, due to its large volume and diversity along with the need for genomic...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章,评审

    doi：10.1016/j.csbj.2015.10.004

    authors： Swaminathan R,Huang Y,Moosavinasab S,Buckley R,Bartlett CW,Lin SM

    更新日期：2015-10-31 00:00:00

  • Combining Ramachandran plot and molecular dynamics simulation for structural-based variant classification: Using TP53 variants as model.

    abstract：:The wide application of new DNA sequencing technologies is generating vast quantities of genetic variation data at unprecedented speed. Developing methodologies to decode the pathogenicity of the variants is imperatively demanding. We hypothesized that as deleterious variants may function through disturbing structural...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.1016/j.csbj.2020.11.041

    authors： Tam B,Sinha S,Wang SM

    更新日期：2020-12-02 00:00:00

  • The role of protein interaction networks in systems biomedicine.

    abstract：:The challenging task of studying and modeling complex dynamics of biological systems in order to describe various human diseases has gathered great interest in recent years. Major biological processes are mediated through protein interactions, hence there is a need to understand the chaotic network that forms these pr...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章,评审

    doi：10.1016/j.csbj.2014.08.008

    authors： Sevimoglu T,Arga KY

    更新日期：2014-09-03 00:00:00

  • Meta-analysis of Liver and Heart Transcriptomic Data for Functional Annotation Transfer in Mammalian Orthologs.

    abstract：:Functional annotation transfer across multi-gene family orthologs can lead to functional misannotations. We hypothesised that co-expression network will help predict functional orthologs amongst complex homologous gene families. To explore the use of transcriptomic data available in public domain to identify functiona...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.1016/j.csbj.2017.08.002

    authors： Reyes PFL,Michoel T,Joshi A,Devailly G

    更新日期：2017-08-26 00:00:00

  • Disease, Models, Variants and Altered Pathways-Journeying RGD Through the Magnifying Glass.

    abstract：:Understanding the pathogenesis of disease is instrumental in delineating its progression mechanisms and for envisioning ways to counteract it. In the process, animal models represent invaluable tools for identifying disease-related loci and their genetic components. Amongst them, the laboratory rat is used extensively...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.1016/j.csbj.2015.11.006

    authors： Petri V,Hayman GT,Tutaj M,Smith JR,Laulederkind S,Wang SJ,Nigam R,De Pons J,Shimoyama M,Dwinell MR

    更新日期：2015-11-26 00:00:00

  • IKKα Promotes the Progression and Metastasis of Non-Small Cell Lung Cancer Independently of its Subcellular Localization.

    abstract：:Lung cancer is the leading worldwide cause of cancer mortality, however, neither curative treatments nor substantial prolonged survival has been achieved, highlighting the need for investigating new proteins responsible for its development and progression. IKKα is an essential protein for cell survival and differentia...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.1016/j.csbj.2019.02.003

    authors： Page A,Ortega A,Alameda JP,Navarro M,Paramio JM,Saiz-Pardo M,Almeida EI,Hernández P,Fernández-Aceñero MJ,García-Fernández RA,Casanova ML

    更新日期：2019-02-07 00:00:00

  • Protein electrostatics: From computational and structural analysis to discovery of functional fingerprints and biotechnological design.

    abstract：:Computationally driven engineering of proteins aims to allow them to withstand an extended range of conditions and to mediate modified or novel functions. Therefore, it is crucial to the biotechnological industry, to biomedicine and to afford new challenges in environmental sciences, such as biocatalysis for green che...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章,评审

    doi：10.1016/j.csbj.2020.06.029

    authors： Vascon F,Gasparotto M,Giacomello M,Cendron L,Bergantino E,Filippini F,Righetto I

    更新日期：2020-06-30 00:00:00

  • On fusion methods for knowledge discovery from multi-omics datasets.

    abstract：:Recent years have witnessed the tendency of measuring a biological sample on multiple omics scales for a comprehensive understanding of how biological activities on varying levels are perturbed by genetic variants, environments, and their interactions. This new trend raises substantial challenges to data integration a...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章,评审

    doi：10.1016/j.csbj.2020.02.011

    authors： Baldwin E,Han J,Luo W,Zhou J,An L,Liu J,Zhang HH,Li H

    更新日期：2020-03-05 00:00:00

  • ASJA: A Program for Assembling Splice Junctions Analysis.

    abstract：:RNA splicing may generate different kinds of splice junctions, such as linear, back-splice and fusion junctions. Only a limited number of programs are available for detection and quantification of splice junctions. Here, we present Assembling Splice Junctions Analysis (ASJA), a software package that identifies and cha...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.1016/j.csbj.2019.08.001

    authors： Zhao J,Li Q,Li Y,He X,Zheng Q,Huang S

    更新日期：2019-08-07 00:00:00

  • Fungi.guru: Comparative genomic and transcriptomic resource for the fungi kingdom.

    abstract：:The fungi kingdom is composed of eukaryotic heterotrophs, which are responsible for balancing the ecosystem and play a major role as decomposers. They also produce a vast diversity of secondary metabolites, which have antibiotic or pharmacological properties. However, our lack of knowledge of gene function in fungi pr...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.1016/j.csbj.2020.11.019

    authors： Lim JJJ,Koh J,Moo JR,Villanueva EMF,Putri DA,Lim YS,Seetoh WS,Mulupuri S,Ng JWZ,Nguyen NLU,Reji R,Foo H,Zhao MX,Chan TL,Rodrigues EE,Kairon RS,Hee KM,Chee NC,Low AD,Chen ZHX,Lim SC,Lunardi V,Fong TC,Chua CX

    更新日期：2020-11-20 00:00:00

  • Microvesicles from indoxyl sulfate-treated endothelial cells induce vascular calcification in vitro.

    abstract：:Vascular calcification (VC), an unpredictable pathophysiological process and critical event in patients with cardiovascular diseases (CVDs), is the leading cause of morbi-mortality and disability in chronic kidney disease (CKD) patients worldwide. Currently, no diagnostic method is available for identifying patients a...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.1016/j.csbj.2020.04.006

    authors： Alique M,Bodega G,Corchete E,García-Menéndez E,de Sequera P,Luque R,Rodríguez-Padrón D,Marqués M,Portolés J,Carracedo J,Ramírez R

    更新日期：2020-04-09 00:00:00

  • Current computational methods for predicting protein interactions of natural products.

    abstract：:Natural products (NPs) are an indispensable source of drugs and they have a better coverage of the pharmacological space than synthetic compounds, owing to their high structural diversity. The prediction of their interaction profiles with druggable protein targets remains a major challenge in modern drug discovery. Ex...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章,评审

    doi：10.1016/j.csbj.2019.08.008

    authors： Moumbock AFA,Li J,Mishra P,Gao M,Günther S

    更新日期：2019-10-28 00:00:00

  • Of mice and men: Dissecting the interaction between Listeria monocytogenes Internalin A and E-cadherin.

    abstract：:We report a study of the interaction between internalin A (inlA) and human or murine E-cadherin (Ecad). inlA is used by Listeria monocytogenes to internalize itself into host cell, but the bacterium is unable to invade murine cells, which has been attributed to the difference in sequence between hEcad and mEcad. Using...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.5936/csbj.201303022

    authors： Genheden S,Eriksson LA

    更新日期：2013-12-15 00:00:00

  • Dissecting complex polyketide biosynthesis.

    abstract：:Numerous bioactive natural products are synthesised by modular polyketide synthases. These compounds can be made in high yield by native multienzyme assembly lines. However, formation of analogues by genetically engineered systems is often considerably less efficient. Biochemical studies on intact polyketide synthase ...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章,评审

    doi：10.5936/csbj.201210010

    authors： Caffrey P

    更新日期：2012-11-17 00:00:00

  • Dynamic exchange of two types of stator units in Bacillus subtilis flagellar motor in response to environmental changes.

    abstract：:Bacteria can migrate towards more suitable environments by rotating flagella that are under the control of sensory signal transduction networks. The bacterial flagellum is composed of the long helical filament functioning as a propeller, the flexible hook as a universal joint and the basal body as a rotary motor power...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章,评审

    doi：10.1016/j.csbj.2020.10.009

    authors： Terahara N,Namba K,Minamino T

    更新日期：2020-10-15 00:00:00

  • Classification and substrate head-group specificity of membrane fatty acid desaturases.

    abstract：:Membrane fatty acid desaturases are a diverse superfamily of enzymes that catalyze the introduction of double bonds into fatty acids. They are essential in a range of metabolic processes, such as the production of omega-3 fatty acids. However, our structure-function understanding of this superfamily is still developin...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.1016/j.csbj.2016.08.003

    authors： Li D,Moorman R,Vanhercke T,Petrie J,Singh S,Jackson CJ

    更新日期：2016-09-12 00:00:00

  • Experimental and computational analysis of biased agonism on full-length and a C-terminally truncated adenosine A2A receptor.

    abstract：:Biased agonism, the ability of agonists to differentially activate downstream signaling pathways by stabilizing specific receptor conformations, is a key issue for G protein-coupled receptor (GPCR) signaling. The C-terminal domain might influence this functional selectivity of GPCRs as it engages G proteins, GPCR kina...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.1016/j.csbj.2020.09.028

    authors： Navarro G,Gonzalez A,Campanacci S,Rivas-Santisteban R,Reyes-Resina I,Casajuana-Martin N,Cordomí A,Pardo L,Franco R

    更新日期：2020-09-24 00:00:00

  • Computational Enzyme Design: Advances, hurdles and possible ways forward.

    abstract：:This mini review addresses recent developments in computational enzyme design. Successful protocols as well as known issues and limitations are discussed from an energetic perspective. It will be argued that improved results can be obtained by including a dynamic treatment in the design protocol. Finally, a molecular ...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章,评审

    doi：10.5936/csbj.201209009

    authors： Linder M

    更新日期：2012-10-23 00:00:00

  • The impact of Gag non-cleavage site mutations on HIV-1 viral fitness from integrative modelling and simulations.

    abstract：:The high mutation rate in retroviruses is one of the leading causes of drug resistance. In human immunodeficiency virus type-1 (HIV-1), synergistic mutations in its protease and the protease substrate - the Group-specific antigen (Gag) polyprotein - work together to confer drug resistance against protease inhibitors a...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.1016/j.csbj.2020.12.022

    authors： Samsudin F,Gan SK,Bond PJ

    更新日期：2020-12-23 00:00:00

  • Computational drug repurposing for inflammatory bowel disease using genetic information.

    abstract：:As knowledge of the genetics behind inflammatory bowel disease (IBD) has continually improved, there has been a demand for methods that can use this data in a clinically significant way. Genome-wide association analyses for IBD have identified 232 risk genetic loci for the disorder. While identification of these risk ...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.1016/j.csbj.2019.01.001

    authors： Grenier L,Hu P

    更新日期：2019-01-07 00:00:00

  • Managing children with brain tumors during the COVID-19 era: Don't stop the care!

    abstract：:The COVID-19 pandemic has substantially stressed health care systems globally, subsequently reducing cancer care services and delaying treatments. Pediatric populations infected by COVID-19 have shown mild clinical symptoms compared to adults, perhaps due to decreased susceptibility. Several scientific societies and g...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章,评审

    doi：10.1016/j.csbj.2021.01.005

    authors： Capozza MA,Triarico S,Attinà G,Romano A,Mastrangelo S,Maurizi P,Frassanito P,Bianchi F,Verdolotti T,Gessi M,Balducci M,Massimi L,Tamburrini G,Ruggiero A,Gemelli Pediatric Neuro-Oncology Tumor Board.

    更新日期：2021-01-12 00:00:00

  • An Artificial Neural Network Integrated Pipeline for Biomarker Discovery Using Alzheimer's Disease as a Case Study.

    abstract：:The field of machine learning has allowed researchers to generate and analyse vast amounts of data using a wide variety of methodologies. Artificial Neural Networks (ANN) are some of the most commonly used statistical models and have been successful in biomarker discovery studies in multiple disease types. This review...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章,评审

    doi：10.1016/j.csbj.2018.02.001

    authors： Zafeiris D,Rutella S,Ball GR

    更新日期：2018-02-21 00:00:00

  • Characterization of ENU-induced Mutations in Red Blood Cell Structural Proteins.

    abstract：:Murine models with modified gene function as a result of N-ethyl-N-nitrosourea (ENU) mutagenesis have been used to study phenotypes resulting from genetic change. This study investigated genetic factors associated with red blood cell (RBC) physiology and structural integrity that may impact on blood component storage ...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章

    doi：10.5936/csbj.201303012

    authors： Kildey K,Flower RL,Tran TV,Tunningley R,Harris J,Dean MM

    更新日期：2013-09-23 00:00:00

  • Stage-specific control of stem cell niche architecture in the Drosophila testis by the posterior Hox gene Abd-B.

    abstract：:A fundamental question in biology is how complex structures are maintained after their initial specification. We address this question by reviewing the role of the Hox gene Abd-B in Drosophila testis organogenesis, which proceeds through embryonic, larval and pupal stages to reach maturation in adult stages. The data ...

    journal_title：Computational and structural biotechnology journal

    pub_type： 杂志文章,评审

    doi：10.1016/j.csbj.2015.01.001

    authors： Papagiannouli F,Lohmann I

    更新日期：2015-01-21 00:00:00