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A guide to the identification of metabolites in NMR-based metabonomics/metabolomics experiments.

Abstract：

:Metabonomics/metabolomics is an important science for the understanding of biological systems and the prediction of their behaviour, through the profiling of metabolites. Two technologies are routinely used in order to analyse metabolite profiles in biological fluids: nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS), the latter typically with hyphenation to a chromatography system such as liquid chromatography (LC), in a configuration known as LC-MS. With both NMR and MS-based detection technologies, the identification of the metabolites in the biological sample remains a significant obstacle and bottleneck. This article provides guidance on methods for metabolite identification in biological fluids using NMR spectroscopy, and is illustrated with examples from recent studies on mice.

journal_name

Comput Struct Biotechnol J

journal_title

Computational and structural biotechnology journal

authors

Dona AC,Kyriakides M,Scott F,Shephard EA,Varshavi D,Veselkov K,Everett JR

doi

10.1016/j.csbj.2016.02.005

subject

Has Abstract

pub_date

2016-03-09 00:00:00

pages

135-53

issn

2001-0370

pii

S2001-0370(15)30019-2

journal_volume

14

pub_type

杂志文章

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