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Fungi.guru: Comparative genomic and transcriptomic resource for the fungi kingdom.

Abstract：

:The fungi kingdom is composed of eukaryotic heterotrophs, which are responsible for balancing the ecosystem and play a major role as decomposers. They also produce a vast diversity of secondary metabolites, which have antibiotic or pharmacological properties. However, our lack of knowledge of gene function in fungi precludes us from tailoring them to our needs and tapping into their metabolic diversity. To help remedy this, we gathered genomic and gene expression data of 19 most widely-researched fungi to build an online tool, fungi.guru, which contains tools for cross-species identification of conserved pathways, functional gene modules, and gene families. We exemplify how our tool can elucidate the molecular function, biological process and cellular component of genes involved in various biological processes, by identifying a secondary metabolite pathway producing gliotoxin in Aspergillus fumigatus, the catabolic pathway of cellulose in Coprinopsis cinerea and the conserved DNA replication pathway in Fusarium graminearum and Pyricularia oryzae. The tool is available at www.fungi.guru.

journal_name

Comput Struct Biotechnol J

journal_title

Computational and structural biotechnology journal

authors

Lim JJJ,Koh J,Moo JR,Villanueva EMF,Putri DA,Lim YS,Seetoh WS,Mulupuri S,Ng JWZ,Nguyen NLU,Reji R,Foo H,Zhao MX,Chan TL,Rodrigues EE,Kairon RS,Hee KM,Chee NC,Low AD,Chen ZHX,Lim SC,Lunardi V,Fong TC,Chua CX

doi

10.1016/j.csbj.2020.11.019

subject

Has Abstract

pub_date

2020-11-20 00:00:00

pages

3788-3795

issn

2001-0370

pii

S2001-0370(20)30486-4

journal_volume

18

pub_type

杂志文章

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