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Zebrafish small molecule screens: Taking the phenotypic plunge.

Abstract：

:Target based chemical screens are a mainstay of modern drug discovery, but the effectiveness of this reductionist approach is being questioned in light of declines in pharmaceutical R & D efficiency. In recent years, phenotypic screens have gained increasing acceptance as a complementary/alternative approach to early drug discovery. We discuss the various model organisms used in phenotypic screens, with particular focus on zebrafish, which has emerged as a leading model of in vivo phenotypic screens. Additionally, we anticipate therapeutic opportunities, particularly in orphan disease space, in the context of rapid advances in human Mendelian genetics, electronic health record (EHR)-enabled genome-phenome associations, and genome editing.

journal_name

Comput Struct Biotechnol J

journal_title

Computational and structural biotechnology journal

authors

Williams CH,Hong CC

doi

10.1016/j.csbj.2016.09.001

subject

Has Abstract

pub_date

2016-09-18 00:00:00

pages

350-356

issn

2001-0370

pii

S2001-0370(16)30044-7

journal_volume

14

pub_type

杂志文章,评审

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