Comparative Performance of 99mTc-TRODAT-1 SPECT/CT and 18F-FDOPA PET/CT Imaging in Patients With Parkinson's Disease, Parkinson-Plus Syndrome, and Essential Tremor.

Abstract:

PURPOSE:The aim of this study was to assess the utility of presynaptic dopaminergic imaging using 99mTc-TRODAT-1 SPECT/CT and 18F-FDOPA PET/CT and compare their performance in Parkinson's disease (PD), Parkinson-plus syndrome (PPS), and essential tremor (ET). PATIENTS AND METHODS:A total of 103 patients (PD = 48, PPS = 19, and ET = 36) were enrolled prospectively. Hoehn and Yahr (H&Y) staging and MDS-UPDRS (Movement Disorder Society-Sponsored Revision of Unified Parkinson's Disease Rating Scale) were done for PD and PPS cases. All the patients underwent 99mTc-TRODAT-1 SPECT/CT and 18F-FDOPA PET/CT brain scan. The scans were analyzed visually and semiquantitatively. Average pixel count and SUVmean of the striatum were calculated in SPECT and PET images, respectively, to calculate the specific uptake ratio of striatum (SUR). Comparison of scan findings and SURs among different groups and correlation with clinical characteristics was done. RESULTS:Symmetrical comma-shaped uptake was seen in bilateral striatum in ET cases with mean SURs significantly higher than in cases of early PD (H&Y stage I and II, n = 37), PD and PPS both on SPECT and PET images (P ≤ 0.001). The mean SURs between PD and PPS showed no significant difference (SPECT, P = 0.17; PET, P = 0.61). Substantial agreement (weighted κ = 0.659) was found between 99mTc-TRODAT-1 and 18F-FDOPA for the detection of presynaptic dopaminergic dysfunction. Specific uptake ratio of striatum correlation between SPECT and PET was statistically significant (r = 0.67; P < 0.01). A negative but nonsignificant correlation was found between the SURs and H&Y staging/MDS-UPDRS. CONCLUSIONS:Both 99mTc-TRODAT-1 SPECT/CT and 18F-FDOPA PET/CT showed substantial agreement and proved to be potential imaging biomarker for the detection of dopaminergic dysfunction, thus assisting in differentiating early PD/PD and PPS from ET cases.

journal_name

Clin Nucl Med

authors

Sood A,Shukla J,Shree R,Vatsa R,Modi M,Mittal BR

doi

10.1097/RLU.0000000000003409

subject

Has Abstract

pub_date

2021-02-01 00:00:00

pages

95-102

issue

2

eissn

0363-9762

issn

1536-0229

pii

00003072-202102000-00001

journal_volume

46

pub_type

杂志文章
  • Atypical findings of discordant bone scan and radiographs in transient osteoporosis of the hip: case report and review of the literature.

    abstract::The authors report atypical findings of discordant bone scans and radiography seen in a patient with transient osteoporosis of the hip (TOH). Presented in the case of a 60-year-old man who had spontaneous onset of left hip pain which worsened for 2 months with weight-bearing on the affected side. Initial and follow-up...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1097/00003072-199803000-00006

    authors: Tan TX,Dardani M,Neal DJ,Mueller CF,Pozderac RV

    更新日期:1998-03-01 00:00:00

  • Radiologic-Pathologic Correlations of Fibrosarcomatous Dermatofibrosarcoma Protuberans With Various Histological Features on Enhanced MRI and PET/MRI.

    abstract::Dermatofibrosarcoma protuberans (DFSP) is a cutaneous tumor of intermediate-grade malignant potential, and it rarely shows dedifferentiation to high-grade fibrosarcoma, which is called "fibrosarcomatous DFSP." We present the enhanced MRI and PET/MRI findings and our comparison with pathological findings in a case of f...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000001099

    authors: Hakozaki M,Yamada H,Hasegawa O,Watanabe K,Konno S

    更新日期:2016-03-01 00:00:00

  • Laparoscopic versus conventional cholecystectomy. Use of biliary scintigraphy.

    abstract::Laparoscopic cholecystectomy has become a popular alternative to traditional open cholecystectomy for uncomplicated, acute cholecystitis. At some centers, laparoscopic cholecystectomy is already the more frequently performed procedure. The presence or suspicion of common bile duct (CBD) stones or obstruction may neces...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-199210000-00001

    authors: Nagle CE,Murphy J

    更新日期:1992-10-01 00:00:00

  • 68Ga-Labeled PSMA Uptake in Nonprostatic Malignancies: Has the Time Come to Remove "PS" From PSMA?

    abstract::PET/CT with Ga-labeled prostate-specific membrane antigen (PSMA) is increasingly recognized as the best imaging modality for disease staging and detection of recurrent prostate cancer. Despite its name, PSMA expression has been reported in a number of nonprostatic benign and malignant pathologies. Apparently, angioneo...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000002103

    authors: Malik D,Kumar R,Mittal BR,Singh H,Bhattacharya A,Singh SK

    更新日期:2018-07-01 00:00:00

  • F-18 FDG PET/CT as a crucial guide toward optimal treatment planning in a case of postirradiation sarcoma 10 years after primary bone lymphoma of the pelvis.

    abstract::Ten years after chemoradiation for primary lymphoma of the left pelvic bone, a 38-year-old man presented with a 4-month history of gradually increasing pain in his left upper leg and thigh. Initial radiographs and contrast-enhanced magnetic resonance imaging were consistent with recurrent lymphoma, infection, or posti...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0b013e318217561c

    authors: de Rooy JW,Hambrock T,Vriens D,Flucke UE,van der Geest IC,van de Luijtgaarden AC,Schreuder BW,de Geus-Oei LF

    更新日期:2011-07-01 00:00:00

  • Prostate-Specific Membrane Antigen-Avid Meningioma Detected in 68Ga-Prostate-Specific Membrane Antigen PET/CT.

    abstract::A 64-year-old man with recently diagnosed prostate adenocarcinoma with a total prostate-specific antigen level of 3.32 ng/mL and Gleason score 4 (3 + 4) was referred for Ga-prostate-specific membrane antigen PET/CT scan for pretreatment staging. Prostate-specific membrane antigen-avid lesion was noted in the right lob...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000003172

    authors: Gupta N,Verma R,Belho ES

    更新日期:2020-09-01 00:00:00

  • Scintigraphic detection of invasive cutaneous malignant melanoma with Tc-99m MIBI.

    abstract::Malignant melanoma is a relatively uncommon cancer of increasing incidence. The authors report on two cases of malignant melanoma lesions (primary and lymph node metastasis) imaged with Tc-99m MIBI. One patient revealed intense accumulation of the radiotracer in a primary skin lesion of the thorax, whereas the other p...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-199607000-00010

    authors: Alonso O,Martinez M,Lago G,Bazzano C,Saadoun A,Mut F,Delgado L,Espasandin J,Touya E

    更新日期:1996-07-01 00:00:00

  • Obscured Meckel's Diverticulum by the Urinary Bladder: The Value of Lateral View and Post Void Images.

    abstract::We describe a case of a 5-year-old boy with a history of intermittent melena underwent TcO4 scintigraphy. On dynamic images, no abnormal activity was noted. After voiding and also in the lateral view, the focus of activity was noted in the superior and anterior aspect of the urinary bladder, compatible with a Meckel's...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000003016

    authors: Pirayesh E

    更新日期:2020-06-01 00:00:00

  • 18F NaF brain metastasis uptake in a patient with melanoma.

    abstract::A 57-year-old man with a history of metastatic melanoma and sclerotic bone lesions seen on CT was referred for F NaF PET/CT evaluation of active skeletal metastases. While the bone lesions had no uptake and were therefore thought to represent sequela of previously treated disease, an unexpected area of F NaF uptake wa...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000000371

    authors: Jones RP,Iagaru A

    更新日期:2014-10-01 00:00:00

  • Tc-99m labeled leukocytes in imaging of patients with suspected acute abdominal inflammation.

    abstract::One hundred patients with suspected acute abdominal inflammation were imaged at 0.5, 2-3, 4-6, and 24 hours after the administration of Tc-99m HMPAO labeled autologous leukocytes. Scan findings were retrospectively compared with final diagnosis, serum C-reactive protein (CRP), and antibiotic treatment. Clinical findin...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-199009000-00001

    authors: Laitinen R,Tähtinen J,Lantto T,Vorne M

    更新日期:1990-09-01 00:00:00

  • Ventilation-perfusion scintigraphic correlation with multimodality imaging in a proven case of Swyer-James (Macleod's) syndrome.

    abstract::The scintigraphic findings in a rare case of a unilateral matched ventilation perfusion defect, Swyer-James (Macleod's) syndrome, are presented. A 40-year-old man underwent ventilation/perfusion imaging for acute onset of dyspnea. The scan showed markedly diminished ventilation, vascular flow, and perfusion unilateral...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-199702000-00009

    authors: Salmanzadeh A,Pomeranz SJ,Ramsingh PS

    更新日期:1997-02-01 00:00:00

  • Myocardial infarct imaging with 99mTc-pyrophosphate and 99mTc-methylene diphosphonate: lack of correlation.

    abstract::A prospective study of eight patients with recent transmural myocardial infarction was performed using 99mTc-Sn-pyrophosphate and 99mTc-Sn-methylene diphosphonate in each patient. All pyrophosphate scans were strongly positive whereas the diphosphonate scan was strongly positive in only one case. We conclude that 99mT...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-197903000-00001

    authors: Makler PT Jr,Lederman S,Charkes ND,Malmud LS,Warner H,Reilley JJ

    更新日期:1979-03-01 00:00:00

  • Pulmonary Perfusion Changes Following Single-Lung Transplantation.

    abstract::Following single-lung transplantation (SLT), there is significant redistribution of flow preferentially to the transplanted lung. Altered lung perfusion leads to unusual results when performing pulmonary scintigraphy, which could result in interpretation errors. We present pulmonary scintigraphy images from a 67-year-...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000001581

    authors: Tsai J,Rowe SP,Solnes LB,Salas Fragomeni RA

    更新日期:2017-05-01 00:00:00

  • 68Ga-PSMA-Ligand PET/CT Uptake in Anthracosilicosis.

    abstract::This interesting image illustrates a case of biopsy-proven pulmonary anthracosilicosis, a mixed dust pneumoconiosis, associated with Ga-PSMA-ligand uptake. Prostate-specific membrane antigen (PSMA) is an emerging imaging biomarker, with clinical application in evaluation of prostate cancer using Ga-PSMA-ligand PET/CT....

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000001782

    authors: McGuiness M,Sounness B

    更新日期:2017-10-01 00:00:00

  • Three-phase bone scintigraphy for imaging osteoradionecrosis of the jaw.

    abstract:UNLABELLED:This study evaluates the diagnostic utility of 3-phase bone scintigraphy for diagnosing osteoradionecrosis of the jaw (ORNJ). METHODS:Thirty-two consecutive patients with a history of radiation to the head and neck region (range, 62-70 Gy; mean, 68 Gy; median, 69 Gy) due to squamous cell cancer and suspecte...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000000296

    authors: Lapa C,Linz C,Bluemel C,Mottok A,Mueller-Richter U,Kuebler A,Schneider P,Czernin J,Buck AK,Herrmann K

    更新日期:2014-01-01 00:00:00

  • Amyloidosis in FDG-avid lymph nodes.

    abstract::Amyloidosis in lymph node that is FDG-avid is an unusual diagnosis. FDG PET/CT showed the presence of multifocal lymphadenopathy mainly axillary with a mesenteric mass. Surgical lymph node biopsy with histological examination confirmed the diagnosis of amyloidosis in a 64-year-old woman with an initial left axillary p...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0b013e31827a230f

    authors: Abdou E,Amre R,Hickeson M,Derbekyan V,Sebag M

    更新日期:2013-12-01 00:00:00

  • False-Positive 18F-FDG PET/CT Imaging: Dramatic "Flare Response" After Rituximab Administration.

    abstract::We report the case of a 45-year-old woman diagnosed with non-Hodgkin lymphoma. Six months after completion of R-CHOP, she relapsed, and 2 cycles of R-ESHAP were given, with a view to allograft transplant. One month later, F-FDG PET/CT revealed disease progression. Biopsy of lymph nodes showed reactive changes, without...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000001083

    authors: Skoura E,Ardeshna K,Halsey R,Wan S,Kayani I

    更新日期:2016-03-01 00:00:00

  • Tc-99m HMPAO diffuse pulmonary uptake demonstrated in cigarette smokers.

    abstract::Tc-99m HMPAO, a lipophilic radiotracer used as a brain SPECT imaging agent in the diagnosis of strokes and dementias, is normally localized in the brain and the heart and is excreted through the kidneys (50%) and the hepatobiliary system (14% to 30%). There is no pulmonary localization except in the lungs of smokers. ...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-199109000-00012

    authors: Shih WJ,Gruenwald F,Biersack HJ,Berger R,Brandenburg S,Coupal J,Ryo UY

    更新日期:1991-09-01 00:00:00

  • Uptake of Prostate-Specific Membrane Antigen-Targeted 18F-DCFPyL in Cerebral Radionecrosis: Implications for Diagnostic Imaging of High-Grade Gliomas.

    abstract::Recent PET imaging of glioblastoma multiforme and other high-grade gliomas using prostate-specific membrane antigen (PSMA)-targeted small-molecule radiotracers suggests a role for these agents in diagnostic imaging of recurrent/residual tumor and that PSMA-targeted endoradiotherapies may provide a new approach to ther...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000002280

    authors: Salas Fragomeni RA,Pienta KJ,Pomper MG,Gorin MA,Rowe SP

    更新日期:2018-11-01 00:00:00

  • Use of Tc-99m sestamibi infusion for detection of hibernating myocardium. A preliminary report.

    abstract::To evaluate whether a prolonged infusion of Tc-99m sestamibi allows for visualization of viable myocardium in areas of hypoperfused myocardium, 25 patients were prospectively studied. Each patient was imaged four times in two consecutive days in the following manner: day 1:1) immediately after injection of Tl-201 at r...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-199505000-00014

    authors: Miron SD,Finkelhor R,Bahler R,Sodee DB,Bellon EM

    更新日期:1995-05-01 00:00:00

  • Congenital hypothyroidism: diagnostic scintigraphic evaluation of an organification defect.

    abstract::Quantitative Tc-99m pertechnetate thyroid imaging was performed on a hypothyroid neonate. The image revealed markedly increased trapping in an enlarged, bilobed, eutopic gland. A perchlorate washout test using quantitative imaging with I-123 confirmed an organification problem. ...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-198806000-00006

    authors: Cone L,Oates E,Vazquez R

    更新日期:1988-06-01 00:00:00

  • Trochanteric bursitis. A case report of plain film, scintigraphic, and MRI correlation.

    abstract::A 43-year-old woman confined to bed and wheelchair due to multiple sclerosis (MS) presented with complaints of sharp, bilateral hip pain (left greater than right) that radiated to the thighs with point tenderness to trochanteric palpation. She had received several courses of high-dose intravenous corticosteroids for M...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:

    authors: Caruso FA,Toney MA

    更新日期:1994-05-01 00:00:00

  • A unique presentation of appendicitis: F-18 FDG PET/CT.

    abstract::A 27-year-old white man was diagnosed with a testicular, metastatic germ cell tumor. The patient was evaluated with F-18 fluorodeoxyglucose positron emission tomography and coregistered computed tomography (FDG PET/CT) as well as a contrast-enhanced CT (CECT) of the abdomen and pelvis. Serologic tests were performed. ...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/01.rlu.0000242723.61455.a8

    authors: Koff SG,Sterbis JR,Davison JM,Montilla-Soler JL

    更新日期:2006-11-01 00:00:00

  • MRI and FDG PET/CT findings of hepatic epithelioid hemangioendothelioma.

    abstract:PURPOSE:The aim of this study was to evaluate retrospectively magnetic resonance imaging (MRI) and (18)F fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) findings of hepatic epithelioid hemangioendothelioma (HEH). PATIENTS AND METHODS:MRI and FDG PET/CT findings were reviewed in 6 patie...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0b013e318266ceca

    authors: Dong A,Dong H,Wang Y,Gong J,Lu J,Zuo C

    更新日期:2013-02-01 00:00:00

  • 99mTc-MAG3 Renography of Intrathoracic Renal Ectopia.

    abstract::We report a case of a 49-year-old woman with a rare anomaly, intrathoracic renal ectopia. Her medical history includes a surgically corrected congenital diaphragmatic hernia, which can cause late presentations of diaphragmatic hernia in adult life. The Tc-MAG3 renogram demonstrated slower emptying of the dilated pelvi...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000002336

    authors: Ten Broek MRJ,Te Beek ET,Stuurman-Wieringa RE

    更新日期:2019-01-01 00:00:00

  • Quantitative lung scans for prediction of post-radiotherapy pulmonary function.

    abstract::Quantitative perfusion scans were used to predict the proportion of pulmonary function lost by inclusion of lung in radiotherapy fields. Nineteen patients receiving radiotherapy for carcinoma of the lung had pulmonary function evaluated by forced expiratory volume at 1 second (FEV1) prior to and following radiotherapy...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-198809000-00006

    authors: Moldofsky PJ,Rubenstein JH,Richter MP,Solin LJ,Gatenby RA,Broder GJ

    更新日期:1988-09-01 00:00:00

  • Focal splenic FDG uptake in a patient with Kala-Azar (visceral leishmaniasis).

    abstract::We present a woman with a history of Gaucher disease and secondary portal hypertension. She went to hospital for treatment of resistant fever without apparent cause. A conventional study of fever of unknown origin did not show any pathology. For this reason, she was referred to our department for a PET/CT, which did n...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000000369

    authors: Fuertes J,Garcia-Bennett JR,Iftimie S,Danús M,Abreu JA

    更新日期:2014-04-01 00:00:00

  • The diagnostic value of grading hyperperfusion and the rim sign in cholescintigraphy.

    abstract::Biliary scans of 84 hospitalized patients believed to likely have acute cholecystitis, including 55 scans that had a radionuclide angiography phase, were retrospectively evaluated to determine the frequency of the rim sign and hyperperfusion, and to test the hypothesis that more intense hyperperfusion or rim sign is a...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-199310000-00009

    authors: Bohdiewicz PJ

    更新日期:1993-10-01 00:00:00

  • Value and Efficacy of Sentinel Lymph Node Diagnostics in Patients With Penile Carcinoma With Nonpalpable Inguinal Lymph Nodes: Five-Year Follow-up.

    abstract:PURPOSE:Sentinel lymph node biopsy (SLNB) has been described as a minimally invasive method for lymph node staging in patients with a penile carcinoma and nonpalpable inguinal nodes in national and international guidelines of involved professional societies. However, this method is rarely used. The aim of this study wa...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000001268

    authors: Lützen U,Zuhayra M,Marx M,Zhao Y,Knüpfer S,Colberg C,Jünemann KP,Naumann CM

    更新日期:2016-08-01 00:00:00

  • Head and neck cancers: post-therapy changes in muscles with FDG PET-CT.

    abstract:BACKGROUND:FDG PET-CT plays a critical role in the management of head and neck cancer patients. After therapy, many patterns of altered physiologic FDG uptake have been recognized. In our institution, we noticed patterns of head and neck muscle uptake that were unique in the post-therapy scans of head and neck cancer p...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0b013e3181e05d94

    authors: Matthews R,Shrestha P,Franceschi D,Relan N,Kaloudis E

    更新日期:2010-07-01 00:00:00