Uptake of Prostate-Specific Membrane Antigen-Targeted 18F-DCFPyL in Cerebral Radionecrosis: Implications for Diagnostic Imaging of High-Grade Gliomas.

Abstract:

:Recent PET imaging of glioblastoma multiforme and other high-grade gliomas using prostate-specific membrane antigen (PSMA)-targeted small-molecule radiotracers suggests a role for these agents in diagnostic imaging of recurrent/residual tumor and that PSMA-targeted endoradiotherapies may provide a new approach to therapy for patients with these difficult-to-treat tumors. We present a case of cerebral radionecrosis demonstrating PSMA-targeted radiotracer uptake. Our findings may represent a potential pitfall and limitation to the diagnostic application of PSMA-targeted agents for high-grade gliomas.

journal_name

Clin Nucl Med

authors

Salas Fragomeni RA,Pienta KJ,Pomper MG,Gorin MA,Rowe SP

doi

10.1097/RLU.0000000000002280

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

e419-e421

issue

11

eissn

0363-9762

issn

1536-0229

journal_volume

43

pub_type

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