Abstract:
:To determine the potential of Tc-99m MIBI for detecting bone marrow malignancy, MIBI imaging of the femur was evaluated. There was no detectable MIBI activity in 125 of 141 (89%) control patients. Clearly demonstrated focal or tubular MIBI activity indicating intramedullary accumulation was demonstrated in 44 of 45 (98%) patients with proven marrow malignancy: 9 patients with multiple myeloma, 10 patients with malignant lymphoma, 11 patients with acute leukemia, 1 patient with chronic leukemia, and 14 patients with skeletal metastases. No abnormal MIBI activity was observed in the femur in 19 of 22 (86%) patients who had no evidence of malignant involvement in the femoral marrow, in 3 patients with solitary plasmacytomas of the spine, sternum or iliac bone, or in 16 patients with malignant lymphoma. In 12 of 24 patients with acute leukemia in complete remission, no abnormal MIBI accumulation was shown in the femur, but in 12 patients, abnormal accumulation indicating residual leukemic activity was demonstrated. MIBI imaging correlated extremely well with MRI studies; 26 of 28 patients with focal or tubular increased MIBI activity in the femur showed decreased signal on T1-weighted images and a high signal on short inversion recovery images, and 11 patients with no abnormal activity showed a high signal on T1 images. MIBI imaging of the femoral bone marrow may be a new modality for detecting marrow malignancy.
journal_name
Clin Nucl Medjournal_title
Clinical nuclear medicineauthors
Wakasugi S,Teshima H,Nakamura H,Hashizume T,Maeda T,Hiraoka A,Hasegawa Y,Masaoka Tdoi
10.1097/00003072-199810000-00004subject
Has Abstractpub_date
1998-10-01 00:00:00pages
664-71issue
10eissn
0363-9762issn
1536-0229journal_volume
23pub_type
杂志文章abstract::A case of non-Hodgkin's lymphoma of the abdomen studied by gallium SPECT imaging is reported. The tomographic slices accurately demonstrated the location of residual disease after chemotherapy in the region of the transverse mesocolon. Previous transmission CT had shown considerable persistent retroperitoneal lymphade...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198605000-00014
更新日期:1986-05-01 00:00:00
abstract::Being aware of the ideal nuclear properties of Tc-99m, our interest has been focused on the design of the (+5) oxidation state Tc-99m(V) dimercaptosuccinic acid (Tc(V)-DMSA) as a tumor-seeking agent. Tc-99m(V) DMSA holds a TcO4(3-) core and, like PO4(3-), has excellent characteristics for tumor uptake, but has a diffe...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198503000-00006
更新日期:1985-03-01 00:00:00
abstract:PURPOSE:This study documented the previously reported lower sensitivity of routine planar three-phase bone scintigraphy (BS) performed using a high-resolution parallel-hole collimator compared with MRI to diagnose nontraumatic avascular necrosis of the hip (AVN). METHODS:Six observers reviewed 143 bone scintigrams obt...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199907000-00003
更新日期:1999-07-01 00:00:00
abstract::Ga-prostate-specific membrane antigen (PSMA) ligand is a well-known tracer used in prostate cancer. Nevertheless, there are reports of unusual Ga-PSMA uptake in variety of benign lesions. We report a case of prostate cancer in which Ga-PSMA PET/CT revealed tracer avidity in the enhancing walls of cystic lesions in the...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001990
更新日期:2018-04-01 00:00:00
abstract:PURPOSE:The purpose of this study was to assess left ventricular (LV) function by gated SPECT in acute hypothyroidism. METHODS:Thirty-eight acute hypothyroid patients without any cardiac disease and 40 healthy controls underwent gated SPECT at rest. Fourteen patients had a second examination during thyroxine replaceme...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/01.rlu.0000252180.95540.64
更新日期:2007-02-01 00:00:00
abstract::A Tc-99m Technegas MAA-SPECT was performed on an 81-year-old woman to exclude pulmonary embolism. It showed hypoperfusion and practically absent ventilation of the entire left lung, suggesting a left-sided centrally localized airway obstruction or compression with secondary hypoxic vasoconstriction. Subsequent broncho...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e3181b06bea
更新日期:2009-09-01 00:00:00
abstract::Tc-99m hexamethylpropylene amineoxime (HMPAO) is a novel radiopharmaceutical demonstrated to be a sensitive indicator of abnormalities of cerebral perfusion. Most reports in the literature have evaluated patients with gross perfusion deficits, such as cerebrovascular accidents, and with dementia, where patterns of dif...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199103000-00007
更新日期:1991-03-01 00:00:00
abstract::The authors describe a patient with myelofibrosis who showed intense Ga-67 uptake in spite of being severely leukopenic and receiving large amounts of antibiotics. They conclude that false-negative results associated with leukopenia or intensive antibiotic treatment may not always be correct. ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199202000-00004
更新日期:1992-02-01 00:00:00
abstract:AIM:The purpose of this study was to conduct a systematic review of the published literature to assess the role (indications, advantages, and limitations) of SPECT/CT for the detection of sentinel lymph node (SLN) in breast cancer. METHODS:The authors searched PubMed for published literature in English addressing this...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章,meta分析
doi:10.1097/RLU.0b013e31829af8c0
更新日期:2014-05-01 00:00:00
abstract::The diagnosis of unilateral renal vein thrombosis was established in a 50-year-old woman. A functional evaluation, by means of Tc-99m DTPA, was performed almost immediately, and at intervals up to nearly eight months later. Functional return of the involved kidney could be documented by plotting the ratio of affected ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198311000-00007
更新日期:1983-11-01 00:00:00
abstract::A child with an asymptomatic mass in the lower right thorax was evaluated with sonography, intravenous urography, and radionuclide renography. High renal ectopia was only diagnosed with radionuclide renography. ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198309000-00004
更新日期:1983-09-01 00:00:00
abstract::Tc-99m hydroxymethylene disphosphonate administered for skeletal scintigraphy may be seen in the extraosseous tissues for various etiologies. This report presents similar abnormal lower extremity skeletal muscle uptake in 2 patients status postorthotopic liver transplant. Although the history and scintigraphic appeara...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-200411000-00004
更新日期:2004-11-01 00:00:00
abstract::A 27-year-old asymptomatic active duty military man underwent a screening chest x-ray secondary to a history of tuberculosis exposure. His chest x-ray showed no features of tuberculosis infection but unexpectedly revealed a markedly enlarged cardiac silhouette. Echocardiography demonstrated a large pericardial effusio...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000000944
更新日期:2015-11-01 00:00:00
abstract::Idiopathic fibrosis and malignant lymphoma were studied with positron emission tomography (PET) using 2-deoxy-2-[F-18]fluoro-D-glucose (F-18DG). Cases of retroperitoneal fibrosis and sclerosing peritonitis showed low F-18DG uptake with the mass/muscle radioactivity (M/M) ratio 2.0 and 1.9, respectively. A case of para...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199205000-00002
更新日期:1992-05-01 00:00:00
abstract::Lower neck uptake in bone scan is hard to interpret because of superposition of several structures. Single photon emission computerized tomography can be beneficial, as illustrated in this patient with a laryngeal tumor. ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198312000-00012
更新日期:1983-12-01 00:00:00
abstract::Esthesioneuroblastoma is a rare neoplasm arising from the neural crest cells of olfactory epithelium mostly in the nasal vault. We describe the Ga DOTANOC PET/CT findings of a 44-year-old woman who was operated for right nasal mass diagnosed as paraganglioma in the past and then develop a mass in the right nasal cavit...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000002644
更新日期:2019-08-01 00:00:00
abstract::The patient was a 57-year-old man with lung cancer. He was referred to nuclear medicine department for the evaluation of bone metastases. Bone scintigraphy was performed with 99mTc-labeled HDP. An abnormal photopenic area around the heart was seen on blood pool images. Delayed image of the thorax was normal. Chest x-r...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e3182708574
更新日期:2013-01-01 00:00:00
abstract::Magnetic resonance imaging (MRI) was compared with radionuclide scintigraphy (RNS) in 16 patients with renal transplants undergoing renal failure to determine which modality could best discriminate between rejection, acute tubular necrosis (ATN), and cyclosporin nephrotoxicity (CN). Although all rejecting transplants ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198804000-00005
更新日期:1988-04-01 00:00:00
abstract::A 9-year-old girl had a 6-month history of left hip pain. Radiographs of the left hip showed a metaphyseal osteolytic lesion with sclerotic borders in the femoral neck. Tc-99m MDP bone imaging and a Ga-67 scan showed focal areas of increased activity in the left femoral neck. These areas of increased uptake correspond...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199510000-00013
更新日期:1995-10-01 00:00:00
abstract::Radionuclide scintigraphy is a safe and accurate means of detecting postoperative urologic complications in renal transplant recipients. Early identification of urinary leakage coupled with aggressive intervention significantly reduces the associated morbidity and mortality. Perivesical extravasate may be difficult to...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198402000-00009
更新日期:1984-02-01 00:00:00
abstract:PURPOSE:To compare the accuracy of three camera-assisted methods for the measurement of Tc-99m mercaptoacetyltriglycine (MAG3) clearance. MATERIALS AND METHODS:MAG3 renal scintigraphy was performed in 21 adults with different degrees of renal function. Posterior views were obtained that included the heart and the kidn...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-200109000-00001
更新日期:2001-09-01 00:00:00
abstract::C-methionine (MET) positron emission tomography (PET) is more sensitive than F-fluorodeoxyglucose (FDG)-PET for detecting myeloma lesion. Many clinical studies support this evidence mainly for multiple myeloma cases of IgG or IgA subtypes. However, this is not confirmed for low monoclonal protein-producing myelomas, s...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001821
更新日期:2017-11-01 00:00:00
abstract::We describe a unique case of an occult esophageal cancer patient without any significant symptomatology, which initially presented with a subcutaneous metastasis in the thigh. Eventually, FDG PET-CT unmasked the primary tumor of unknown origin. ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e31818bf199
更新日期:2008-12-01 00:00:00
abstract:AIM:Adrenal metastasis in renal cell carcinoma (RCC) is uncommon. The present study was aimed to evaluate the role of fluoro-deoxy-glucose positron emission tomography (FDG PET)/computed tomography (CT) in the detection of adrenal metastasis in patients with RCC. MATERIALS AND METHODS:A total of 9 FDG PET/CT scans wer...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e3182175435
更新日期:2011-07-01 00:00:00
abstract::Bone scintigraphy is sensitive for detecting bone metastases in patients with malignancies. However, it is often difficult to differentiate bone metastases from other nonmalignant lesions. We encountered a patient with a history of breast cancer who showed substantial elevation of tumor markers 4 years after surgery. ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/01.rlu.0000170058.73956.82
更新日期:2005-08-01 00:00:00
abstract::Metastatic pulmonary calcification (MPC) characterized by diffuse calcium deposition in the lungs is known to occur in patients with chronic renal failure. However, MPC with pulmonary artery calcification is uncommon and has only been detected in a few patients with severe disorders. A 48-year-old man with chronic ren...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/01.rlu.0000159672.35328.13
更新日期:2005-05-01 00:00:00
abstract::Three cases involving renal scans that showed both severe photopenia and also increase in uptake in a rim surrounding the renal graft are presented. As previously mentioned in the literature, the bad prognostic import of photopenia is confirmed. The increased rim of activity has been rarely mentioned in the literature...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198508000-00012
更新日期:1985-08-01 00:00:00
abstract:PURPOSE:Insulinomas are predominantly benign neuroendocrine tumors originating from beta cells within the islets of Langerhans of the endocrine pancreas. Because surgical resection represents the only curative therapy option, exact tumor localization and discrimination of insulinomas from focal or diffuse manifestation...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000003093
更新日期:2020-07-01 00:00:00
abstract::Quantitative Tc-99m pertechnetate thyroid imaging was performed on a hypothyroid neonate. The image revealed markedly increased trapping in an enlarged, bilobed, eutopic gland. A perchlorate washout test using quantitative imaging with I-123 confirmed an organification problem. ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198806000-00006
更新日期:1988-06-01 00:00:00
abstract::Myocardial perfusion imaging with Tc-99m carbomethoxyisopropylisonitrile (CPI) was compared with Tl-201 imaging in 22 patients who were assessed for coronary artery disease. There was agreement between Tc-99m CPI and Tl-201 imaging for detecting segmental myocardial ischemia and fixed defects in 185/198 (93%) of left ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198709000-00001
更新日期:1987-09-01 00:00:00