Tc-99m mercaptoacetyltriglycine clearance: comparison of camera-assisted methods.

Abstract:

PURPOSE:To compare the accuracy of three camera-assisted methods for the measurement of Tc-99m mercaptoacetyltriglycine (MAG3) clearance. MATERIALS AND METHODS:MAG3 renal scintigraphy was performed in 21 adults with different degrees of renal function. Posterior views were obtained that included the heart and the kidneys in the camera field of view. The syringe for injection was imaged before and after injection. Blood samples were drawn 24 and 43 minutes after injection and plasma radioactivity was measured. Three camera-assisted techniques to measure MAG3 clearance were tested: 1) Biexponential fitting of the left ventricular curve, normalized to plasma activity at 24 minutes; 2) calculation of clearance by relating the integral of the plasma curve (normalized to plasma activity) to the kidney activity using the Rutland-Patlak space method; and 3) a regression equation measuring clearance from the percentage of the injected dose accumulating in the kidneys during the 1- to 2.5-minute period. The camera-assisted clearances were compared with the single-sample MAG3 clearances calculated using the Russell equation. Linear regression analysis was used to measure the correlation between the camera-based methods and the single-sample techniques. RESULTS:Correlation with r > 0.900 was found for all three techniques. The difference in correlation coefficients between the three methods was not significant; however, the regression line of method 3 was significantly closer to the line of identity (P = 0.005). CONCLUSION:Method 3 most closely fits the line of identity and is probably the most practical because no blood sample is needed.

journal_name

Clin Nucl Med

authors

Bocher M,Shrem Y,Tappiser A,Klein M,Schechter D,Taylor A Jr,Chisin R

doi

10.1097/00003072-200109000-00001

keywords:

subject

Has Abstract

pub_date

2001-09-01 00:00:00

pages

745-50

issue

9

eissn

0363-9762

issn

1536-0229

journal_volume

26

pub_type

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