Detection of protein bound vitamin B12 malabsorption. A case report and review of the literature.

Abstract:

:The Schilling test is used to identify the cause of vitamin B12 malabsorption in patients with low serum vitamin B12 levels. The initial step required for vitamin B12 absorption is a process of separation from the protein complexes of food. The crystalline Co-57 vitamin B12 used in the Schilling test does not reproduce this physiologic process. Thus, a crystalline stage I Schilling test may be normal even in the face of cobalamin malabsorption. An adjunctive stage I Schilling test using Co-57 vitamin B12 bound to protein has been developed. The authors describe a patient with protein-bound vitamin B12 malabsorption whose crystalline Co-57 vitamin B12 stage I Schilling test was normal. A subsequent stage I Schilling test using Co-57 vitamin B12 bound to chicken serum revealed significant cobalamin malabsorption. A review of the history and literature of this diagnostic test using protein bound vitamin B12 is also presented.

journal_name

Clin Nucl Med

authors

Lucas MH,Elgazzar AH

doi

10.1097/00003072-199411000-00015

subject

Has Abstract

pub_date

1994-11-01 00:00:00

pages

1001-3

issue

11

eissn

0363-9762

issn

1536-0229

journal_volume

19

pub_type

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