A comparison of the tumor-seeking agent Tc-99m(V) dimercaptosuccinic acid and the renal imaging agent Tc-99m dimercaptosuccinic acid in humans.

Abstract:

:Being aware of the ideal nuclear properties of Tc-99m, our interest has been focused on the design of the (+5) oxidation state Tc-99m(V) dimercaptosuccinic acid (Tc(V)-DMSA) as a tumor-seeking agent. Tc-99m(V) DMSA holds a TcO4(3-) core and, like PO4(3-), has excellent characteristics for tumor uptake, but has a different distribution than the well-known renal scanning agent, Tc-99m DMSA. The differences in chemical behavior of Tc-99m(V) DMSA and Tc-99m DMSA are discussed. Three cases in which neoplasms were studies with Tc-99m(V) DMSA and Tc-99m DMSA are presented. Tc-99m DMSA and Tc-99m(V) DMSA, having a common ligand and tracer but, with the metal ion core in a different oxidation state, the uptake characteristics are altered markedly.

journal_name

Clin Nucl Med

authors

Ohta H,Ishii M,Yoshizumi M,Endo K,Sakahara H,Nakajima T,Yomoda I,Masuda H,Horiuchi K,Hata N

doi

10.1097/00003072-198503000-00006

subject

Has Abstract,Author List Incomplete

pub_date

1985-03-01 00:00:00

pages

167-70

issue

3

eissn

0363-9762

issn

1536-0229

journal_volume

10

pub_type

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