Enhanced Application of 18F-FDG PET/CT in Bladder Cancer by Adding Early Dynamic Acquisition to a Standard Delayed PET Protocol.

Abstract:

PURPOSE:We investigated the value of early dynamic (ED) PET for the detection and characterization of bladder cancer. METHODS:Fifty-two bladder cancer patients were prospectively enrolled. The study protocol was composed of ED, whole-body (WB, 60 minutes after injection), and additional delayed (AD, 120 minutes after injection) PET acquisition. Early dynamic PET was acquired for 10 minutes and reconstructed as 5 frames at 2-minute intervals. A focal radiotracer accumulation confined to the bladder wall was considered as PET positive and referred for further quantitative measurement. SUVmax on ED (SUVmax, SUVmax, SUVmax, SUVmax, and SUVmax for 5 frames), WB (SUVmax), and AD PET (SUVmax) were measured. PET results were correlated with bladder cancer pathology variables. RESULTS:The sensitivities of ED, WB, and AD PET for bladder cancer were 84.6%, 57.7%, and 61.2%, respectively. The sensitivity of ED PET was significantly higher than that of WB (P = 0.002) and AD PET (P = 0.008). On ED PET, SUVmax was significantly correlated with muscle invasiveness, histological grade, and pathological tumor size (P = 0.018, P = 0.030, and P = 0.030). On WB and AD PET, only pathological tumor size showed significant positive correlation with SUVmax and SUVmax (P = 0.043 and P = 0.007). CONCLUSIONS:Early dynamic PET can help to detect and characterize bladder cancer.

journal_name

Clin Nucl Med

authors

Yoon HJ,Yoo J,Kim Y,Lee DH,Kim BS

doi

10.1097/RLU.0000000000001780

subject

Has Abstract

pub_date

2017-10-01 00:00:00

pages

749-755

issue

10

eissn

0363-9762

issn

1536-0229

journal_volume

42

pub_type

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