Abstract:
:Alpha-aminoisobutyric acid (AIB), a synthetic, nonmetabolized amino acid which is rapidly transported into viable cells by the A-type or alanine-preferring amino acid transport system, has been labeled with the short-lived, positron-emitting radionuclide carbon-11. Carbon-11 labeled AIB is currently being evaluated as a tumor imaging agent for in vivo amino acid transport studies in patients with cancer. In this study, C-11 AIB was used to image two patients with malignant fibrous histiocytoma (MFH), a pleomorphic sarcoma. Following intravenous administration of C-11 AIB, tumors in the distal femur of one patient and in the anterior chest wall of another patient were well visualized using high energy gamma scintigraphy. Since therapy may alter the accumulation of amino acids in tumor tissue, studies using C-11 AIB in patients with MFH before and after chemotherapy are in progress.
journal_name
Clin Nucl Medjournal_title
Clinical nuclear medicineauthors
Schmall B,Conti PS,Bigler RE,Zanzonico PB,Reiman RE,Benua RS,Yeh SD,Dahl JR,Lee R,Laughlin JSdoi
10.1097/00003072-198701000-00005subject
Has Abstractpub_date
1987-01-01 00:00:00pages
22-6issue
1eissn
0363-9762issn
1536-0229journal_volume
12pub_type
杂志文章abstract:PURPOSE:Primary hyperparathyroidism is a disease of uncertain etiology that results from hypersecretion of parathyroid hormone (PTH) by the parathyroid gland. In most institutions, the preferred imaging protocol utilizes a dual-phase technique with Tc-99m sestamibi which is reported to be more sensitive than earlier pr...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199804000-00003
更新日期:1998-04-01 00:00:00
abstract::A prospective study of eight patients with recent transmural myocardial infarction was performed using 99mTc-Sn-pyrophosphate and 99mTc-Sn-methylene diphosphonate in each patient. All pyrophosphate scans were strongly positive whereas the diphosphonate scan was strongly positive in only one case. We conclude that 99mT...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-197903000-00001
更新日期:1979-03-01 00:00:00
abstract::The use of gallium scanning in the treatment of patients with AIDS has been well described. In this study, 27 HIV-infected patients (Walter Reed Staging Classification I-V) with normal chest roentgenograms were evaluated to determine the occurrence of thoracic gallium abnormalities in early HIV infection. SPECT was us...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199005000-00003
更新日期:1990-05-01 00:00:00
abstract::Type A acute intramural hematoma (IMH) of the ascending aorta is defined as hemorrhage in the aortic wall in the absence of intimal disruption. Proximity to the adventitia may explain the higher incidence of rupture in IMH. We present a case of IMH, diagnosed by the presence of linear intense uptake of FDG on PET/CT, ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e318123f7a6
更新日期:2007-09-01 00:00:00
abstract:PURPOSE:The authors obtained noninvasive quantitative measurements of regional cerebral blood flow using Tc-99m L,L-ethyl cysteinate dimer (Tc-99m ECD) SPECT to evaluate cerebral collateral circulation during balloon test occlusion (BTO) of the internal carotid artery and vertebral artery (VA). METHODS:Five cases asso...
journal_title:Clinical nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1097/00003072-200209000-00005
更新日期:2002-09-01 00:00:00
abstract::Brucellosis is an endemic disease in the Middle East. Its incidence in Kuwait has increased during the last 5 years. Bone and joint involvement causes major symptoms and disabilities. Radionuclide bone scans are more sensitive than radiographs in detecting these lesions. The aim of this study is to describe the abnorm...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198802000-00008
更新日期:1988-02-01 00:00:00
abstract::Pancreatic disease can be associated with polyarthritis and panniculitis in a small number of patients, and this triad constitutes PPP syndrome. Early diagnosis is critical as it has high morbidity and mortality. Panniculitis can occur in fat present anywhere in the body. Involvement of fat in bone marrow is relativel...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000003022
更新日期:2020-06-01 00:00:00
abstract::Bone imaging using Tc-99m MDP was performed on a 68-year-old man with a newly diagnosed adenocarcinoma of the lung. The image unexpectedly showed increased activity in the heart area. Emergent echocardiography demonstrated impending pericardial tamponade. A malignant pericardial effusion was verified by pericardiocent...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198907000-00002
更新日期:1989-07-01 00:00:00
abstract::Findings on cholescintigraphy in gallbladder carcinoma are described in five patients. Four patients presenting with acute cholecystitis had nonvisualization of the gallbladder with normal hepatoenteric transit time. One of these had a large portal mass and two had liver metastasis as additional findings. The fifth pa...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198604000-00013
更新日期:1986-04-01 00:00:00
abstract::A rare case of isolated right ventricular infarction (RVI) is described. The lack of clinical and electrocardiographic findings characteristic of isolated RVI makes this pathology a diagnostic challenge. The role of the radionuclide scintigraphic procedures as a single possible tool for the diagnosis of isolated RVI i...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198412000-00009
更新日期:1984-12-01 00:00:00
abstract::Nine patients with thyroid cancer were treated with reserpine in an attempt to reduce radiation exposure to the salivary glands from 100-150 mCi doses of I-131 therapy to thyroid remnants or metastases. Three control patients were not treated with reserpine but did receive 100-150 mCi of I-131. Parotid/background rati...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198704000-00014
更新日期:1987-04-01 00:00:00
abstract:PURPOSE:This retrospective study aimed to correlate F-FDG uptake on PET/CT with isocitrate dehydrogenase enzyme isoform 1 (IDH1) mutation in patients with cerebral gliomas. Hierarchical interactions between factors affecting overall survival (OS) were also examined. METHODS:In 59 patients with glioma, the ratio of the...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000002006
更新日期:2018-05-01 00:00:00
abstract::For better delineation of regional ventilation abnormalities, a lateral-view imaging has been employed when one or more areas of abnormal retention were visible in posterior views of 133Xe washout images. It is technically simple to obtain lateral views during the 133Xe washout phase. The resulting images were found t...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-197902000-00001
更新日期:1979-02-01 00:00:00
abstract::In-111 leukocyte imaging usually yields images which are interpreted easily. Five potentially misleading cases were noted, however, of over 200 scans performed over a four-year period. These included two cases of bladder visualization without bladder inflammation and three cases of abdominal activity without intra-abd...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198606000-00004
更新日期:1986-06-01 00:00:00
abstract:PURPOSE:To determine whether rapid, dynamic SPECT imaging with Tc-99m labeled red blood cells was technically feasible and of value in the detection of cavernous hemangiomas of the liver. MATERIALS AND METHODS:The acquisition protocol for Tc-99m labeled red blood cell imaging of hepatic hemangiomas was modified with s...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199711000-00001
更新日期:1997-11-01 00:00:00
abstract::Molecular brain imaging I-FP-CIT SPECT is an important tool in evaluation of patients with parkinsonism. However, various neurodegenerative etiologies cannot be differentiated by I-FP-CIT SPECT alone. We present a case of progressive supranuclear palsy with abnormal I-FP-CIT SPECT and abnormal Tc-HMPAO SPECT depicted ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001400
更新日期:2016-12-01 00:00:00
abstract::Two castration-resistant prostate cancer patients, both with cerebral and visceral and lymphatic metastases, received multiple cycles of Lu-PSMA-617 treatments. The prognosis of both cases is dependent on brain metastases. Between Lu-PSMA-617 treatment cycles, local radiotherapy was also applied to the brain metastase...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001763
更新日期:2017-09-01 00:00:00
abstract::A 28-year-old woman with a history of prior bilateral retinoblastoma presented with general fatigue, anemia, and a urinary bladder mass seen on abdominal ultrasound and CT. She was referred for a staging 18F-FDG PET/CT, which showed an intensely FDG-avid bladder mass that was biopsied to reveal a leiomyosarcoma, with ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e3182523e33
更新日期:2013-05-01 00:00:00
abstract::Venous malformations of the parotid glands are uncommon and can be difficult to confirm on routine anatomical imaging alone because of overlap of imaging features with other more common parotid lesions. (99m)Tc RBC scans combined with SPECT/CT offer a noninvasive way to diagnose parotid venous malformations without th...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000000792
更新日期:2015-07-01 00:00:00
abstract::A 69-year-old woman presented with cognitive impairment related to attentive, executive, and mnemonic functions; progressive worsening of walking, speaking, writing, and reading ability; and double sphincter incontinence. Leukoencephalopathy, cystic lesions, and calcifications, suspected for Labrune syndrome, were obs...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000003199
更新日期:2020-10-01 00:00:00
abstract::Hemangiopericytoma is an unusual tumor that arises from vascular smooth muscle cells. It is mainly experienced in 4th to 5th decades of life and soft-tissue masses are frequently located in lower extremity, pelvis, and retroperitoneum. A 29-year-old man presented with a mass lesion in the right nasal cavity associated...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e31820ade57
更新日期:2011-06-01 00:00:00
abstract::We experienced a case of a focal pulmonary F-18 fluoro-2-deoxy-D-glucose (FDG) uptake without pulmonary computed tomography (CT) abnormality probably due to the urine FDG in the upper pole calyx of the left kidney. A 76-year-old male patient was referred for evaluation of the postoperative right lung cancer. Positron ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e3181ea32f7
更新日期:2010-09-01 00:00:00
abstract:PURPOSE:Technetium-99m pertechnetate scintigraphy is a well-established technique for diagnosing congenital hypothyroid disease. However, the biodistribution of pertechnetate (TcO4-) in neonates and young infants is not well documented. The purpose of this study was to analyze and document the biodistribution of TcO4- ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-200104000-00006
更新日期:2001-04-01 00:00:00
abstract:PURPOSE:To produce fluorodeoxyglucose (FDG) images with markers for normal organs and large blood vessels in patients with suspected lung cancer. METHODS:Dual isotope SPECT images were made using F-18 FDG- and Tc-99m-labeled autologous red cells. RESULTS:FDG-positive lesions are localized in relation to major structu...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199812000-00003
更新日期:1998-12-01 00:00:00
abstract::Early Tc-99m diphosphonate (DP) imaging was performed in 122 patients with cold thyroid nodules in an effort to differentiate benign nodules from malignant. Immediately upon completion of the routine 24-hour I-123 uptake and multiview pinhole imaging, Tc-99m DP was injected intravenously and three serial 3-minute ante...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198208000-00001
更新日期:1982-08-01 00:00:00
abstract::Edema of the lower extremities is a difficult clinical problem. It can be due to stasis, obstruction of the lymphatic channels, increased production of lymph beyond the drainage capacity of the lymphatic vessels. It is often difficult to differentiate between these varieties. Lymphoscintigraphy was performed on 164 pa...
journal_title:Clinical nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1097/00003072-199011000-00004
更新日期:1990-11-01 00:00:00
abstract::Prostate large cell neuroendocrine tumor is a rare disease. In this case, metastatic areas showing FDG uptake, somatostatin receptor positivity, and PSMA expression are shown in F-FDG PET/CT, Ga-DOTATATE PET/CT, and Ga-PSMA PET/CT in a 70-year-old man with the diagnosis of prostate large cell neuroendocrine carcinoma....
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000002322
更新日期:2019-01-01 00:00:00
abstract::Incidence of small renal masses is increasing, and preservation of healthy kidney tissue along surgical removal is a challenge, especially if the tumor is small or nonexophytic. To facilitate the location and complete excision of the tumor during surgery, we have implemented the application of the radio-guided occult ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001811
更新日期:2017-11-01 00:00:00
abstract:PURPOSE:A 68-year-old man with metastatic follicular thyroid carcinoma had T3 hyperthyroidism. MATERIAL AND METHODS:A bone scan showed intense uptake in the thyroid and multiple areas of increased uptake in the skeleton. Hyperthyroidism persisted after total thyroidectomy. Treatment with I-131 induced a transient stat...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-200502000-00001
更新日期:2005-02-01 00:00:00
abstract:AIM:The purpose of this study was to conduct a systematic review of the published literature to assess the role (indications, advantages, and limitations) of SPECT/CT for the detection of sentinel lymph node (SLN) in breast cancer. METHODS:The authors searched PubMed for published literature in English addressing this...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章,meta分析
doi:10.1097/RLU.0b013e31829af8c0
更新日期:2014-05-01 00:00:00