Imaging studies of patients with malignant fibrous histiocytoma using C-11-alpha-aminoisobutyric acid (AIB).

Abstract:

:Alpha-aminoisobutyric acid (AIB), a synthetic, nonmetabolized amino acid which is rapidly transported into viable cells by the A-type or alanine-preferring amino acid transport system, has been labeled with the short-lived, positron-emitting radionuclide carbon-11. Carbon-11 labeled AIB is currently being evaluated as a tumor imaging agent for in vivo amino acid transport studies in patients with cancer. In this study, C-11 AIB was used to image two patients with malignant fibrous histiocytoma (MFH), a pleomorphic sarcoma. Following intravenous administration of C-11 AIB, tumors in the distal femur of one patient and in the anterior chest wall of another patient were well visualized using high energy gamma scintigraphy. Since therapy may alter the accumulation of amino acids in tumor tissue, studies using C-11 AIB in patients with MFH before and after chemotherapy are in progress.

journal_name

Clin Nucl Med

authors

Schmall B,Conti PS,Bigler RE,Zanzonico PB,Reiman RE,Benua RS,Yeh SD,Dahl JR,Lee R,Laughlin JS

doi

10.1097/00003072-198701000-00005

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

22-6

issue

1

eissn

0363-9762

issn

1536-0229

journal_volume

12

pub_type

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