Abstract:
PURPOSE:A 68-year-old man with metastatic follicular thyroid carcinoma had T3 hyperthyroidism. MATERIAL AND METHODS:A bone scan showed intense uptake in the thyroid and multiple areas of increased uptake in the skeleton. Hyperthyroidism persisted after total thyroidectomy. Treatment with I-131 induced a transient state of euthyroidism lasting approximately 9 months. Further tumor growth and relapse of hyperthyroidism eventually occurred and the patient died 25 months after surgery. Molecular and cytogenetic analyses were performed. RESULTS:No mutations were detected of either of the thyrotropin receptor or of the alpha subunit of the stimulatory guanine-nucleotide-binding proteins. Hyperthyroidism was unlikely the result of thyroid-stimulating receptor antibodies. Comparative genomic hybridization analysis showed that the tumor was characterized by multiple chromosomal imbalances. CONCLUSIONS:This is an unusual case of follicular thyroid carcinoma with initial high I-131 uptake by the thyroid and bone metastases and concurrent hyperthyroidism. Despite the increased I-131 uptake in the tumor, I-131 treatment only transiently controlled the hyperthyroidism and had no effect on tumor size. The cause of hyperthyroidism remained unknown. T3 predominance was unlikely the result of type 2 deiodinase overexpression because loss of genetic material was demonstrated at chromosome 14 long arm, where type 2 deiodinase is mapped.
journal_name
Clin Nucl Medjournal_title
Clinical nuclear medicineauthors
Rosário F,Marques AR,Roque L,Rodrigues R,Ferreira TC,Limbert E,Sobrinho L,Leite Vdoi
10.1097/00003072-200502000-00001keywords:
subject
Has Abstractpub_date
2005-02-01 00:00:00pages
79-82issue
2eissn
0363-9762issn
1536-0229pii
00003072-200502000-00001journal_volume
30pub_type
杂志文章abstract::There are many causes of cerebrospinal (CSF) leaks. Most cases are secondary to blunt trauma and iatrogenic trauma caused by postoperative sequelae. Occasionally, CSF leakage may occur from nontraumatic or "spontaneous" causes, such as benign intracranial hypertension and "empty sella syndrome." Mass effect due to an ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000000292
更新日期:2014-02-01 00:00:00
abstract::A case of 65-year-old man with tuberculous splenic abscess is presented. The Ga-67 citrate scan revealed three focal areas of increased uptake in the left upper quadrant of the abdomen. The combined Tc-99m SC/Ga-67 scans revealed that these Ga-67 avid lesions localized in the splenic photon-deficit areas found in the ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199601000-00012
更新日期:1996-01-01 00:00:00
abstract::A 15-year-old boy underwent hepatobiliary scintigraphy for suspected acute cholecystitis. The initial images revealed an activity in the neighborhood of normal gallbladder fossa, suggestive of possible activity in the gallbladder, which would be inconsistent with a diagnosis of acute cholecystitis. However, after drin...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000002165
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abstract::Ga DOTATATE PET/CT in noninvasive characterization of synchronous pituitary neoplasm and meningioma in a 38-year-old man is illustrated. The patient presented with an MRI-detected lobulated enhancing sellar-suprasellar mass with erosion of bony sella measuring 4.5 × 3.5 × 3.4 cm (with differential diagnosis with germ ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001021
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abstract:PURPOSE:Dynamic PET studies with a ⁶⁸Ga-Bombesin analog, the ⁶⁸Ga-BZH₃, were performed in patients with highly suspected recurrent gliomas to investigate the effect of the receptor scintigraphy on tumor grading. Furthermore, dynamic F-18 Fluorodeoxyglucose (FDG) studies were performed for comparison. METHODS:The study...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e318203bb24
更新日期:2011-02-01 00:00:00
abstract::While performing lymphoscintigraphy to define draining lymph node groups and sentinel nodes in patients with melanoma, the authors have discovered a new lymphatic channel in two patients with tumors in the peri-umbilical area. This channel passes over the right costal margin to an interval node before passing toward t...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199503000-00013
更新日期:1995-03-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000002898
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abstract:UNLABELLED:This study evaluates the diagnostic utility of 3-phase bone scintigraphy for diagnosing osteoradionecrosis of the jaw (ORNJ). METHODS:Thirty-two consecutive patients with a history of radiation to the head and neck region (range, 62-70 Gy; mean, 68 Gy; median, 69 Gy) due to squamous cell cancer and suspecte...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000000296
更新日期:2014-01-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199905000-00006
更新日期:1999-05-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
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更新日期:1988-06-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199305000-00002
更新日期:1993-05-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198504000-00003
更新日期:1985-04-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章,评审
doi:10.1097/RLU.0b013e31823ab454
更新日期:2012-02-01 00:00:00
abstract::Unusual features of iodine-131 uptake during thyroid cancer scintigraphy may lead to a false-positive diagnosis of residual or recurrent malignancy and associated metastasis. Radiographic or cross-sectional imaging correlation should help to differentiate truly functioning thyroid lesions from physiological or artifac...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/01.rlu.0000174207.99335.19
更新日期:2005-09-01 00:00:00
abstract::Increased participation in sports by the general public has led to an increase in sports-induced injuries, including stress fractures, shin splints, arthritis, and a host of musculotendinous maladies. Bone scintigraphy with Tc-99m MDP has been used with increasing frequency in detecting stress fractures, but this stud...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198303000-00002
更新日期:1983-03-01 00:00:00
abstract::A 70-year-old man underwent Tc-methylene diphosphonate scintigraphy for staging of adenocarcinoma prostate. Scintigraphy revealed diffuse increased tracer uptake in skeletal system along with faint renal visualization, a pattern compatible with metastatic superscan. The scintigraphy also revealed increased radiotracer...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001714
更新日期:2017-08-01 00:00:00
abstract::Various etiologies could cause focal I accumulation. Hepatic cyst is one of these etiologies. Here we present a 59-year-old man with a history of papillary thyroid cancer resection who received radioiodine therapy for three times. The images after the I therapy of the second and third time showed variable activity upt...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000002442
更新日期:2019-04-01 00:00:00
abstract:PURPOSE:Fully automated synthesis of 11C-labeled 2β-carbomethoxy-3β-(4-fluorophenyl)tropane (11C CFT) as a dopamine transporter positron emission tomography (PET) tracer is performed with Sep-Pak purification, which cannot separate 11C CFT from nor-β-CFT and will result in the residual precursor nor-β-CFT in the final ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/RLU.0b013e31824c5fae
更新日期:2012-08-01 00:00:00
abstract::A case of veno-occlusive disease of the liver of unknown etiology is reported. In the case, the gross abnormality of liver parenchyma, ascites, and colloid shift to spleen, bones, and lungs found on a Tc-99m SC liver-spleen scan, and confirmed on liver biopsy, resolved completely on follow-up. Histologic correlation a...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199307000-00011
更新日期:1993-07-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/01.rlu.0000222735.19513.bb
更新日期:2006-07-01 00:00:00
abstract::Computed tomography is the standard diagnostic examination employed to identify the morbid anatomy of cerebrospinal fluid spaces in children. This noninvasive technique provides excellent anatomic information. However, CT only indirectly characterizes the cerebral spinal fluid pathways. When it is necessary to determi...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-197910000-00006
更新日期:1979-10-01 00:00:00
abstract::Usefulness of N-isopropyl-p-I-123 iodoamphetamine (I-123 IMP) for the detection of malignant melanoma and malignant lymphoma is well known. The appropriate interval from administration until image acquisition is unusual because the accumulation mechanism is different. We present a case of choroidal melanoma of the rig...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e3180a1abbd
更新日期:2007-08-01 00:00:00
abstract::We describe interesting imaging features on a FDG-PET scan in a patient with bony metastases from a rare tumor. The lesions were obscured by intense bone marrow activity after the administration of hematopoietic factor at the time of diagnosis. Correlative MRI, CT scan, and pathology findings have also been illustrate...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/01.rlu.0000218575.91735.5f
更新日期:2006-06-01 00:00:00
abstract::Metastatic calcifications according to histopathologic and scintigraphic findings have been well-defined. The authors report a postoperative case of hyperparathyroidism with multiple metastatic calcifications in the lung, kidney, stomach, heart, and vessels that were primarily detected by bone scintigraphy and demonst...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199202000-00010
更新日期:1992-02-01 00:00:00
abstract:OBJECTIVES:Talc pleurodesis can be offered to patients with hepatic hydrothorax. The authors wanted to determine their patient's eligibility for talc pleurodesis by excluding a pleural-peritoneal shunt. MATERIALS AND METHODS:The authors measured the size of the talc particles and matched them with the radionuclide par...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/01.rlu.0000134980.57598.5d
更新日期:2004-09-01 00:00:00
abstract::Hypertrophic pseudarthrosis was studied with Tc-99m MDP and Ga-67 citrate in 11 patients. Two of the 11 pseudarthroses were complicated by infection. A high concentration of both radiopharmaceuticals was obtained at all 11 sites and their distribution patterns were identical. It was therefore impossible to distinguish...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198302000-00001
更新日期:1983-02-01 00:00:00
abstract:PURPOSE:Because of paucity of data available regarding the utility of PET/CT in the diagnosis and staging of patients with olfactory neuroblastoma (ONB), we retrospectively analyzed the efficacy of PET/CT in 9 patients with ONB. MATERIALS AND METHODS:Whole-body F-18 FDG PET/CT was performed in 7 patients with newly di...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e31821a2711
更新日期:2011-10-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章,评审
doi:10.1097/00003072-200003000-00002
更新日期:2000-03-01 00:00:00
abstract::Metastatic papillary carcinoma was diagnosed in a 42-year-old woman. The cancer had invaded out of the gland and was present in many lymph nodes. After her surgical procedure, she was advised to have radioiodine. However, the patient had total renal failure and was on dialysis. Studies were carried out using a tracer ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199409000-00006
更新日期:1994-09-01 00:00:00
abstract::Hyperfunctioning thyroid adenomas causing thyrotoxicosis (Plummer's disease) is not an uncommon cause of hyperthyroidism in the elderly. Most commonly, the adenoma appears as a so-called "hot" nodule on thyroid scintigraphy causing suppression (i.e., nonvisualization) of the remainder of the gland. This report describ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199503000-00002
更新日期:1995-03-01 00:00:00