18F-FDG PET/CT in Labrune Syndrome.

Abstract:

:A 69-year-old woman presented with cognitive impairment related to attentive, executive, and mnemonic functions; progressive worsening of walking, speaking, writing, and reading ability; and double sphincter incontinence. Leukoencephalopathy, cystic lesions, and calcifications, suspected for Labrune syndrome, were observed at MRI and CT brain images. Generalized wave abnormalities were also visible at electroencephalogram. Functional brain imaging performed with F-FDG PET/CT demonstrated a decreased glucose metabolism in impaired brain regions, in accordance with MRI findings. Genetic testing confirmed a mutation of SNORD118.

journal_name

Clin Nucl Med

authors

Cuzzocrea M,Florimonte L,Scola E,Benti R,Castellani M

doi

10.1097/RLU.0000000000003199

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

e439-e440

issue

10

eissn

0363-9762

issn

1536-0229

journal_volume

45

pub_type

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