Abstract:
OBJECTIVE:To describe F-18 fluorodeoxyglucose positron emission tomography (FDG PET) profile in patients with subacute sclerosing panencephalitis (SSPE) and to investigate its possible correlation with clinical, electroencephalography (EEG) or magnetic resonance imaging/computed tomography (MRI/CT) findings. METHODS:EEG recording, MRI/CT and FDG PET imaging were performed in 16 patients with SSPE (1.9-15.6 years). FDG PET scans were assessed visually and in standardized uptake values. Finally, all the findings including clinical data were compared. RESULTS:MRI was abnormal in 10 patients. It was normal in 6 of 10 patients in earlier clinical stages. Nonspecific T2-weighted white matter findings were the most consistent MRI finding (10 patients). No thalamic lesion was detected in MRI/CT. FDG PET imaging was abnormal in 14 patients (8/10 patients in earlier stages). Glucose metabolism was decreased in thalamus, cerebellum or cerebral cortex in 12, 12, and 9 patients, respectively. Frontal cortex metabolism was preserved in earlier clinical stages. FDG PET imaging revealed putaminal hypermetabolism in 7 patients. However, MRI indicated striatal abnormality only in 2 patients with prolonged disease and later clinical stage. Three patients with putaminal hypermetabolism experienced a more rapid clinical deterioration. Onset age of SSPE, age of measles infection and EEG findings were not correlated with the imaging findings. CONCLUSIONS:Our findings suggest that FDG PET imaging can indicate affected brain regions in SSPE more confidently and earlier than MRI. FDG PET imaging would provide new insights into the pathogenesis of SSPE and help to develop new approaches to the patients with SSPE.
journal_name
Clin Nucl Medjournal_title
Clinical nuclear medicineauthors
Yilmaz K,Yilmaz M,Mete A,Celen Zdoi
10.1097/RLU.0b013e3181e9fa5fsubject
Has Abstractpub_date
2010-09-01 00:00:00pages
675-81issue
9eissn
0363-9762issn
1536-0229pii
00003072-201009000-00003journal_volume
35pub_type
临床试验,杂志文章abstract:PURPOSE:To investigate whether the evaluation of tumors, lymphoid cell-rich organs, and immune-related adverse events (IRAE) with F-FDG PET/CT can predict the efficacy and outcome of immunotherapy. METHODS:Forty patients who underwent F-FDG-PET/CT scans before and after therapy with immune checkpoint inhibitors from D...
journal_title:Clinical nuclear medicine
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journal_title:Clinical nuclear medicine
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journal_title:Clinical nuclear medicine
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journal_title:Clinical nuclear medicine
pub_type: 临床试验,杂志文章
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journal_title:Clinical nuclear medicine
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
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journal_title:Clinical nuclear medicine
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journal_title:Clinical nuclear medicine
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e3181ea32f7
更新日期:2010-09-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
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更新日期:2006-07-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
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更新日期:1992-12-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
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更新日期:2013-06-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
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journal_title:Clinical nuclear medicine
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198709000-00003
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journal_title:Clinical nuclear medicine
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journal_title:Clinical nuclear medicine
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journal_title:Clinical nuclear medicine
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journal_title:Clinical nuclear medicine
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
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更新日期:1988-12-01 00:00:00
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更新日期:2006-12-01 00:00:00
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journal_title:Clinical nuclear medicine
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
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journal_title:Clinical nuclear medicine
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更新日期:2005-09-01 00:00:00