A correlative study of FDG PET, MRI/CT, electroencephalography, and clinical features in subacute sclerosing panencephalitis.

Abstract:

OBJECTIVE:To describe F-18 fluorodeoxyglucose positron emission tomography (FDG PET) profile in patients with subacute sclerosing panencephalitis (SSPE) and to investigate its possible correlation with clinical, electroencephalography (EEG) or magnetic resonance imaging/computed tomography (MRI/CT) findings. METHODS:EEG recording, MRI/CT and FDG PET imaging were performed in 16 patients with SSPE (1.9-15.6 years). FDG PET scans were assessed visually and in standardized uptake values. Finally, all the findings including clinical data were compared. RESULTS:MRI was abnormal in 10 patients. It was normal in 6 of 10 patients in earlier clinical stages. Nonspecific T2-weighted white matter findings were the most consistent MRI finding (10 patients). No thalamic lesion was detected in MRI/CT. FDG PET imaging was abnormal in 14 patients (8/10 patients in earlier stages). Glucose metabolism was decreased in thalamus, cerebellum or cerebral cortex in 12, 12, and 9 patients, respectively. Frontal cortex metabolism was preserved in earlier clinical stages. FDG PET imaging revealed putaminal hypermetabolism in 7 patients. However, MRI indicated striatal abnormality only in 2 patients with prolonged disease and later clinical stage. Three patients with putaminal hypermetabolism experienced a more rapid clinical deterioration. Onset age of SSPE, age of measles infection and EEG findings were not correlated with the imaging findings. CONCLUSIONS:Our findings suggest that FDG PET imaging can indicate affected brain regions in SSPE more confidently and earlier than MRI. FDG PET imaging would provide new insights into the pathogenesis of SSPE and help to develop new approaches to the patients with SSPE.

journal_name

Clin Nucl Med

authors

Yilmaz K,Yilmaz M,Mete A,Celen Z

doi

10.1097/RLU.0b013e3181e9fa5f

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

675-81

issue

9

eissn

0363-9762

issn

1536-0229

pii

00003072-201009000-00003

journal_volume

35

pub_type

临床试验,杂志文章
  • Predicting Response to Immunotherapy by Evaluating Tumors, Lymphoid Cell-Rich Organs, and Immune-Related Adverse Events Using FDG-PET/CT.

    abstract:PURPOSE:To investigate whether the evaluation of tumors, lymphoid cell-rich organs, and immune-related adverse events (IRAE) with F-FDG PET/CT can predict the efficacy and outcome of immunotherapy. METHODS:Forty patients who underwent F-FDG-PET/CT scans before and after therapy with immune checkpoint inhibitors from D...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000002453

    authors: Nobashi T,Baratto L,Reddy SA,Srinivas S,Toriihara A,Hatami N,Yohannan TK,Mittra E

    更新日期:2019-04-01 00:00:00

  • Diagnostic value of bone and Ga-67 imaging in skeletal tuberculosis.

    abstract::Tuberculosis (TB) remains a major cause of skeletal infection in many parts of the world. Bone scintigraphy is an excellent screening test for bone lesions and Ga-67 scintigraphy is a useful tool for detecting inflammatory lesions. This study determined the value of bone and Ga-67 scans in patients with skeletal TB. T...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-199811000-00004

    authors: Lin WY,Wang SJ,Cheng KY,Shen YY,Changlai SP

    更新日期:1998-11-01 00:00:00

  • A pitfall in calculating differential renal function in patients with renal failure.

    abstract::Measurement of relative renal function in azotemic patients can be misleading due to elevated background activity and delayed renal concentration of radiotracer. When there is delayed excretion of the tracer and obvious splenic or hepatic activity superimposed over one of the kidneys, it often is advantageous to delay...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-199305000-00002

    authors: Sennewald K,Taylor A Jr

    更新日期:1993-05-01 00:00:00

  • Metastatic Poorly Differentiated Thyroid Cancer With Heterogeneous Distribution of 18F-FDG,68Ga-DOTATATE, and 68Ga-PSMA on PET/CT.

    abstract::We present a case of a 55-year-old man with a history of poorly differentiated metastatic thyroid cancer, which is rare and shows aggressive behavior. The patient had radioactive iodine-negative multiple metastasis on F-FDGPET/CT, therefore Ga-DOTATATE and Ga-PSMA PET/CT were performed whether an opportunity exist for...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000003362

    authors: Civan C,Isik EG,Simsek DH

    更新日期:2020-11-03 00:00:00

  • Treatment of neuroblastoma using the fused imaging guided radiotherapy (FIGURA) system.

    abstract:PURPOSE:The purpose of this study was to describe our department's experience with the fused imaging-guided radiotherapy (FIGURA) system for planning radiation treatment of high-risk neuroblastoma. PATIENTS AND METHODS:Between 1999 and 2002, 11 patients received radiation therapy as consolidation after chemotherapy in...

    journal_title:Clinical nuclear medicine

    pub_type: 临床试验,杂志文章

    doi:10.1097/01.rlu.0000214481.43868.bf

    authors: Fenig E,Mishaeli M,Yerushalmi R,Sever ZB,Ash S,Kornreich L,Yaniv I,Steinmetz A

    更新日期:2006-05-01 00:00:00

  • Deep venous thrombosis and pulmonary embolism detected by FDG PET/CT in a patient with bacteremia.

    abstract::We report incidental FDG PET/CT findings of deep venous thrombosis and pulmonary embolism in a patient with bacteremia. In this patient, diagnosis of thromboembolism was not considered until FDG PET/CT imaging was performed, and the findings prompted immediate anticoagulant therapy. The role of FDG PET/CT in venous th...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0b013e3182817aaf

    authors: Nielsen AL,Thomassen A,Hess S,Alavi A,Høilund-Carlsen PF

    更新日期:2013-04-01 00:00:00

  • 123I-FP-CIT and 99mTc-HMPAO in Pathologically Confirmed Progressive Supranuclear Palsy.

    abstract::Molecular brain imaging I-FP-CIT SPECT is an important tool in evaluation of patients with parkinsonism. However, various neurodegenerative etiologies cannot be differentiated by I-FP-CIT SPECT alone. We present a case of progressive supranuclear palsy with abnormal I-FP-CIT SPECT and abnormal Tc-HMPAO SPECT depicted ...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000001400

    authors: Matesan MC,Elojeimy S,Minoshima S

    更新日期:2016-12-01 00:00:00

  • Tc-99m HMPAO diffuse pulmonary uptake demonstrated in cigarette smokers.

    abstract::Tc-99m HMPAO, a lipophilic radiotracer used as a brain SPECT imaging agent in the diagnosis of strokes and dementias, is normally localized in the brain and the heart and is excreted through the kidneys (50%) and the hepatobiliary system (14% to 30%). There is no pulmonary localization except in the lungs of smokers. ...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-199109000-00012

    authors: Shih WJ,Gruenwald F,Biersack HJ,Berger R,Brandenburg S,Coupal J,Ryo UY

    更新日期:1991-09-01 00:00:00

  • Sacral Fatigue Fracture in a Military Recruit.

    abstract::A 19-year-old male military recruit presented with 3 weeks of persistent left hip and groin pain after abnormally twisting his hip during a hike. Initial radiographs were interpreted as negative. He subsequently underwent a bone scan which revealed linear left sacral uptake along or paralleling the sacroiliac joint. D...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000001666

    authors: Burgess MD,Johnston MJ,Silverman ED

    更新日期:2017-06-01 00:00:00

  • Evaluation of the utility of indium-111 oxine platelet imaging in renal transplant patients on cyclosporine.

    abstract::Twenty five In-111 oxine platelet imaging procedures were performed in 21 renal transplant patients to assess the value of this study for diagnosis of renal transplant rejection in recipients receiving cyclosporine (CYS) for immunosuppression. Fourteen biopsies were performed, and an extensive, in-depth review of the ...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-198612000-00007

    authors: Marcus CS,Koyle MA,Darcourt J,Vivian M

    更新日期:1986-12-01 00:00:00

  • Primary pericardial osteosarcoma on FDG PET/CT.

    abstract::We present the (18)F-FDG PET/CT images of a 38-year-old woman with primary pericardial osteosarcoma. Routine chest radiography showed an enlarged cardiac silhouette. Plain chest CT found an oval tumor with dense calcification adhered to the left back of the heart. A whole-body FDG PET/CT scan was performed to evaluate...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0b013e3182708368

    authors: Wang Q,Lin SH,Dai D,Xu WG,Li YJ

    更新日期:2013-08-01 00:00:00

  • Propionibacterium acnes Pacemaker Endocarditis in a Patient With a Redundant Loop of the Ventricular Lead: PET/CT Findings.

    abstract::A 59-year-old man with a pacemaker who was admitted for evaluation of fever was found to have a redundant loop of the ventricular lead and a vegetation attached to it. An FDG PET/CT revealed a focus of FDG uptake at the ventricular lead loop. Surgical extraction of the pacemaker device confirmed a Propionibacterium ac...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000002686

    authors: Gorospe L,Miguelena-Hycka J,Martín-García M,Ajuria-Illarramendi O,Almeida-Aróstegui NA

    更新日期:2020-01-01 00:00:00

  • A focal pulmonary F-18 FDG uptake without pulmonary CT abnormality in PET/CT probably due to mislocation of the urine F-18 FDG in the left upper renal calyx.

    abstract::We experienced a case of a focal pulmonary F-18 fluoro-2-deoxy-D-glucose (FDG) uptake without pulmonary computed tomography (CT) abnormality probably due to the urine FDG in the upper pole calyx of the left kidney. A 76-year-old male patient was referred for evaluation of the postoperative right lung cancer. Positron ...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0b013e3181ea32f7

    authors: Tani A,Kajiya Y,Nakajo M,Nakajo M

    更新日期:2010-09-01 00:00:00

  • Combined C-11 methionine and F-18 FDG PET imaging in a case of neurosarcoidosis.

    abstract:PURPOSE:PET scanning of the brain with F-18 FDG and C-11 methionine (MET) is useful for characterizing brain lesions discovered at MRI or CT. Most positive PET scans indicate malignancy. However, this case report demonstrates positive F-18 FDG and C-11 MET PET scans in a patient with a nonmalignant condition, neurosarc...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/01.rlu.0000222735.19513.bb

    authors: Ng D,Jacobs M,Mantil J

    更新日期:2006-07-01 00:00:00

  • Tc-99m HMPAO-labeled leukocytes for hematopoietic marrow imaging. Comparison with In-111 chloride.

    abstract::The current study was initiated to define whether Tc-99m leukocyte imaging, compared to In-111 chloride imaging, could provide additional information on the hematopoietic activity of the bone marrow in diffuse hematologic disorders. A total of 11 patients with hematologic disorders were studied both with Tc-99m leukoc...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-199212000-00007

    authors: Aburano T,Yokoyama K,Shuke N,Kinuya S,Takayama T,Michigishi T,Tonami N,Hisada K

    更新日期:1992-12-01 00:00:00

  • Decreased hippocampal blood flow related to memory impairment after cardiovascular surgery: assessment by reconstructed SPECT parallel to the longitudinal axis of the hippocampal formations.

    abstract::Hippocampal damage has been linked to memory impairment. To clarify the relationship between decreased hippocampal blood flow and memory impairment in patients after cardiovascular surgery, the authors compared Tc-99m HMPAO SPECT findings and Mini Mental State Examination (MMSE) scores. Eight patients who had valve re...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-199806000-00004

    authors: Nishimura T,Fukuchi K,Hayashida K,Hirose Y,Iwamoto B

    更新日期:1998-06-01 00:00:00

  • Gummatous syphilis of the adrenal gland.

    abstract::A 55-year-old man with no relevant history was analyzed for weight loss, night sweats, and left upper quadrant pain. An abdominal ultrasound and CT scan were performed, revealing a lobulated rim-enhancing mass in the left adrenal gland. Further analysis by an F-FDG PET/CT scan demonstrated high uptake in the periphery...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0b013e318262adf1

    authors: Scheurkogel MM,Tim J,Jeurissen FJ,Quarles van Ufford HM

    更新日期:2012-09-01 00:00:00

  • Serendipitous discovery of non-sestamibi-avid squamous cell lung cancer invading the heart during myocardial perfusion imaging.

    abstract::Scintigraphic and radiographic correlation of a non-sestamibi-avid lung mass invading the left ventricle serendipitously discovered during adenosine myocardial perfusion imaging is presented. The only clue to the presence of the mass was deformation of the anterior wall on SPECT myocardial perfusion imaging. This case...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0b013e31828e9921

    authors: Achong DM

    更新日期:2013-06-01 00:00:00

  • 68Ga-Prostate-Specific Membrane Antigen PET-Positive Paget Bone Disease With Metastatic Prostatic Carcinoma.

    abstract::Paget bone disease is a chronic benign bone disease characterized by excessive and abnormal bone remodeling. The scintigraphic and bone SPECT/CT hybrid imaging appearances of the affected bone(s) depend on the stage of the disease. We report the case of a patient newly diagnosed with prostate cancer who was found to h...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000003198

    authors: Engur CO,Turoglu HT,Ozguven S,Tanidir Y,Erdil TY

    更新日期:2020-09-01 00:00:00

  • 68Ga-PSMA Uptake in Middle Lobe Syndrome.

    abstract::Prostate cancer cells have abundant expression of the cell surface protein prostate-specific membrane antigen (PSMA). In recent years, PET radioligands detecting this protein has therefore gained substantial interest in prostate cancer staging. It turned out that PSMA expression can be evident in both malignant and be...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000002213

    authors: Pedersen MA,Bouchelouche K,Vendelbo MH

    更新日期:2018-10-01 00:00:00

  • SPECT gallium scanning for lymphoma and infection.

    abstract::Thirty gallium scans, using currently acceptable dosage levels (5-6 mCi) and a conventional rotating gamma camera, were performed on 20 patients with lymphoma or infection. Compared to planar scans, SPECT increased sensitivity and lesion detection from 48% to 89% in lymphoma, and from 50% to 80% in infection. The pred...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-198709000-00003

    authors: Harwood SJ,Carroll RG,Anderson M,Friedman BI,Zangara LM,Brunette AK,Kline R

    更新日期:1987-09-01 00:00:00

  • Use of Tc-99m sestamibi infusion for detection of hibernating myocardium. A preliminary report.

    abstract::To evaluate whether a prolonged infusion of Tc-99m sestamibi allows for visualization of viable myocardium in areas of hypoperfused myocardium, 25 patients were prospectively studied. Each patient was imaged four times in two consecutive days in the following manner: day 1:1) immediately after injection of Tl-201 at r...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-199505000-00014

    authors: Miron SD,Finkelhor R,Bahler R,Sodee DB,Bellon EM

    更新日期:1995-05-01 00:00:00

  • Effects of rosiglitazone on radioiodine negative and progressive differentiated thyroid carcinoma as assessed by ¹²⁴I PET/CT imaging.

    abstract:AIM:The aim of this study was to evaluate the redifferentiative and antiproliferative effects of rosiglitazone in patients with progressive differentiated thyroid cancer (DTC) without or with negligible overall radioiodine uptake. MATERIALS AND METHODS:A total of 9 patients with progressive DTC with either no or only ...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0b013e3182443ca6

    authors: Rosenbaum-Krumme SJ,Freudenberg LS,Jentzen W,Bockisch A,Nagarajah J

    更新日期:2012-03-01 00:00:00

  • Early Detection of Bone Metastasis in Small Cell Neuroendocrine Carcinoma of the Cervix by 68Ga-DOTATATE PET/CT Imaging.

    abstract::The neuroendocrine small cell carcinoma of the cervix is a rare malignancy that has a poor prognosis due to early lymphatic and hematogenous spread. We herein report a case of a 27- year-old woman who was referred for initial staging of a neuroendocrine small cell carcinoma with previous unremarkable structural imagin...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000001498

    authors: Damian A,Lago G,Rossi S,Alonso O,Engler H

    更新日期:2017-03-01 00:00:00

  • Synchronous pure epithelioid angiomyolipoma of the kidney and retroperitoneal schwannoma in the same patient on 18F-FDG PET/CT imaging.

    abstract::A 21-year-old woman was admitted to our hospital after incidental detection of a left renal lesion on ultrasound scan. Abdominal contrast-enhanced CT scan revealed a moderately enhanced lesion in the left kidney and a round mass with slight enhancement in the retroperitoneum. FDG PET/CT imaging was performed for whole...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0b013e31825b2218

    authors: Dong A,Wang Y,Zuo C

    更新日期:2013-02-01 00:00:00

  • Thoracic gallium uptake in patients with lymphomatoid granulomatosis.

    abstract::Lymphomatoid granulomatosis (LG) is a rare condition with histological similarities to Wegener's granulomatosis and malignant lymphoma. Characteristically there is an angiocentric, angiodestructive lymphoreticular cell infiltrate. The lungs are usually affected, and, less frequently, the skin, nervous system, kidney, ...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-198812000-00009

    authors: Tien R,Moore WH,Glasser LM,Dhekne RD,Long SE

    更新日期:1988-12-01 00:00:00

  • Bilateral Paget disease of the calcaneus diagnosed by conventional bone scintigraphy.

    abstract::An 85-year-old woman who had an invasive ductal carcinoma of the breast and elevated alkaline phosphatases (420 U/L) was referred for Tc-99m MDP bone scintigraphy for initial evaluation of skeletal metastases. Bone symptoms were limited to chronic pain in both knees. A bone scan revealed pagetoid findings in both calc...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/01.rlu.0000247783.43949.c1

    authors: Duch J,Fuster D,Ortín J,Setoain X,Pons F

    更新日期:2006-12-01 00:00:00

  • Hepatobiliary scintigraphy in an immunosuppressed patient with hepatocellular dysfunction and acute cholecystitis: diagnostic dilemmas posed by delayed gallbladder visualization.

    abstract::A case of acute cholecystitis in an immunosuppressed patient with hepatocellular dysfunction is reported. The diagnostic dilemmas posed by the lack of specific sonographic findings, the possibility of acute gallbladder disease without early cystic duct obstruction, and the absence of clear guidelines for the interpret...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-199809000-00006

    authors: Assi Z,Bohnen NI,Shapiro B

    更新日期:1998-09-01 00:00:00

  • Delayed ischemia due to cerebral vasospasm occult to transcranial Doppler. An important role for cerebral perfusion SPECT.

    abstract::Cerebral vasospasm after subarachnoid hemorrhage is very common, but it is not universally detectable by transcranial Doppler. SPECT imaging of regional cerebral blood flow with Tc-99m exametazime serves as a complementary test to transcranial Doppler in the evaluation of patients at high risk for vasospasm. The signi...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-199704000-00006

    authors: Lewis DH,Newell DW,Winn HR

    更新日期:1997-04-01 00:00:00

  • Epiphrenic diverticulum: potential pitfall in thyroid cancer iodine-131 scintigraphy.

    abstract::Unusual features of iodine-131 uptake during thyroid cancer scintigraphy may lead to a false-positive diagnosis of residual or recurrent malignancy and associated metastasis. Radiographic or cross-sectional imaging correlation should help to differentiate truly functioning thyroid lesions from physiological or artifac...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/01.rlu.0000174207.99335.19

    authors: Nguyen BD,Roarke MC

    更新日期:2005-09-01 00:00:00