Abstract:
PURPOSE:This study was performed to evaluate the diagnostic accuracy of brain perfusion SPECT in patients visiting the cognitive disorder clinic for initial evaluation using 3D-SSP compared with using standard transaxial section. MATERIALS AND METHODS:Standard transaxial section displays and 3D-SSP z-score maps obtained after administration of Tc-99m ECD or I-123 IMP were randomly interpreted in 315 patients who visited initially to the cognitive disorder clinic (age 46-88 years; 162 women, 153 men). Sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy were calculated and receiver operating characteristic (ROC) analysis was performed. RESULTS:One hundred thirty-seven patients were clinically diagnosed with Alzheimer disease and 178 patients were diagnosed with other disorders and age-associated cognitive decline. Sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy calculated using standard transaxial display were 61%, 70%, 61%, 70%, and 66%, respectively, and using the 3D-SSP z-score map were 90%, 74%, 73%, 90%, and 81%, respectively. Particularly, the sensitivity value improved in mild cases compared with severe cases using 3D-SSP. Diagnostic performance with 3D-SSP was superior in both mild dementia (Az = 0.64 [section] vs 0.81 [3D-SSP], P = 0.001) and severe dementia (Az = 0.75 [section] vs 0.90 [3D-SSP], P = 0.002). CONCLUSIONS:Brain perfusion SPECT was useful for diagnosis in patients who come to the cognitive disorder clinic for initial evaluation using 3D-SSP.
journal_name
Clin Nucl Medjournal_title
Clinical nuclear medicineauthors
Uchida Y,Minoshima S,Okada S,Kawata T,Ito Hdoi
10.1097/01.rlu.0000246818.24566.54subject
Has Abstractpub_date
2006-12-01 00:00:00pages
764-73issue
12eissn
0363-9762issn
1536-0229pii
00003072-200612000-00006journal_volume
31pub_type
杂志文章,随机对照试验abstract:PURPOSE:To produce fluorodeoxyglucose (FDG) images with markers for normal organs and large blood vessels in patients with suspected lung cancer. METHODS:Dual isotope SPECT images were made using F-18 FDG- and Tc-99m-labeled autologous red cells. RESULTS:FDG-positive lesions are localized in relation to major structu...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199812000-00003
更新日期:1998-12-01 00:00:00
abstract::Imaging of Y internal pair production with conventional photomultiplier detector PET technology has been previously reported for patients with malignant/metastatic liver lesions treated with Y radioembolization (RE). We present a 54-year-old man with unresectable liver metastases from rectal carcinoma (involving the r...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001385
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abstract::Intravascular large B-cell lymphoma is a rare type of non-Hodgkin lymphoma characterized by intravascular proliferation of clonal lymphocytes within the lumen of small vessels, which is often fatal. Diffuse FDG uptake in the lung without clear/evident CT findings, "hot lung," is quasi-pathognomonic for lung intravascu...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000002939
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abstract::Type A acute intramural hematoma (IMH) of the ascending aorta is defined as hemorrhage in the aortic wall in the absence of intimal disruption. Proximity to the adventitia may explain the higher incidence of rupture in IMH. We present a case of IMH, diagnosed by the presence of linear intense uptake of FDG on PET/CT, ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e318123f7a6
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abstract:ABSTRACT:A 62-year-old woman had progressively developing throbbing right neck pain for 1 year. The pain radiated to the right suboccipital area, sometimes accompanied by breathlessness. To rule out cancer, patient received FDG PET/CT, which showed an intraspinal cord intense FDG-avid calcified mass at the level of the...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000003477
更新日期:2021-03-01 00:00:00
abstract::The method for determining blood volume has evolved substantially since first attempts were made in the latter part of the nineteenth century with the exsanguination of animals. The now accepted methods are based on indicator dilution methodologies. First attempts utilized inert dyes such as Evans Blue and Cardiogreen...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章,评审
doi:10.1097/RLU.0b013e318292f370
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND AND AIMS:We aimed to assess the characteristics of glucose utilization in left and right ventricle (LV, RV) myocardium with F-18 fluorodeoxyglucose (FDG) on positron emission tomography in patients with pulmonary arterial hypertension (PAH), and to evaluate whether predominance of RV glucose metabolism as co...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
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abstract::A case of false-negative Tc-99m MDP bone scintigrams, taken at one and two weeks for pathologic fractures in a patient with metabolic bone disease and a super-scan appearance, is described. The patient had renal osteodystrophy, and postparathyroidectomy hypocalcemia. Postoperative seizures caused multiple pathologic f...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198707000-00004
更新日期:1987-07-01 00:00:00
abstract:PURPOSE:Computed tomography (CT) remains the gold standard for delineation of tumor volumes for radiotherapy (RT) planning. However, positron emission tomography (PET) overlay on CT has shown to impact the gross target volume (GTV), decrease intraobserver variability, and change the treatment planning in a significant ...
journal_title:Clinical nuclear medicine
pub_type: 临床试验,杂志文章
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更新日期:2010-04-01 00:00:00
abstract::The images of a patient with acromegaly, who previously underwent operation for pituitary adenoma, were obtained. The MRI scan showed a mass in the right cavernous sinus, with biochemical test results positive for the presence of a hormonally active adenoma. The patient was scheduled for CyberKnife radiotherapy. Radio...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000000535
更新日期:2014-12-01 00:00:00
abstract::Ga-67 urinary excretion was examined in 59 patients. The 72-hour urinary excretion rate ranged from 4.3 to 67.8% of the injected dose. Within the first 24 hours, 60.9% of the 72-hour urinary excretion was excreted. There was no significant difference in the Ga-67 urinary excretion rate between males and females, nor b...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199004000-00012
更新日期:1990-04-01 00:00:00
abstract::Squamous cell carcinoma is the most common malignant neoplasm of the oral cavity, and it contributes approximately 90% of all oral malignancies. We present a case of a squamous cell carcinoma of the tongue with rare site of bilateral adrenal metastases on F-FDG PET/CT with response evaluation after chemotherapy. ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001521
更新日期:2017-02-01 00:00:00
abstract::The goal of bleeding scintigraphy is to localize the site of origin of a hemorrhage to within general regions of the large or small bowel. Activity is typically seen to extravasate from the blood pool into the lumen, and the collection of activity then moves on sequential images, as a result of the cathartic action of...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-200201000-00006
更新日期:2002-01-01 00:00:00
abstract::Parameters of systolic and diastolic function obtained from radionuclide ventriculography (RNV) were evaluated in nine cardiac allograft recipients. In 25 examinations, left end-diastolic volume (LEDV), cardiac output (CO), left ejection fraction (LEF), right ejection fraction (REF), heart rate (HR), peak filling rate...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198903000-00007
更新日期:1989-03-01 00:00:00
abstract::A 24-year-old female gymnast had a 3-month history of bilateral forearm pain. A Tc-99m MDP bone scan demonstrated focally increased activity in the radial shafts on blood pool and delayed images, characteristic of fatigue fractures. Fatigue fractures commonly occur in the lower extremities. Upper extremity fatigue fra...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199408000-00002
更新日期:1994-08-01 00:00:00
abstract::Patients with prune belly syndrome usually have tortuous ureters, which can cause difficulty in the interpretation of renal scan used to evaluate possible urine leak after renal transplant. We reported a renal scan finding in a pediatric renal transplant patient with prune belly syndrome. The radioactivity in the dila...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001031
更新日期:2016-03-01 00:00:00
abstract::A 69-year-old man with newly diagnosed prostate cancer PSA 274 ng/mL, Gleason 4+3, T-stage 3b) underwent Ga-PSMA PET/CT for staging with follow-up scans 6 and 13 weeks after androgen deprivation therapy (ADT) initiation. Six weeks after ADT initiation, lymph node metastases observed at staging showed metabolic and rad...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000002273
更新日期:2018-11-01 00:00:00
abstract::An 83-year-old asymptomatic woman with a history of breast cancer treated with resection, radiation, and chemotherapy was studied with F-18 FDG positron emission tomography/computed tomography (PET/CT) for staging purposes. The whole-body F-18 FDG PET/CT images revealed poorly circumscribed, bilateral soft tissue mass...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/01.rlu.0000178786.99368.1d
更新日期:2005-10-01 00:00:00
abstract::We present plain x-ray examination, bone scintigraphy, computed tomography, and magnetic resonance imaging of 2 patients diagnosed with prostate cancer who complained of hip pain. Bone scintigraphy was suggestive for metastases. Further radiologic investigation revealed benign etiologies for the hip pain; calcific ten...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e3180a1acc3
更新日期:2007-08-01 00:00:00
abstract::A 57-year-old man with a history of metastatic melanoma and sclerotic bone lesions seen on CT was referred for F NaF PET/CT evaluation of active skeletal metastases. While the bone lesions had no uptake and were therefore thought to represent sequela of previously treated disease, an unexpected area of F NaF uptake wa...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000000371
更新日期:2014-10-01 00:00:00
abstract::SPECT imaging with I-123 IMP or Tc-99m HMPAO was performed in two patients with Creutzfeldt-Jakob disease to evaluate abnormalities in brain perfusion. In the first patient, there was decreased perfusion of the left frontal, parietal, and temporal lobes. CT and MRI were negative. In the second patient, there was patch...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199603000-00010
更新日期:1996-03-01 00:00:00
abstract::Four cases of ankylosing spondylitis are presented in which radionuclide bone studies indicated focal abnormalities of the spine. In three patients, the area of abnormal nuclide uptake corresponded to a site of pseudarthrosis, and in the fourth an acute fracture was present. As such focal lesions on bone scans are unu...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198105000-00007
更新日期:1981-05-01 00:00:00
abstract::During a Tc-99m DTPA study, activity simultaneously appeared in the kidneys and in a right lateral band. This was due to an inflammatory tract and not to urinary drainage. ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198601000-00020
更新日期:1986-01-01 00:00:00
abstract:PURPOSE:To establish camera-based methods for estimating Tc-99m mercaptoacetyltriglycine (MAG3) clearance without blood sampling. MATERIALS AND METHODS:The results of renal scintigraphy with Tc-99m MAG3 obtained from 160 patients were analyzed retrospectively. Eight renogram parameters were calculated for each patient...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e31821a2a96
更新日期:2011-11-01 00:00:00
abstract::A 57-year-old woman with type 2 diabetes was admitted to our hospital presenting with generalized bone pains, hypercalcemia, and elevated parathyroid hormone level. Enhanced CT scan demonstrated a large soft tissue mass in the right anterior mediastinum. Tc-MIBI scintigraphy revealed the focal accumulation of radiotra...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e31825ae8b6
更新日期:2012-09-01 00:00:00
abstract::Gallium-67 citrate imaging for the staging of lymphomas was performed in three patients receiving Corynebacterium parvum (C. parvum) immunotherapy. Unexpected uptake at the site of C. parvum injections was identified and although the mechanism of localization is not determined by this study, similarities between C. pa...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-197809000-00009
更新日期:1978-09-01 00:00:00
abstract:PURPOSE:To compare the accuracy of three camera-assisted methods for the measurement of Tc-99m mercaptoacetyltriglycine (MAG3) clearance. MATERIALS AND METHODS:MAG3 renal scintigraphy was performed in 21 adults with different degrees of renal function. Posterior views were obtained that included the heart and the kidn...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-200109000-00001
更新日期:2001-09-01 00:00:00
abstract::The use of prednisolone is one major risk factor for osteonecrosis in patients with systemic lupus erythematosus. Bone scintigraphy can be a diagnostic tool for early diagnosis. We present a case who had collar osteophytes at the bilateral femoral heads, which mimicked osteonecrosis in the planar bone scintigram. An S...
journal_title:Clinical nuclear medicine
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更新日期:2017-03-01 00:00:00
abstract::A 54-year-old woman was referred for imaging studies after presentation for palpitations and a palpable thyroid nodule. The patient underwent a dual-phase single-agent Tc-99m sestamibi scan followed later by a thyroid ultrasound at an outside hospital. The Tc-99m sestamibi scan showed a marked focus of activity separa...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/01.rlu.0000167481.79767.93
更新日期:2005-07-01 00:00:00
abstract::Intense FDG uptake by bone marrow following recent chemotherapy limits evaluation for osseous metastases. The impact of marrow rebound on accuracy of (18)F-fluoride PET/CT is unclear. A 73-year-old woman with breast cancer presented for restaging FDG PET/CT, which showed intense activity throughout almost the entire a...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e3182996138
更新日期:2013-09-01 00:00:00