Estimation of Tc-99m MAG3 clearance using camera-based methods without blood sampling.

Abstract:

PURPOSE:To establish camera-based methods for estimating Tc-99m mercaptoacetyltriglycine (MAG3) clearance without blood sampling. MATERIALS AND METHODS:The results of renal scintigraphy with Tc-99m MAG3 obtained from 160 patients were analyzed retrospectively. Eight renogram parameters were calculated for each patient based on the area under the renogram (area method) and slope of the renogram (slope method) using different periods for analysis (1-2 and 1-2.5 minutes for the area method; 0.5-1.5 and 0.5-2 minutes for the slope method) and different backgrounds for subtraction (perirenal and subrenal backgrounds). The 8 parameters were then correlated with MAG3 clearance measured by the single-sample methods proposed by Russell et al and Bubeck et al to determine the equation for the conversion of renogram parameters to clearance. RESULTS:All 8 renogram parameters were highly correlated with clearance measured by the single-sample methods, and the obtained equations enabled the estimation of clearance from image data. Selection between the area and slope methods, between different periods for analysis, or between perirenal and subrenal backgrounds did not cause large differences in the estimation. CONCLUSION:The camera-based methods determined in the present study allow the estimation of MAG3 clearance with acceptable accuracy.

journal_name

Clin Nucl Med

authors

Inoue Y,Ohtomo K

doi

10.1097/RLU.0b013e31821a2a96

subject

Has Abstract

pub_date

2011-11-01 00:00:00

pages

1012-6

issue

11

eissn

0363-9762

issn

1536-0229

pii

00003072-201111000-00009

journal_volume

36

pub_type

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