Abstract:
PURPOSE:Primary hyperparathyroidism is a disease of uncertain etiology that results from hypersecretion of parathyroid hormone (PTH) by the parathyroid gland. In most institutions, the preferred imaging protocol utilizes a dual-phase technique with Tc-99m sestamibi which is reported to be more sensitive than earlier protocols involving TI-201 with Tc-99m pertechnetate subtraction. The purpose of this study is to evaluate the accuracy and clinical utility of Tc-99m sestamibi dual-phase scintigraphy for localizing hyperfunctioning parathyroid tissue. MATERIALS AND METHODS:We retrospectively reviewed thirty-nine consecutive hyperparathyroid patients who received a dual-phase Tc-99m sestamibi parathyroid scan. Thirty-seven of the subjects subsequently underwent a bilateral neck exploration and parathyroidectomy. Each scan interpretation was then correlated with the histopathologic diagnosis and the patients' post-surgical clinical course. RESULTS:The sestamibi dual-phase imaging protocol correctly localized 21 of 25 parathyroid adenomas and identified 8 out of 10 cases of hyperplasia. Our overall sensitivity and specificity were 83% and 75%, respectively. In addition, four of the adenomas were successfully localized intraoperatively using a gamma probe. CONCLUSION:Parathyroid imaging with sestamibi appears to be superior to TI-201/Tc-99m pertechnetate subtraction based on the reported results of both techniques at various institutions. Dual-phase sestamibi imaging appears to be useful and cost-effective for presurgical localization of hyperfunctioning parathyroid tissue. In addition, sestamibi imaging in conjunction with an intraoperative probe is a very promising technique that has the potential to provide both localization information of a suspected parathyroid adenoma and to facilitate its surgical removal by reducing operation time.
journal_name
Clin Nucl Medjournal_title
Clinical nuclear medicineauthors
Klieger P,O'Mara Rdoi
10.1097/00003072-199804000-00003subject
Has Abstractpub_date
1998-04-01 00:00:00pages
208-11issue
4eissn
0363-9762issn
1536-0229journal_volume
23pub_type
杂志文章abstract::Tc-99m pertechnetate radionuclide scrotal scanning was performed on nine hospitalized boys with anaphylactoid purpura and acute scrotal tenderness. Scrotal involvement in anaphylactoid purpura is generally a part of the basic pathological process (i.e., vasculitis). Sometimes testicular torsion could not be excluded b...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199304000-00006
更新日期:1993-04-01 00:00:00
abstract::Renal neuroendocrine tumor (NET) is an extremely rarely occurring disease. The sporadic reports in the literature are mostly case reports, or less commonly small studies. In cases of metastatic disease from renal NET, there are no established therapies. We are reporting our experience with a patient with extensive oss...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001386
更新日期:2016-12-01 00:00:00
abstract::A patient with an asymptomatic nonsecreting left adrenal pheochromocytoma concentrated I-123 MIBG. Iodine-123 MIBG scintigraphy showed abnormal uptake in the left adrenal bed. The authors conclude that I-123 MIBG imaging may allow the in vivo diagnosis of non-functioning pheochromocytomas when there is no clinical evi...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199501000-00005
更新日期:1995-01-01 00:00:00
abstract::Mental nerve neuropathy (numb chin/lip syndrome) is a sensory neuropathy presenting with numbness in the distribution of the inferior alveolar nerve/mental nerve (chin and lower lip). This is typically unilateral and can be secondary to dental disease or malignancy. When caused by malignancy, these symptoms can be eit...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e3182868ae5
更新日期:2013-05-01 00:00:00
abstract:AIM:In this study, we investigated the relationship of cerebral tau deposition (F-tau-AD-ML 104 PET/CT) with glucose metabolism (F-FDG PET/CT) and cognitive function in patients with Alzheimer disease (AD). PATIENTS AND METHODS:Seventy subjects (Mini Mental State Examination [MMSE] score <18 = 37 [AD]; MMSE score, 18-...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000002791
更新日期:2019-11-01 00:00:00
abstract::A 30-year-old man had severe left anterior knee pain after a trivial injury. A three-phase bone scan diagnosed this condition to be reflex sympathetic dystrophy, which was subsequently confirmed by sympathetic blockade. ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199512000-00004
更新日期:1995-12-01 00:00:00
abstract::Extrapulmonary small cell carcinoma (SCC) is an uncommon malignancy. A 57-year-old man was referred because of a 1-month history of left lumbago. MR images showed an ovoid tumor in the left adrenal gland. FDG PET/CT showed intense FDG uptake of the left adrenal tumor with thrombosis of the left renal vein. The patient...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e318286bfcc
更新日期:2013-11-01 00:00:00
abstract::An unusual case is described in which in spite of clinical, scintigraphic and histologic findings strongly supportive of a diagnosis of "hyperacute rejection," recovery of renal function occurred. These findings are in contrast to the current literature in which it is generally accepted that a renal allograft showing ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198302000-00005
更新日期:1983-02-01 00:00:00
abstract::Scintigraphy was instrumental in two histologically proven cases of forme fruste melorheostosis. Radionuclide bone scans demonstrated a moderately increased uptake of radiopharmaceutical localized to the "flowing" cortical hyperostosis of melorheostosis observed radiographically. The medullary portion of the affected ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199406000-00009
更新日期:1994-06-01 00:00:00
abstract::Burkitt lymphoma (BL) is a poorly differentiated non-Hodgkin B-cell lymphoma, more frequent in children than in adults. The extranodal debut of the disease is rare. We report a 43-year-old male patient with history of dyspnea. Burkitt lymphoma diagnosis was reached after biopsy of a pleural lesion. An initial staging ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000000885
更新日期:2015-09-01 00:00:00
abstract::A 21-year-old woman was admitted to our hospital after incidental detection of a left renal lesion on ultrasound scan. Abdominal contrast-enhanced CT scan revealed a moderately enhanced lesion in the left kidney and a round mass with slight enhancement in the retroperitoneum. FDG PET/CT imaging was performed for whole...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e31825b2218
更新日期:2013-02-01 00:00:00
abstract::The value of using heparin as a pharmacologic intervention to induce a positive scintiscan was studied in a patient with chronic occult gastrointestinal bleeding. When all standard diagnostic tests (upper and lower gastrointestinal series, upper and lower endoscopy, and conventional noninterventional Tc-99m RBC imagin...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198404000-00003
更新日期:1984-04-01 00:00:00
abstract::A 54-year-old man with mesenteric carcinoid tumor metastatic to the liver completed staging Ga-DOTATATE PET/CT demonstrating uptake in multiple hepatic lesions consistent with liver metastases with additional asymmetric increased uptake in the right greater than the left breast. Subsequent bilateral diagnostic mammogr...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000002597
更新日期:2019-10-01 00:00:00
abstract::The incidence of unilobar or bilobar pathology is disproportionately high in patients with duplication of the gallbladder. The results of ultrasound and Tc-99m DISIDA studies in one case of gallbladder duplication are presented. An awareness of gallbladder anomalies may improve the accuracy of hepatobiliary imaging by...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198610000-00004
更新日期:1986-10-01 00:00:00
abstract::Optimal scan time of F-fluorocholine (FCH) PET/CT for localization of hyperfunctioning parathyroid glands is poorly documented. We report a small series of 9 histologically proven hyperfunctioning parathyroid gland with heterogeneous temporal uptake profile. Thirty-minute dynamic acquisition starting just after F-fluo...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000002132
更新日期:2018-07-01 00:00:00
abstract::A 52-year-old woman with right breast cancer was referred for 18F-fluoride whole-body PET/CT for the assessment of bone metastases. The peripheral i.v. access was not obtained after multiple attempts. The radiopharmaceutical was administered by oral route. ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000000250
更新日期:2013-12-01 00:00:00
abstract::Idiopathic fibrosis and malignant lymphoma were studied with positron emission tomography (PET) using 2-deoxy-2-[F-18]fluoro-D-glucose (F-18DG). Cases of retroperitoneal fibrosis and sclerosing peritonitis showed low F-18DG uptake with the mass/muscle radioactivity (M/M) ratio 2.0 and 1.9, respectively. A case of para...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199205000-00002
更新日期:1992-05-01 00:00:00
abstract::Radioimmunoscintigraphy (RIS) with Tc-99m labeled 170H.82, an intact murine monoclonal antibody (MAb) was performed in 27 patients with suspected primary, recurrent, or metastatic breast cancer. For radioimmunoimaging the authors used a double-headed, high-resolution gamma camera. The lesions detected by RIS were eval...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199701000-00007
更新日期:1997-01-01 00:00:00
abstract:PURPOSE:The purpose of this study was to describe our department's experience with the fused imaging-guided radiotherapy (FIGURA) system for planning radiation treatment of high-risk neuroblastoma. PATIENTS AND METHODS:Between 1999 and 2002, 11 patients received radiation therapy as consolidation after chemotherapy in...
journal_title:Clinical nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1097/01.rlu.0000214481.43868.bf
更新日期:2006-05-01 00:00:00
abstract::A 67-year-old woman underwent F-FDG PET/CT after developing a fever of unknown origin. PET/CT revealed intensive FDG uptake at the nasal and lung lesions. On the laboratory data, serum myeloperoxidase antineutrophil cytoplasmic antibodies (ANCA) titer was elevated, although serum directed against proteinase 3 (PR3) AN...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e3182817a95
更新日期:2014-01-01 00:00:00
abstract::Ocular metastases secondary to thyroid cancer are extremely uncommon, typically affecting the orbit rather than the globe and uvea. Within the uveal structures, the choroid is more commonly involved than the iris and ciliary body. We present a 56-year-old male patient who underwent total thyroidectomy for metastatic p...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e31827a2275
更新日期:2013-02-01 00:00:00
abstract::We reported a 24-year-old woman who developed a movement disorder of mouth and limbs during systemic lupus erythematosus. Brain MRI did not find any abnormalities. Increased FDG uptake in basal ganglia was found using FDG PET/CT brain scan. The symptoms remitted after therapy and the activities of the original hyperme...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001450
更新日期:2017-01-01 00:00:00
abstract::The case history of a patient with Budd-Chiari syndrome (BCS) is described. The underlaying disease proved to be essential thrombocytosis. Congential elliptocytosis was also present. The value of the conventional liver scan, percutaneous splenoportoscintigraphy and isotopic phlebography of the inferior vena cava in th...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-197810000-00005
更新日期:1978-10-01 00:00:00
abstract::Early Tc-99m diphosphonate (DP) imaging was performed in 122 patients with cold thyroid nodules in an effort to differentiate benign nodules from malignant. Immediately upon completion of the routine 24-hour I-123 uptake and multiview pinhole imaging, Tc-99m DP was injected intravenously and three serial 3-minute ante...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198208000-00001
更新日期:1982-08-01 00:00:00
abstract::The cerebral hemodynamics and oxygen metabolism before and after the recanalization of the occluded sinus were evaluated using O-15 positron emission tomography (PET) scanning in a 21-year-old woman with superior sagittal sinus thrombosis. During the initial presentation, there was increased regional cerebral blood vo...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/01.rlu.0000162603.26986.ac
更新日期:2005-06-01 00:00:00
abstract::A 73-year-old man diagnosed with Merkel cell carcinoma of the left nasal ala was referred for preoperative scintigraphic sentinel lymph node mapping. In three separate foci around the lesion, 0.2 mCi of Tc-sulfur colloid was intradermally administered. Planar images demonstrated accumulation of tracer midway between t...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001351
更新日期:2016-11-01 00:00:00
abstract::One hundred patients with suspected acute abdominal inflammation were imaged at 0.5, 2-3, 4-6, and 24 hours after the administration of Tc-99m HMPAO labeled autologous leukocytes. Scan findings were retrospectively compared with final diagnosis, serum C-reactive protein (CRP), and antibiotic treatment. Clinical findin...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199009000-00001
更新日期:1990-09-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to compare 99mTc-MDP bone scanning, 18F NaF PET/CT, 18F FDG PET/CT, and whole-body MRI (WBMRI) for detection of known osseous metastases. PATIENTS AND METHODS:This prospective pilot trial (September 2007-April 2009) enrolled 10 participants (5 men, 5 women, 47-81 years old) diagnose...
journal_title:Clinical nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1097/RLU.0b013e3182815f64
更新日期:2013-07-01 00:00:00
abstract::A 50-year-old man with recently diagnosed prostate cancer was referred for Ga-prostate-specific membrane antigen (PSMA) PET/CT with elevated prostate-specific antigen. PET/CT demonstrated increased PSMA uptake in an undisplaced transverse fracture of the L1 vertebral body. This case illustrates that PSMA uptake can oc...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001599
更新日期:2017-06-01 00:00:00
abstract::Thoracic pain is an entity that can be difficult to diagnose etiologically. Once the cardiac origin has been ruled out, the rheumatologic, neoplastic, and infectious causes have to be taken into account. We present the case of a patient with atypical chest pain after triple-bypass surgery in whom F-FDG PET/CT scan sho...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000002237
更新日期:2018-10-01 00:00:00