18F-FDG PET/CT findings preceded elevation of serum proteinase 3 antineutrophil cytoplasmic antibodies in Wegener granulomatosis.

Abstract:

:A 67-year-old woman underwent F-FDG PET/CT after developing a fever of unknown origin. PET/CT revealed intensive FDG uptake at the nasal and lung lesions. On the laboratory data, serum myeloperoxidase antineutrophil cytoplasmic antibodies (ANCA) titer was elevated, although serum directed against proteinase 3 (PR3) ANCA titer was within normal limits. One month after treatment, follow-up PET/CT revealed decreased FDG uptake at the lesions. One year later, serum PR3-ANCA titer elevated, which finally led to a diagnosis of Wegener granulomatosis (WG). WG lesions may be detected earlier by FDG PET/CT than by serum PR3-ANCA titers.

journal_name

Clin Nucl Med

authors

Ito K,Minamimoto R,Yamashita H,Morooka M,Okasaki M,Mimori A,Kubota K

doi

10.1097/RLU.0b013e3182817a95

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

e67-8

issue

1

eissn

0363-9762

issn

1536-0229

journal_volume

39

pub_type

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