Tc-99m labeled leukocytes in imaging of patients with suspected acute abdominal inflammation.

Abstract:

:One hundred patients with suspected acute abdominal inflammation were imaged at 0.5, 2-3, 4-6, and 24 hours after the administration of Tc-99m HMPAO labeled autologous leukocytes. Scan findings were retrospectively compared with final diagnosis, serum C-reactive protein (CRP), and antibiotic treatment. Clinical findings were confirmed with surgery, barium enema, or sigmoidoscopy in 61 patients, and diagnosis was based only on clinical findings in 13 patients. In 26 patients, symptoms subsided before a final diagnosis was made. Tc-99m leukocyte images were positive in 45 of the 61 patients with a confirmed diagnosis, including all patients with acute cholecystitis (N = 4) and inflammatory bowel disease (N = 8). They were also positive in nineteen out of 25 patients who had acute colonic diverticulitis and in 6 out of 7 who had intra-abdominal abscesses. Abnormal activity was found in patients with colonic carcinoma, small bowel infarction, and acute appendicitis. Abnormal activity was visualized in 0.5-hour images in all but one of the positive cases. With the exception of two postoperative cases, malignant lymphoma, and a liver abscess, a CRP level of greater than 75 mg/L was associated with positive image findings. Antibiotic treatment did not affect imaging findings. Imaging with Tc-99m labeled leukocytes appears to be valuable for detecting and localizing abdominal inflammation, and three-phase imaging during the first 4-6 hours is recommended. In some cases, 24-hour images may be useful for distinguishing small bowel from large bowel inflammation.

journal_name

Clin Nucl Med

authors

Laitinen R,Tähtinen J,Lantto T,Vorne M

doi

10.1097/00003072-199009000-00001

subject

Has Abstract

pub_date

1990-09-01 00:00:00

pages

597-602

issue

9

eissn

0363-9762

issn

1536-0229

journal_volume

15

pub_type

杂志文章
  • (67)Ga SPECT/CT accurately localized recurrent hepatic cyst infection in patients with autosomal dominant polycystic kidney disease.

    abstract::Hepatic pyocyst is a rare but potentially life-threatening complication of autosomal dominant polycystic kidney disease. With extensive hepatic cystic disease, localization of a pyocyst and targeted aspiration or drainage is often a diagnostic challenge. Two patients with autosomal dominant polycystic kidney disease a...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000000402

    authors: Ayesa SL,Gradinscak DJ,Schembri GP

    更新日期:2014-07-01 00:00:00

  • Neonatal hypothyroid disease: absent salivary gland evident on technetium-99m pertechnetate scan.

    abstract:PURPOSE:Technetium-99m pertechnetate scintigraphy is a well-established technique for diagnosing congenital hypothyroid disease. However, the biodistribution of pertechnetate (TcO4-) in neonates and young infants is not well documented. The purpose of this study was to analyze and document the biodistribution of TcO4- ...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-200104000-00006

    authors: Kiratli PO,Gordon I,Nagaraj N

    更新日期:2001-04-01 00:00:00

  • Malignant pleural effusion and Tc-99m MDP accumulation.

    abstract::Two case reports of malignant pleural effusion from breast carcinoma, with scans showing a striking accumulation of Tc-99m MDP, are presented. The Tc-99m MDP was in the pleural fluid and not in the pleura as demonstrated by shift with gravity. Possible mechanisms of malignant effusion accumulation of Tc-99m MDP are su...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-198207000-00009

    authors: Lamki L,Cohen P,Driedger A

    更新日期:1982-07-01 00:00:00

  • Tc-99m HMPAO to demonstrate diffuse cortical necrosis in vivo.

    abstract::Tc-99m hexamethylpropylene amineoxime (HMPAO) is a novel radiopharmaceutical demonstrated to be a sensitive indicator of abnormalities of cerebral perfusion. Most reports in the literature have evaluated patients with gross perfusion deficits, such as cerebrovascular accidents, and with dementia, where patterns of dif...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-199103000-00007

    authors: McEwan AJ,Jackson FI,Catz Z,Schmidt RP,Hooper HR,Mattjews JJ

    更新日期:1991-03-01 00:00:00

  • 201Tl Myocardial Perfusion Imaging in a Case of Double-Inlet Left Ventricle: Correlate Anatomic Information of SPECT With MRI.

    abstract::Double-inlet left ventricle (DILV) is a congenital heart disease that only a single left ventricle and a rudimentary right ventricle are developed. Because of lack of anatomic landmark, interpretation of Tl myocardial perfusion imaging in DILV is essentially challenging for unusual anomaly. We report the case of a 44-...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000001961

    authors: Chang MC,Lee ML,Yang PT

    更新日期:2018-03-01 00:00:00

  • Autonomous functioning thyroid nodules and 131I in diagnosis and therapy after 50 years of experience: what is still open to debate?

    abstract:PURPOSE OF THE REPORT:Autonomous functioning thyroid nodules (AFTN), defined as "hot nodules" at thyroid scan, are often cured by radioiodine treatment. The aim of our study was to investigate the long-term outcome in patients treated with an 131I calculated dose, to identify a possible "size-tailored" dose, and to sim...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0b013e318286bbda

    authors: Ronga G,Filesi M,D'Apollo R,Toteda M,Di Nicola AD,Colandrea M,Travascio L,Vestri AR,Montesano T

    更新日期:2013-05-01 00:00:00

  • 18F-FDOPA PET Imaging in Prolactinoma.

    abstract::Pituitary macroadenoma constitutes a frequently misdiagnosed benign tumor. We report herein a case where such macroadenoma, a prolactinoma, was incidentally discovered in a 63-year-old man who had been referred to F-FDG PET and F-FDOPA PET imaging for a pharmacoresistant epilepsy. An increased uptake was documented fo...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000001721

    authors: Ginet M,Cuny T,Schmitt E,Marie PY,Verger A

    更新日期:2017-08-01 00:00:00

  • Variable 131I Activity in Multiple Hepatic Cysts in a Patient With Thyroid Cancer.

    abstract::Various etiologies could cause focal I accumulation. Hepatic cyst is one of these etiologies. Here we present a 59-year-old man with a history of papillary thyroid cancer resection who received radioiodine therapy for three times. The images after the I therapy of the second and third time showed variable activity upt...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000002442

    authors: Shao F,Tang J,Lan X

    更新日期:2019-04-01 00:00:00

  • Ureteral Metastasis From Prostate Cancer: A PSMA PET Pitfall.

    abstract::A 72-year-old man with a history of prostate adenocarcinoma initially managed by radical prostatectomy and salvage radiation therapy underwent resection of a left vas deferens recurrence identified on PSMA PET. Despite an initial response, PSA failed to fall below 3.5 ng/L, prompting re-evaluation with PSMA PET/CT: a ...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000003136

    authors: Chaussé G,Skinnider B,Crook J,Black P,Abikhzer G,Probst S

    更新日期:2020-09-01 00:00:00

  • Metastatic Poorly Differentiated Thyroid Cancer With Heterogeneous Distribution of 18F-FDG,68Ga-DOTATATE, and 68Ga-PSMA on PET/CT.

    abstract::We present a case of a 55-year-old man with a history of poorly differentiated metastatic thyroid cancer, which is rare and shows aggressive behavior. The patient had radioactive iodine-negative multiple metastasis on F-FDGPET/CT, therefore Ga-DOTATATE and Ga-PSMA PET/CT were performed whether an opportunity exist for...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000003362

    authors: Civan C,Isik EG,Simsek DH

    更新日期:2020-11-03 00:00:00

  • Automated volume determination of the liver and spleen from Tc-99m colloid SPECT imaging. Quantification of the liver functional and nonfunctional tissue in disease.

    abstract::An automated volume determination program using SPECT imaging with Tc-99m has been validated by both phantom and patient studies. Its use for monitoring change of function of the liver and change in tumor mass during different therapy regimes has been assessed. The technique is not restricted to the estimation of the ...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-199007000-00009

    authors: Kavanagh GJ,Kavanagh JT,Kavanagh PB,Irwin LE,Perkins AC,Swanson LA

    更新日期:1990-07-01 00:00:00

  • Tc-99m MIBI scintigraphy in tall cell variant of papillary thyroid carcinoma with negative radioiodine scan.

    abstract::We report on a 45-year-old man who had a mass on the wall of the anterior right hemithorax. An excisional biopsy indicated carcinoma metastasis from thyroid malignancy. Tc-99m methoxyisobutyl isonitrile (MIBI) scintigraphy revealed markedly increased activity on the left side of the thyroid and the thoracic wall mass....

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0b013e3181813035

    authors: Kaya M,Cermik TF

    更新日期:2008-09-01 00:00:00

  • Remnants of normal tissue in polycystic disease of the liver. A cause for difficulty in the interpretation of indium-111 white blood cell study.

    abstract::On In-111 WBC images, diffuse homogeneous uptake of the radiopharmaceutical should be present throughout the liver. The authors present a case of a febrile patient with polycystic liver disease in whom the normal diffuse uptake was not seen. Instead, the images demonstrated focal areas of uptake, which suggested infec...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-199311000-00009

    authors: Even-Sapir E,Barnes DC,Iles SE

    更新日期:1993-11-01 00:00:00

  • PET/CT in a Patient Diagnosed With Dandy-Walker Syndrome.

    abstract::The Dandy-Walker syndrome (DWS) is a rare congenital posterior fossa malformation characterized by aplasia or hypoplasia of the cerebellar vermis, cystic dilatation of the fourth ventricle, and enlargement of the posterior fossa. We present a 52-year-old Caucasian man diagnosed with gastrointestinal stromal tumor and ...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000000871

    authors: Infante JR,Garcia L,Rayo JI,Serrano J,Dominguez ML,Moreno M

    更新日期:2016-01-01 00:00:00

  • Role of 18F-choline PET/CT in biochemically relapsed prostate cancer after radical prostatectomy: correlation with trigger PSA, PSA velocity, PSA doubling time, and metastatic distribution.

    abstract:PURPOSE:The aim of this study was to evaluate the efficacy of ¹⁸F-choline PET/CT (18FCH-PET/CT) in restaging patients previously treated by radical prostatectomy for a prostate cancer, presenting with biochemical relapse during follow-up (FU). PATIENTS AND METHODS:Three hundred thirty-one patients referred to us from ...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0b013e318266cc38

    authors: Marzola MC,Chondrogiannis S,Ferretti A,Grassetto G,Rampin L,Massaro A,Castellucci P,Picchio M,Al-Nahhas A,Colletti PM,Marcolongo A,Rubello D

    更新日期:2013-01-01 00:00:00

  • Misleading findings on indium-111 leukocyte images.

    abstract::In-111 leukocyte imaging usually yields images which are interpreted easily. Five potentially misleading cases were noted, however, of over 200 scans performed over a four-year period. These included two cases of bladder visualization without bladder inflammation and three cases of abdominal activity without intra-abd...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-198606000-00004

    authors: Goodgold HM,Samuels LD

    更新日期:1986-06-01 00:00:00

  • Is there an optimal scan time for 6-[F-18]fluoro-L-DOPA PET in pheochromocytomas and paragangliomas?

    abstract:PURPOSE:To define the appropriate scan time for fluorine-18-labeled dihydroxyphenylalanine (F-18 DOPA) PET in oncological imaging of pheochromocytomas and paragangliomas. MATERIALS AND METHODS:F-18 DOPA PET examinations were performed in 9 patients with 7 pheochromocytomas and 4 head and neck paragangliomas using a de...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0b013e318238f550

    authors: Hentschel M,Rottenburger C,Boedeker CC,Neumann HP,Brink I

    更新日期:2012-02-01 00:00:00

  • Septic Haemophilus influenzae polyarthritis demonstrated best with Tc-99m HMPAO labeled leukocytes.

    abstract::A 5-year-old girl with fever and tenderness in her left wrist and right ankle was hospitalized. Bone scanning and Tc-99m labeled leukocyte imaging showed increased uptake in these joints and also in her left knee. These radionuclide methods helped determine the diagnosis and were superior to plain radiography and CT s...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-199012000-00007

    authors: Vorne M,Salo S,Anttolainen I,Peltola H,Mokka R

    更新日期:1990-12-01 00:00:00

  • Radioaerosol Imaging Predicts the Utility of Aerosolized Antifungal Therapy in Allergic Bronchopulmonary Aspergillosis.

    abstract::A 10-year-old girl with a history of complicated cystic fibrosis was hospitalized for pulmonary exacerbation with allergic bronchopulmonary aspergillosis and severe right upper lobe bronchiectasis diagnosed with chest radiograph and CT. She was started on itraconazole during the hospitalization in attempt to decrease ...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000002264

    authors: Rodriguez K,Siegel A

    更新日期:2018-11-01 00:00:00

  • Superior Vena Cava Syndrome Induced Collateral Circulation on 99mTc-Macroaggregated Albumin Lung Perfusion Scintigraphy.

    abstract::Perfusion lung scintigraphy using SPECT/CT is one mainstay in diagnosing pulmonary embolism. Although typically almost all tracer will be accumulated in the lung capillaries, occasionally abnormal uptake can be detected. As superior vena cava syndrome leads to aberrant blood flow, tracer injected to an arm vein might ...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000003127

    authors: Kersting D,Guberina N,Umutlu L,Stuschke M,Hautzel H

    更新日期:2020-10-01 00:00:00

  • Tl-201 chloride SPECT imaging of hepatocellular carcinoma.

    abstract:PURPOSE:Tl-201 chloride has been used to image viable tumors in various sites of the body. There has been limited use of Tl-201 below the diaphragm because of normal uptake in the liver, spleen, kidneys, and intestines. The use of sequential Tl-201 and Tc-99m sulfur colloid in the detection and characterization of susp...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-199612000-00007

    authors: Kempf JS,Hudak R,Abdel-Dayem HM,Freiman H,Cheung Y

    更新日期:1996-12-01 00:00:00

  • Practical hepatobiliary imaging using pretreatment with sincalide in 139 hepatobiliary studies.

    abstract::Hepatobiliary studies were performed over a three-year period on 139 patients suspected of having cystic duct obstruction. Each patient was infused intravenously with sincalide, a C-terminal octapeptide of CCK, 15 minutes prior to the administration of the hepatobiliary imaging agent Tc-99m paraisopropyl iminodiacetic...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-198505000-00003

    authors: Patterson FK,Kam JW

    更新日期:1985-05-01 00:00:00

  • Usefulness of cephalad views in thallium-201 myocardial imaging.

    abstract::In addition to imaging in the conventional positions, TI-201 myocardial imaging was also performed in a 25 degree cephalad projection. This resulted in improved imaging, especially of the inferior wall. Myocardial images are presented in five patients in whom areas of absent activity were most sharply delineated in th...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-198105000-00009

    authors: Esquerre JP,Yeboles L,Guiraud R

    更新日期:1981-05-01 00:00:00

  • 18F-FDG PET as a monitoring tool to assess treatment response in bilateral adrenal histoplasmosis.

    abstract::A 60-year-old woman with clinical and biochemical features suggestive of adrenal insufficiency was found to have bilateral adrenal masses on CT scan and was subjected to F-FDG PET scan. The scan showed hypermetabolic mediastinal nodes in addition to intense tracer uptake in bilateral adrenal masses. CT-guided adrenal ...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000000400

    authors: Kasaliwal R,Malhotra G,Bukan A,Asopa RV,Wanjare S,Shah NS

    更新日期:2014-06-01 00:00:00

  • COVID-19: Incidental Diagnosis by 18F-FDG PET/CT.

    abstract::A 73-year-old man with chronic obstructive pulmonary disease and no known malignancies was evaluated for back pain. MR examination showed lumbar spine compression fractures, and an F-FDG PET/CT scan was requested to assess for skeletal metastatic disease and potential detection of a primary neoplasm. The PET/CT examin...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000003154

    authors: Sinha P,Sinha S,Schlehr E,Schlehr JM

    更新日期:2020-08-01 00:00:00

  • Metastatic Medulloblastoma: 18F-FDG and 68Ga-DOTANOC PET/CT in Response Evaluation.

    abstract::We describe the utility of molecular imaging with F-FDG and Ga-DOTANOC PET for treatment response assessment in a case of metastatic medulloblastoma. F-FDG and Ga-DOTANOC PET/CT revealed extensive metastases to bone and bone marrow. Patient subsequently had an excellent response to systemic chemotherapy which was evid...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000003435

    authors: ArunRaj ST,Kumar A,Kp H,Mohan N,Gupta S,Tripathi M,Bal C

    更新日期:2020-12-07 00:00:00

  • The utilization of technetium-99m CPI as a myocardial perfusion imaging agent in exercise studies.

    abstract::Myocardial perfusion imaging with Tc-99m carbomethoxyisopropylisonitrile (CPI) was compared with Tl-201 imaging in 22 patients who were assessed for coronary artery disease. There was agreement between Tc-99m CPI and Tl-201 imaging for detecting segmental myocardial ischemia and fixed defects in 185/198 (93%) of left ...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-198709000-00001

    authors: Sia ST,Holman BL,Campbell S,Lister-James J,English RJ,Kronauge JF,Davison A,Jones AG

    更新日期:1987-09-01 00:00:00

  • Solitary Acute Inflammatory Demyelinating Lesion of the Cervical Spinal Cord Mimicking Malignancy on FDG PET/CT.

    abstract::A 43-year-old woman presented with numbness of the left hand and leg for 4 weeks. MRI of the spinal cord revealed an intramedullary lesion with central nodular enhancement at the C3 level. Primary tumor or metastasis of the cervical spinal cord was suspected. FDG PET/CT showed focal hypermetabolism of the spinal cord ...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000003287

    authors: Liu Q,Liu M,Bai Y,Dong A

    更新日期:2020-12-01 00:00:00

  • Innocent intramural gastric uptake of gallium-67 in a case of AIDS.

    abstract::In a patient with AIDS, marked uptake of Ga-67 in the stomach walls initially was regarded with a high degree of suspicion for gastric involvement. Results of subsequent intragastric tests, including biopsy and culture, proved negative. Caution should be exercised when considering further costly and/or invasive proced...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-198602000-00015

    authors: McNeill JA,Llaurado JG

    更新日期:1986-02-01 00:00:00

  • Clinical application of captopril renal scintigraphy in Takayasu's arteritis.

    abstract::Takayasu's disease (pulseless disease) is an uncommon chronic inflammatory disease primarily affecting the medium and large arteries, with a strong predilection for the aortic arch and its branches; hence, it sometimes is referred to as aortic arch syndrome. The etiology is unknown, although a systemic immunologic pro...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-199309000-00002

    authors: Balingit AG,Anderson JH

    更新日期:1993-09-01 00:00:00