Tc-99m HMPAO to demonstrate diffuse cortical necrosis in vivo.

Abstract:

:Tc-99m hexamethylpropylene amineoxime (HMPAO) is a novel radiopharmaceutical demonstrated to be a sensitive indicator of abnormalities of cerebral perfusion. Most reports in the literature have evaluated patients with gross perfusion deficits, such as cerebrovascular accidents, and with dementia, where patterns of diffuse perfusion deficit were reported comparable with those seen in PET studies. We report a patient in whom there was the rapid onset of dementia, with the HMPAO images demonstrating diffuse loss of cortical perfusion in a nonfocal, and nonsegmental, fashion. Correlation with postmortem examination demonstrates good concordance between the diffuse nature of HMPAO loss, and diffuse cortical necrosis throughout both cerebral hemispheres. The technique was shown to be more sensitive than transmission CT scanning in demonstrating the extent of the deficit, and it correlated closely with the functional deficits noted in the patient.

journal_name

Clin Nucl Med

authors

McEwan AJ,Jackson FI,Catz Z,Schmidt RP,Hooper HR,Mattjews JJ

doi

10.1097/00003072-199103000-00007

subject

Has Abstract

pub_date

1991-03-01 00:00:00

pages

167-9

issue

3

eissn

0363-9762

issn

1536-0229

journal_volume

16

pub_type

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