Correlation between iodine-131 MIBG imaging and biological markers in advanced neuroblastoma.

Abstract:

:I-131 metaiodobenzylguanidine (MIBG) imaging was performed in 38 patients with advanced neuroblastoma. Abnormal images were found in patients with elevations of urinary vanillylmandelic acid and dopamine and high serum neuron-specific enolase levels. Normal or minimal elevation of markers was seen in patients with negative images. In follow-up studies after chemotherapy, the disappearance of abnormal uptake was noted in those patients with normal marker values. A persistently abnormal uptake occurred in patients with high marker values. Conversion from a normal image to an abnormal image also occurred in patients whose markers became elevated. I-131 MIBG imaging is sensitive in detecting active foci of a neuroblastoma and is useful in monitoring chemotherapy in these patients.

journal_name

Clin Nucl Med

authors

Yeh SD,Helson L,Benua RS

doi

10.1097/00003072-198801000-00014

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

46-52

issue

1

eissn

0363-9762

issn

1536-0229

journal_volume

13

pub_type

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