FDG PET/CT evaluation of treatment response in patients with recurrent colorectal cancer.

Abstract:

AIM:to evaluate the treatment response in patients with recurrent colorectal cancer (CRC) using FDG PET/CT. MATERIALS AND METHODS:a total of 32 recurrent CRC patients (21 males, 11 females; mean age, 52.8 years) were included in this retrospective study. All patients underwent a baseline and follow-up FDG PET/CT scans after chemotherapy. Of 32 patients, 23 patients had follow-up carcinoembryonic antigen (CEA) levels. RESULTS:on qualitative analysis of baseline and follow-up FDG PET/CT studies, there were 20 nonresponders and 12 were responders. On quantitative analysis, there were 19 nonresponders and 13 were responders. In responders, baseline and follow-up mean SUV(max) were 11.8 ± 10.1 and 3.7 ± 4.1, respectively (significant decrease, P = 0.001). Among nonresponders, baseline and follow-up mean SUV(max) were 8.1 ± 5.2 and 14.1 ± 9.0, respectively (significant increase, P = 0.003). There was no association between response and different factors like age, sex, diagnosis, extent of the lesions, and number of lesions. CONCLUSION:FDG PET/CT appears to be useful modality in evaluating chemotherapy response and can differentiate responders from nonresponders in recurrent CRC patients.

journal_name

Clin Nucl Med

authors

Shamim SA,Kumar R,Shandal V,Halanaik D,Kumar G,Bal CS,Malhotra A

doi

10.1097/RLU.0b013e3181feeb48

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

11-6

issue

1

eissn

0363-9762

issn

1536-0229

pii

00003072-201101000-00003

journal_volume

36

pub_type

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