Doxorubicin-induced cardiac toxicity and cardiac rest gated blood pool imaging.

Abstract:

:Anthracyclines are one of the most commonly used and potent chemotherapeutic agents. Doxorubicin (Adriamycin) is one common anthracycline used to treat many solid tumors including breast, sarcomas, gynecologic and hematological malignancies, such as leukemias and lymphomas. However, its use is often limited due to dose-dependent cardiotoxicity. As a result, patients receiving doxorubicin should have close monitoring of their left ventricular function. The gated cardiac blood pool (GBP) study is one of the most accurate and reproducible methods of assessing left ventricular function. This report presents an overview of (1) the incidence, clinical course, mechanisms, pathology, prevention, and monitoring of doxorubicin-induced cardiotoxicity (DIC), (2) the use of GBP studies in monitoring for DIC, and (3) 2 algorithms for the use of GBP studies in monitoring for DIC. This report concludes with a proposed algorithm for the use of GBP studies in DIC. With an understanding of DIC, GBP studies, and various algorithms, the interpreting physician may help the oncologist identify DIC earlier, more accurately, and before it becomes clinically apparent.

journal_name

Clin Nucl Med

authors

Aiken MJ,Suhag V,Garcia CA,Acio E,Moreau S,Priebat DA,Chennupati SP,Van Nostrand D

doi

10.1097/RLU.0b013e3181b7d76f

subject

Has Abstract

pub_date

2009-11-01 00:00:00

pages

762-7

issue

11

eissn

0363-9762

issn

1536-0229

pii

00003072-200911000-00005

journal_volume

34

pub_type

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