Abstract:
PURPOSE OF THE REPORT:Autonomous functioning thyroid nodules (AFTN), defined as "hot nodules" at thyroid scan, are often cured by radioiodine treatment. The aim of our study was to investigate the long-term outcome in patients treated with an 131I calculated dose, to identify a possible "size-tailored" dose, and to simplify follow-up procedures. PATIENTS AND METHODS:Retrospective analysis was carried out on 1402 cases, covering a period of 50 years, of AFTN treated with an 131I calculated dose. Our study focused on nodular size and mean administered dose. Concordance between thyroid scan and serum TSH levels at 3-6 months from treatment was considered. RESULTS:A single 131I dose was effective for the vast majority of patients (93%). The outcome was influenced by nodular size. On the basis of the Italian dose limit for outpatient treatment, our population was divided into subgroups according to administered doses (more or less than 16 mCi) and nodular dimensions: no differences in outcome were observed for each class of nodule size. A dose ≤10 mCi was effective on the smaller nodules (50.1% of our population). The agreement between TSH and scan after treatment was 90.3% at 3 months and 94.5% at 6 months. CONCLUSIONS:131I therapy with a calculated dose is an effective treatment of AFTN. If a fixed dose is chosen, 16 mCi is often resolutive and for nodules <3 cm a dose of 10 mCi can suffice. Nodules >5 cm are eligible for surgery. TSH is the only parameter required to evaluate the outcome.
journal_name
Clin Nucl Medjournal_title
Clinical nuclear medicineauthors
Ronga G,Filesi M,D'Apollo R,Toteda M,Di Nicola AD,Colandrea M,Travascio L,Vestri AR,Montesano Tdoi
10.1097/RLU.0b013e318286bbdasubject
Has Abstractpub_date
2013-05-01 00:00:00pages
349-53issue
5eissn
0363-9762issn
1536-0229journal_volume
38pub_type
杂志文章abstract::Intense FDG uptake by bone marrow following recent chemotherapy limits evaluation for osseous metastases. The impact of marrow rebound on accuracy of (18)F-fluoride PET/CT is unclear. A 73-year-old woman with breast cancer presented for restaging FDG PET/CT, which showed intense activity throughout almost the entire a...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e3182996138
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journal_title:Clinical nuclear medicine
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doi:10.1097/RLU.0b013e31828e98dc
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journal_title:Clinical nuclear medicine
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journal_title:Clinical nuclear medicine
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doi:10.1097/00003072-198403000-00002
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journal_title:Clinical nuclear medicine
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journal_title:Clinical nuclear medicine
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journal_title:Clinical nuclear medicine
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000003002
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/01.rlu.0000127088.20310.d0
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journal_title:Clinical nuclear medicine
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e31827a230f
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to compare 99mTc-MDP bone scanning, 18F NaF PET/CT, 18F FDG PET/CT, and whole-body MRI (WBMRI) for detection of known osseous metastases. PATIENTS AND METHODS:This prospective pilot trial (September 2007-April 2009) enrolled 10 participants (5 men, 5 women, 47-81 years old) diagnose...
journal_title:Clinical nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1097/RLU.0b013e3182815f64
更新日期:2013-07-01 00:00:00
abstract::PET/CT with Ga-labeled prostate-specific membrane antigen (PSMA) is increasingly recognized as the best imaging modality for disease staging and detection of recurrent prostate cancer. Despite its name, PSMA expression has been reported in a number of nonprostatic benign and malignant pathologies. Apparently, angioneo...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000002103
更新日期:2018-07-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001400
更新日期:2016-12-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000000640
更新日期:2015-03-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e3182708574
更新日期:2013-01-01 00:00:00
abstract::A 79-year-old man with prostate cancer underwent Ga prostate-specific membrane antigen (Ga-PSMA) dual-time-point PET/CT scan to evaluate tumor activity due to early satiety, unquantified weight loss, and elevation of prostate-specific antigen (PSA), demonstrating thickening of the gastric wall with intense tracer upta...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000002030
更新日期:2018-05-01 00:00:00
abstract::The case history of a patient with Budd-Chiari syndrome (BCS) is described. The underlaying disease proved to be essential thrombocytosis. Congential elliptocytosis was also present. The value of the conventional liver scan, percutaneous splenoportoscintigraphy and isotopic phlebography of the inferior vena cava in th...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-197810000-00005
更新日期:1978-10-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001320
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e3182641d01
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journal_title:Clinical nuclear medicine
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
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更新日期:2016-06-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199804000-00003
更新日期:1998-04-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000000853
更新日期:2015-08-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198905000-00006
更新日期:1989-05-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001457
更新日期:2017-03-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199403000-00009
更新日期:1994-03-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
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更新日期:2019-05-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198408000-00003
更新日期:1984-08-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
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更新日期:2016-10-01 00:00:00