Somatostatin imaging of neuroendocrine-differentiated prostate cancer.

Abstract:

:After prolonged androgen deprivation therapy, a subset of castrate-resistant prostate cancer patients will develop neuroendocrine prostate cancer (NEPC) associated with resistance to further hormonal therapy and frequent visceral metastases. Imaging the presence of somatostatin receptors on the cancer cell surface may provide a readily available, noninvasive means to distinguish adenocarcinoma from NEPC. This distinction is important for therapeutic decision making and may open the door for developing novel radionuclide targets for the treatment of this aggressive subtype of prostate cancer. We describe a case of NEPC successfully imaged using In-labeled octreotide.

journal_name

Clin Nucl Med

authors

Hope TA,Aggarwal R,Simko JP,VanBrocklin HF,Ryan CJ

doi

10.1097/RLU.0000000000000776

subject

Has Abstract

pub_date

2015-06-01 00:00:00

pages

540-1

issue

6

eissn

0363-9762

issn

1536-0229

journal_volume

40

pub_type

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